&lt;i&gt;KISS1&lt;/i&gt; Gene Expression in the Developing Brain of Female Pigs in Pre- and Peripubertal Periods

Ieda, Nahoko; Uenoyama, Yoshihisa; Tajima, Yoko; Nakata, T.; Kano, Masatoshi; Naniwa, Yousuke; Watanabe, Yousuke; Minabe, Shiori; Tomikawa, Junko; Inoue, N.; Matsuda, Fuko; Ohkura, Satoshi; Maeda, Kei‐ichiro; Tsukamura, Hiroko

doi:10.1262/jrd.2013-129

Cited by 22 publications

(17 citation statements)

References 27 publications

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“…The expression of kisspeptin in the ARC was correlated to the age-related increase in LH pulses, suggesting that kisspeptin neurons in this region of the hypothalamus are critical for the pubertal transition in gonadotropin secretion of sheep. This contrasts with the gilt in which the expression of the kisspeptin gene in the PeV region of the hypothalamus was undetectable, by in situ hybridization, during pubertal maturation (from 0 to 5 months of age) (Ieda et al, 2014). Robust expression of the kisspeptin gene in the ARC of these gilts was observed, but the ARC expression of kisspeptin did not differ with age or puberty status.…”

Section: Oestrogen Feedback and Expression Of Kisspeptincontrasting

confidence: 71%

“…During sexual maturation in the ewe, messenger RNA (mRNA) for kisspeptin is expressed in the discrete region of the periventricular (PeV) nucleus (Redmond et al, 2011a). Similarly, kisspeptin gene expression is found in the PeV of sexually mature and developing gilts (Tomikawa et al, 2010;Ieda et al, 2014). This is a similar area as the AVPV in mice and may be important for GnRH secretion controlling ovulation in pigs.…”

Section: Structural Organization Of Kisspeptin Neurons In the Hypothamentioning

confidence: 99%

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Review: kisspeptin and reproduction in the pig

Lents

2019

Animal

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The activation of the hypothalamic–pituitary axis is critical for the initiation and maintenance of reproductive cycles in pigs and is influenced by a number of factors, such as nutrition, metabolism and gonadal steroids. Kisspeptin is a neuropeptide that is expressed in discrete regions of the porcine hypothalamus and is positioned to mediate the action of many of these factors. The expression of kisspeptin in the pig hypothalamus does not appear to be regulated by gonadal steroids in the same way as other species. It is unclear if kisspeptin is mediating nutritional or metabolic effects on gonadotropin secretion in pigs as it takes large deficits in feed intake or BW to affect hypothalamic expression of the KISS1 gene in the porcine hypothalamus. There appears to be little genetic diversity in kisspeptin or its receptor that is useful for improving reproduction in swine. Both peripheral and central injection of kisspeptin strongly stimulates the secretion of gonadotropin hormones, LH and FSH, in gilts. Similarly, synthetic analogues have been developed and showed potential promise as tools to manage reproductive cycles in gilts and sows. Review of the literature nonetheless reveals that research on kisspeptin and its function in controlling reproduction in pigs has lagged that of other livestock species.

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Section: Oestrogen Feedback and Expression Of Kisspeptincontrasting

confidence: 71%

Section: Structural Organization Of Kisspeptin Neurons In the Hypothamentioning

confidence: 99%

Review: kisspeptin and reproduction in the pig

Lents

2019

Animal

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“…One study in pigs (Ieda et al 2014) found that KISS1 mRNA levels in the arcuate nucleus did not change Journal of Endocrinology across puberty. By contrast, there is evidence that, in the sheep, kisspeptin expression increases across puberty.…”

Section: Pubertymentioning

confidence: 99%

Kisspeptin and the regulation of the reproductive axis in domestic animals

Scott

Rose

Gunn

et al. 2019

Journal of Endocrinology

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The control of reproductive processes involves the integration of a number of factors from the internal and external environment, with the final output signal of these processes being the pulsatile secretion of gonadotrophin-releasing hormone (GnRH) from the hypothalamus. These factors include the feedback actions of sex steroids, feed intake and nutritional status, season/photoperiod, pheromones, age and stress. Understanding these factors and how they influence GnRH secretion and hence reproduction is important for the management of farm animals. There is evidence that the RF-amide neuropeptide, kisspeptin, may be involved in relaying the effects of these factors to the GnRH neurons. This paper will review the evidence from the common domestic animals (sheep, goats, cattle, horses and pigs), that kisspeptin neurons are (i) regulated by the factors listed above, (ii) contact GnRH neurons and (iii) involved in the regulation of GnRH/gonadotrophin secretion.

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“…Increased KISS1 expression in the early stages of puberty has been observed in both male and female monkeys and rats (Bentsen et al, 2010; Shahab et al, 2005; Takase et al, 2009). No change in KISS1 expression was observed in the ARC of female pigs across puberty (Ieda et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Expression of genes for Kisspeptin ( KISS1 ), Neurokinin B ( TAC3 ), Prodynorphin ( PDYN ), and gonadotropin inhibitory hormone ( RFRP ) across natural puberty in ewes

Smith

Henry

et al. 2020

Physiol Rep

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Expression of particular genes in hypothami of ewes was measured across the natural pubertal transition by in situ hybridization. The ewes were allocated to three groups (n = 4); prepubertal, postpubertal and postpubertally gonadectomized (GDX). Prepubertal sheep were euthanized at 20 weeks of age and postpubertal animals at 32 weeks. GDX sheep were also euthanized at 32 weeks, 1 week after surgery. Expression of KISS1, TAC3, PDYN in the arcuate nucleus (ARC), RFRP in the dorsomedial hypothalamus and GNRH1 in the preoptic area was quantified on a cellular basis. KISS1R expression by GNRH1 cells was quantified by double‐label in situ hybridization. Across puberty, detectable KISS1 cell number increased in the caudal ARC and whilst PDYN cell numbers were low, numbers increased in the rostral ARC. TAC3 expression did not change but RFRP expression/cell was reduced across puberty. There was no change across puberty in the number of GNRH1 cells that expressed the kisspeptin receptor (KISS1R). GDX shortly after puberty did not increase expression of any of the genes of interest. We conclude that KISS1 expression in the ARC increases during puberty in ewes and this may be a causative factor in the pubertal activation of the reproductive axis. A reduction in expression of RFRP may be a factor in the onset of puberty, removing negative tone on GNRH1 cells. The lack of changes in expression of genes following GDX suggest that the effects of gonadal hormones may differ in young and mature animals.

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<i>KISS1</i> Gene Expression in the Developing Brain of Female Pigs in Pre- and Peripubertal Periods

Cited by 22 publications

References 27 publications

Review: kisspeptin and reproduction in the pig

Review: kisspeptin and reproduction in the pig

Kisspeptin and the regulation of the reproductive axis in domestic animals

Expression of genes for Kisspeptin ( KISS1 ), Neurokinin B ( TAC3 ), Prodynorphin ( PDYN ), and gonadotropin inhibitory hormone ( RFRP ) across natural puberty in ewes

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