&lt;i&gt;Salvia miltiorrhiza&lt;/i&gt; Prevents Methylglyoxal-Induced Glucotoxicity &lt;i&gt;via&lt;/i&gt; the Regulation of Apoptosis-Related Pathways and the Glyoxalase System in Human Umbilical Vein Endothelial Cells

Kim, Jae Sung; Lee, Jae Hyuk; Hong, Seong Min; Cho, Kyohee; Kim, Sun Yeou

doi:10.1248/bpb.b21-00507

Cited by 4 publications

(3 citation statements)

References 31 publications

(55 reference statements)

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“…Similar to SM (Dan Shen), ligustrazine (Chuan Xiong Qin) has protective effects on ischemia/reperfusion (I/R) in rats [22]. The mechanisms of SM (Dan Shen) treatment against CVDs can be simply generalized by inhibiting the cardiac cell apoptosis to reduce myocardial damage [23]. Though the exact mechanisms of the beneficial effects of SM (Dan Shen) and ligustrazine (Chuan Xiong Qin) on CVDs are not fully understood, the combined use of ligustrazine (Chuan Xiong Qin) with SM (Dan Shen) shows very promising potential in the treatment of heart injury in rats.…”

Section: Ligustrazine (Chuan Xiong Qin) With Salvia Miltiorrhiza (Dan...mentioning

confidence: 99%

The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Dong¹,

Huang²,

Pu³

2023

IJDDP

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Review The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases Peihua Dong , Yu Huang , and Yujie Pu ,* Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China * Correspondence: yujiepu@cityu.edu.hk Received: 29 December 2022 Accepted: 18 January 2023 Published: 10 February 2023 Abstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.

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Section: Ligustrazine (Chuan Xiong Qin) With Salvia Miltiorrhiza (Dan...mentioning

confidence: 99%

The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Dong¹,

Huang²,

Pu³

2023

IJDDP

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“…HUVEC migration was also performed using transwell chambers with an 8.0 µmsized porous membrane. HUVECs cultured in 6-well plates were allowed to grow to 90% confluence and exposed to MGO (100 µM) or vehicle control for 24 h. In some experiments, the cells were pretreated with AG (100 µM) for 1 h before MGO treatment [35,36]. The cells were then detached and 2 × 10 4 cells were added to the upper chambers, followed by stimulation with Ang-1 (200 ng/mL).…”

Section: Cell Migration Assaymentioning

confidence: 99%

Glycation of Tie-2 Inhibits Angiopoietin-1 Signaling Activation and Angiopoietin-1-Induced Angiogenesis

Zhou

Chen

et al. 2022

IJMS

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The impairment of the angiopoietin-1 (Ang-1)/Tie-2 signaling pathway has been thought to play a critical role in diabetic complications. However, the underlying mechanisms remain unclear. The present study aims to investigate the effects of Tie-2 glycation on Ang-1 signaling activation and Ang-1-induced angiogenesis. We identified that Tie-2 was modified by advanced glycation end products (AGEs) in aortae derived from high fat diet (HFD)-fed mice and in methylglyoxal (MGO)-treated human umbilical vein endothelial cells (HUVECs). MGO-induced Tie-2 glycation significantly inhibited Ang-1-evoked Tie-2 and Akt phosphorylation and Ang-1-regulated endothelial cell migration and tube formation, whereas the blockade of AGE formation by aminoguanidine remarkably rescued Ang-1 signaling activation and Ang-1-induced angiogenesis in vitro. Furthermore, MGO treatment markedly increased AGE cross-linking of Tie-2 in cultured aortae ex vivo and MGO-induced Tie-2 glycation also significantly decreased Ang-1-induced vessel outgrow from aortic rings. Collectively, these data suggest that Tie-2 may be modified by AGEs in diabetes mellitus and that Tie-2 glycation inhibits Ang-1 signaling activation and Ang-1-induced angiogenesis. This may provide a novel mechanism for Ang-1/Tie-2 signal dysfunction and angiogenesis failure in diabetic ischaemic diseases.

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“…Bioinformatics and network-based analysis have demonstrated that RA could act on several target genes involved in inflammatory responses, anti-oxidant balance, tumor initiation, and progression to form a systemic pharmacological network (Guan et al 2021 ). RA has been extensively studied for its therapeutic roles and nutraceutical properties to improve human and animal health based on its remarkable pharmacological and medicinal characteristics (Choi et al 2016 ; Değer and Çavuş 2020 ; Kim et al 2021b ). In recent years, the design and development of potential nutraceutical and efficacious medicinal products from natural sources have attracted considerable interest (Alam et al 2021 , 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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<i>Salvia miltiorrhiza</i> Prevents Methylglyoxal-Induced Glucotoxicity <i>via</i> the Regulation of Apoptosis-Related Pathways and the Glyoxalase System in Human Umbilical Vein Endothelial Cells

Cited by 4 publications

References 31 publications

The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Glycation of Tie-2 Inhibits Angiopoietin-1 Signaling Activation and Angiopoietin-1-Induced Angiogenesis

Biomedical features and therapeutic potential of rosmarinic acid

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