<i>In Vivo</i> Vibration Measurement of Middle Ear Structure Using Doppler Optical Coherence Tomography: Preliminary Study

Abstract

The TM vibration under sound stimulation with frequencies from 1 kHz to 4 kHz in normal and pathologic conditions was demonstrated using signal demodulation method in in vivo condition. The OCT technology could be helpful for functional and structural assessment as an optional modality.

Functional assessment of moisture influenced cadaveric tympanic membrane using phase shift‐resolved optical Doppler vibrography

“…An optical frequency domain imaging (OFDI) technology based interferogram, formed by combining the retro‐reflected light from the sample and the reference arms, was collected via a 4096‐pixels CCD line scan camera (spL‐140 km, Basler, Germany) integrated optical spectrometer. Further details of the OFDI system can be found in . Although signal and image processing procedures, such as fast Fourier transformation (FFT), logarithmic compensation and gray scale conversion of the OFDI system are made in real‐time, a GPU accelerated mode using a graphics card (GeForce GTX 480, 700‐MHz clock rate, 480 compute unified device architecture [CUDA] processors; NVIDIA, Santa Clara, CA) was used for real‐time ODV signal and image processing to further enhance the data acquisition speed of the system .…”

“…In addition, its sensitivity to a high velocity permits the imaging of microcirculation in blood vessels, which is more challenging using conventional Doppler ultrasound methods. OCT and ODT vibrography have been applied in the otolaryngologic field including the diagnosis of middle‐ear related diseases . The enhanced data acquisition speed of the above methods has the potential to describe the oscillatory behavior of TM surface in a phase‐sensitive manner.…”

Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography

“…The loudspeaker had a power output of 15 W and a measured sound volume of 92 dB. We had previously utilized a similar optical setup and DOCT algorithm for blood flow measurement in blood vessels for a small animal model which had been inoculated with squamous cell carcinoma [31], and for in vivo vibration measurement of middle ear structure [12]. Figure 2 shows the DOCT system software algorithm that controls the hardware modules using a multithreading algorithm for acquiring the raw signal, copy, and transfer of processed signals and image data output, respectively.…”

In Situ Characterization of Micro-Vibration in Natural Latex Membrane Resembling Tympanic Membrane Functionally Using Optical Doppler Tomography

“…Moreover, the ODT technique has been used for angiography, as it can measure the blood flow while imaging the monolayer structure [40,41]. Furthermore, ODT algorithms were developed and actively studied for skin tissues, ophthalmic angiography [42] and human TM [43][44][45][46]. Middle ear anatomy and functions were investigated using phase-sensitive, OCT-integrated video otoscopy in a previous attempt.…”