Cutaneous Carotenoids: The Mirror of Lifestyle?

Lademann, Juergen; Köcher, W.; Yu, Ruoxi; Meinke, Martina C.; Lee, B. Na; Jung, Sora; Sterry, Wolfram; Darvin, Maxim E.

doi:10.1159/000357222

Cited by 24 publications

(24 citation statements)

References 29 publications

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“…An imbalance between the body's antioxidant defense system and the reactive metabolites induces several physiological processes within the body which can lead to e.g., cell aging, tissue damage or cancer [6][7][8][9]. If a strong interference between ROS and cells exists, programmed cell death (apoptosis) can be initiated [3,10,11]. Thereby the ROS can destroy several biomolecules in their function, such as lipids, proteins, enzymes or nucleic acid, promoting, inter alia, a peroxidation of the mitochondrial membrane lipids, leading to a mitochondrial permeability transition (MPT).…”

Section: Introductionmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging radicals, especially reactive oxygen species (ROS). Made up of one or two unpaired electrons, ROS are free radicals that are highly reactive and can attack other metabolites. By using electron paramagnetic resonance (EPR) spectroscopy, it is possible to measure paramagnetic substances such as free radicals. Therefore the dermal antioxidant activity can be determined by applying semi-stable radicals onto the skin and measuring the antioxidant-induced radical scavenging activity in the skin. In recent years, EPR has been OPEN ACCESS Cosmetics 2015, 2 287 developed as a spectroscopic method for determining the antioxidant status in vivo. Several studies have shown that an additional uptake of dietary supplements, such as carotenoids or vitamin C in physiological concentrations, provide a protective effect against free radicals. Using the EPR technique it could be demonstrated that the radical production in stress situations, such as irradiation with infrared and visible light, was reduced with time. However, not only the oral uptake of antioxidants, but also the topical application of antioxidants, e.g., a hyperforin-rich cream, is very useful against the development of oxidative stress. Regular application of a hyperforin-rich cream reduced radical formation. The skin lipids, which are very important for the barrier function of the skin, were also stabilized.

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Section: Introductionmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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“…If the maximum individual rate constant increase of 18% in the control group is taken as cutoff value for the responding status, half of the subjects in both green tea groups could be classified as nonresponders. However, the decrease in the rate constant observed in 4 of 5 participants affected by illness during the study indicates a negative influence of illness on the radical scavenging capacity of the skin, possibly due to a decrease in cutaneous antioxidants as reported in previous studies [65,66]. Furthermore, considering that biomarkers of green tea consumption were not monitored in blood or urine, it is not clear how many of the nonresponders were noncompliant.…”

Section: Discussionmentioning

confidence: 78%

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Megow¹,

Darvin²,

Meinke³

et al. 2017

Skin Pharmacol Physiol

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Background: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. Methods: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin. Thirty-two participants who met the inclusion criteria were randomized to consume 3 cups per day of either Benifuuki tea, Yabukita tea, or water (control group) for 2 weeks. Electron paramagnetic resonance (EPR) spectroscopy was applied to measure the radical scavenging capacity of the skin in vivo before and after the intervention. Results: Both Yabukita and Benifuuki tea led to an increase in the radical scavenging activity of the skin by 28 and 29%, respectively, and the difference was significant when compared to the control group. Benifuuki tea, previously reported to be superior in bioavailability due to a highly absorbable methylated catechin, did not prove to be more effective than the common Yabukita tea. Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.

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“…Skin aging, immunosuppression and also skin cancer can be the consequences of all these processes [9,10,11]. The human organism has developed a protection system against the destructive action of the free radicals in the form of antioxidants [12,13]. The antioxidants in human tissue are able to neutralize free radicals before they are in a position to damage the tissue.…”

Section: Introductionmentioning

confidence: 99%

Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin

Lademann

Vergou²,

Darvin

et al. 2016

Skin Pharmacol Physiol

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Background: The formation of free radicals in human skin by solar ultraviolet radiation is considered to be the main reason for extrinsic skin aging. The antioxidants in human tissue represent an efficient protection system against the destructive action of these reactive free radicals. In this study, the parameters of the skin, epidermal thickness, stratum corneum moisture, elasticity and wrinkle volume, were determined before and after the treatment with antioxidant- or placebo-containing tablets and creams. Methods: The study included 5 groups of 15 volunteers each, who were treated for 2 months with antioxidant-containing or placebo tablets, creams or a combination of antioxidant-containing tablets and cream. The skin parameters were measured at time point 0 and at week 8 utilizing ultrasound for the determination of epidermal thickness, a corneometer for stratum corneum moisture measurements, skin profilometry for quantifying the wrinkle volume and a cutometer for determining the elasticity. Results: The verum cream had a positive influence on epidermal thickness, elasticity and skin moisture, but the verum tablets improved the epidermal thickness only. The combined application of verum tablets and creams led to a significant improvement of all investigated skin parameters, whereas the application of placebo tablets or cream did not influence any parameters. Conclusion: The topical and oral supplementation of antioxidants can be an instrument to improve several skin parameters and potentially counteract or decelerate the process of extrinsic skin aging.

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Cutaneous Carotenoids: The Mirror of Lifestyle?

Cited by 24 publications

References 29 publications

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin

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