&lt;i&gt;Juniperus chinensis&lt;/i&gt; Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice

Jegal, Jonghwan; Park, No-June; Park, Sang-a; Bong, Sim-Kyu; Jegal, Hyun; Kim, Su‐Nam; Yang, Min

doi:10.1248/bpb.b17-00818

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Notably, many flavonoids are well-known NF-κB inhibitors and also possess inhibitory activity on different PDE isoforms, including PDE4 [45,46]. Among them, the flavone apigenin was shown, on the one hand, to non-selectively inhibit PDE4 [47] and, on the other, to reduce the levels of proallergic cytokines in models of asthma and atopic dermatitis [48,49]; however, a causal link between the two effects could not be established. For these reasons, we decided to further correlate the effect of RNLE with that of crisaborole (0.5 µ M), a topical PDE4 inhibitor approved in 2016 by FDA for the treatment of AD.…”

Section: Rnle Inhibits Tnf-α/il-4-induced Tslp Release In Differentiated Hacat Cells With a Camp-independent Mechanismmentioning

confidence: 99%

Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

et al. 2021

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Ribes nigrum L. (blackcurrant) leaf extracts, due to high levels of flavonols and anthocyanins, have been shown to exhibit beneficial effects in inflammatory diseases. However, whereas their traditional use has been investigated and validated in several models of inflammation and oxidative stress, the possible impact on skin disorders is still largely unknown. The purpose of this work was to elucidate the effects of R. nigrum leaf extract (RNLE) on keratinocyte-derived inflammatory mediators, elicited by a Th1 or Th2 cytokine milieu. HaCaT cells were challenged with TNF-α, either alone or in combination with the costimulatory cytokines IFN-γ or IL-4, and the release of proinflammatory cytokines and mediators (IL-8, IL-6, s-ICAM-1, and TSLP) was evaluated. The results showed that RNLE preferentially interferes with IFN-γ signaling, demonstrating only negligible activity on TNF-α or IL-4. This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-α/IL-4-induced TSLP release in a cAMP-independent manner. These results suggest that RNLE could have an antiallergic effect mediated in keratinocytes via mechanisms beyond histamine involvement. In conclusion, the discovery of RNLE preferential activity against IFN-γ-mediated inflammation suggests potential selectivity against Th1 type response and the possible use in Th1 inflammatory diseases.

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Section: Rnle Inhibits Tnf-α/il-4-induced Tslp Release In Differentiated Hacat Cells With a Camp-independent Mechanismmentioning

confidence: 99%

Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

et al. 2021

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The Complementary Effect Between Garlic, Cinnamon and Juniper Essential Oils on Productive Performance, Digestibility and Blood Parameters of New-Zealand White Rabbits

Abedo

El-Nomeary

Salman

et al. 2020

Egyptian Journal of Nutrition and Feeds

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total of 72 male New Zealand White (NZW) rabbits after weaning were allotted among 4 groups with 3 replications, six rabbits each, using a completely randomized design, for 45 d. The 1 st group (control, R1) was fed a basal diet without addition. The 2 nd , 3 rd and 4 th groups were fed a basal diet supplemented with 0.25 mg of garlic oil (GAR) plus 0.25 mg of cinnamon oil (CIN, R2); 0.25 mg of GAR plus 0.25 mg of juniper oil (JUN,R3) and 0.25 mg of GAR plus the mixture of CIN and JUN at the level of 0.125 mg for each / kg diet v/w (R4), respectively. The results indicated that dietary rabbit's GAR plus a mixture of CIN and JUN significantly increased the total bacterial count by 44.4% and the cellulolytic bacteria by 70%, respectively, compared to the control group. Dietary rabbit's GAR plus CIN (R2) and JUN (R3) significantly improved the DM digestibility by 41.7 and 29.1% as well as increased the EE digestibility by 18.7 and 13.9%, respectively compared to the control group. The mixture treatment (R4) significantly increased the final body weight by 11.9%, the total body weight gain by 7.5%, the average daily body weight gain by 51.5% and feed conversion ratio by 17.2% compared to the control group. The mixture treatment (R4) significantly decreased the triglycerides by 54.6%, total cholesterol by 67.5, LDL by 52.5% followed by (R3) treatment by 53, 32.4 and 79.2%, respectively. Same reductions were detected in (R2) treatment by 49.7, 33.2 and 30.9%, respectively compared to the control group. The mixture treatment (R4) significantly increased the carcass weight (with or without edible offals) by 11.9 or by 12.6%, respectively compared to the control group. In conclusion, dietary rabbit's GAR plus a mixture of CIN and JUN significantly increased caecum microbial count and further improved nutrients digestibility, growth performance, carcass characteristics complemented with decreasing serum lipids profile.

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Plant Extracts as a Natural Source of Bioactive Compounds and Potential Remedy for the Treatment of Certain Skin Diseases

Sitarek

Kowalczyk

Wieczfińska

et al. 2020

CPD

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: Skin ailments present a major health burden in both developed and undeveloped countries. Maintaining healthy skin is important for a healthy body. Medicinal plants have long provided reliable therapy in the treatment of skin diseases in humans through a diverse range of bioactive molecules. Skin diseases may have a various basis, or may be genetically determined; Together, they constitute approximately 34% of all occupational diseases encountered in people of all ages. Of these, melanoma is one of the most dangerous forms, with very poor prognosis for patients if it is diagnosed too late. This review of literature over the past five years examines the role and utilities of plant extracts in treating various skin diseases such as atopic dermatitis, acne or melanoma with various potential mechanisms of action.

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<i>Juniperus chinensis</i> Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice

Cited by 3 publications

References 28 publications

Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

The Complementary Effect Between Garlic, Cinnamon and Juniper Essential Oils on Productive Performance, Digestibility and Blood Parameters of New-Zealand White Rabbits

Plant Extracts as a Natural Source of Bioactive Compounds and Potential Remedy for the Treatment of Certain Skin Diseases

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