&lt;i&gt;In vitro&lt;/i&gt; effect of lysophosphatidic acid on proliferation, invasion and migration of human ovarian cancer cells

Wang, Qingfu; Zhu, Lixin; Qin, Aiping; Chen, Tiefeng; Li, Jinpen; Wu, Beitai; Yu, Xiao Fang; Lai, Zongan; Xie, Weixiong

doi:10.4314/tjpr.v17i2.4

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…CXCL12 can regulate directional migration, invasion, and angiogenesis of tumor cells and is found at high levels in the ascites fluid of ovarian cancer patients. However, another group found that LPA stimulated proliferation but not CXCL12 production in CAOV3 cells [98]. Other groups have reported that LPA induces IL-8, an angiogenic factor that contributes to ovarian cancer metastasis in ovarian cancer cell lines [99].…”

Section: Ovarian Cancermentioning

confidence: 99%

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?

Balijepalli

Sitton

Meier

2021

Cells

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Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great interest from a therapeutic viewpoint. The numerous LPA receptors (LPARs) are coupled to a variety of G proteins, and more than one LPAR is typically expressed on any given cell. While the individual receptors signal through conventional GPCR pathways, LPA is particularly efficacious in stimulating cancer cell proliferation and migration. This review addresses the mechanistic aspects underlying these pro-tumorigenic effects. We provide examples of LPA signaling responses in various types of cancers, with an emphasis on those where roles have been identified for specific LPARs. While providing an overview of LPAR signaling, these examples also reveal gaps in our knowledge regarding the mechanisms of LPA action at the receptor level. The current understanding of the LPAR structure and the roles of LPAR interactions with other receptors are discussed. Overall, LPARs provide insight into the potential molecular mechanisms that underlie the ability of individual GPCRs (or combinations of GPCRs) to elicit a unique spectrum of responses from their agonist ligands. Further knowledge of these mechanisms will inform drug discovery, since GPCRs are promising therapeutic targets for cancer.

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Section: Ovarian Cancermentioning

confidence: 99%