<i>Coriandrum sativum</i> L. Protects Human Keratinocytes from Oxidative Stress by Regulating Oxidative Defense Systems

Abstract

Background: Oxidative radicals are major environmental causes of human skin damage. Oxidative defense factors, including nuclear factor erythroid-derived 2-related factor 2 (Nrf2), are centrally involved in repairing skin cells or protecting them from oxidative damage. Coriandrum sativum L. (coriander; CS) is a commonly consumed food and a traditional phytomedicine in Asia and Europe. In this study, we examined the protective effects of a standardized CS leaf extract against oxidative stress in human HaCaT keratinocytes. Methods and Results: CS significantly and dose-dependently protected cells against reduced cell viability caused by H₂O₂-induced damage, as assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Other assays demonstrated that CS protected HaCaT cells by increasing the levels of glutathione and activities of oxidative defense enzymes, such as superoxide dismutase and catalase. Moreover, it increased the expression of activated Nrf2, which plays a crucial role in protecting skin cells against oxidative stress. Conclusion: These results suggest that CS protects human keratinocytes from H₂O₂-induced oxidative stress through antioxidant effects.

Sauchinone, a Lignan from <i>Saururus chinensis</i>, Protects Human Skin Keratinocytes against Ultraviolet B-Induced Photoaging by Regulating the Oxidative Defense System

“…19) Sauchinone also seemed to ameliorate lipid hydroperoxide, as demonstrated by a reduction in the production of malondialdehyde. 8,21) While much previous research on sauchinone has focused on antiinflammatory and antioxidant effects in hepatocytes, less is known regarding skin disease. We first demonstrated that sauchinone protected keratinocytes, illustrated by protection against UVB-induced photoaging, by inhibiting MAPK signaling pathways via ROS generation.…”

A review on chemical constituents and pharmacological activities of Coriandrum sativum

“…Other assays demonstrated that CS protected HaCaT cells by increasing the levels of glutathione and activities of oxidative defense enzymes, such as superoxide dismutase and catalase. Moreover, it increased the expression of activated Nrf2, which plays a crucial role in protecting skin cells against oxidative stress [171].…”

Cutaneous Carotenoids: The Mirror of Lifestyle?

“…This, in turn, may result in skin aging, immunosuppression, development of skin diseases and even skin cancer [5,6,7,8,9]. But there are also endogenous sources of radical formation; these sources include illness, smoking, alcohol consumption and private as well as professional stress [10,11,12,13,14]. The human body has developed a protective mechanism against the destructive action of free radicals in the form of an antioxidant defence system [15,16].…”