&lt;i&gt;CAPN10&lt;/i&gt; SNP43 G&amp;gt;A gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 9353 participants

Li, Yanyan; Gong, Ge; Geng, Hong‐yu; Yang, Zhaohui; Zhou, Chuanwei; Xu, Jian; Qian, Yun; Wang, Xiangming; Chen, Ailing

doi:10.1507/endocrj.ej14-0297

Cited by 8 publications

(4 citation statements)

References 29 publications

(39 reference statements)

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“…Single-nucleotide polymorphism rs3792267polymorphism in CAPN10 has been examined on the effect of regulating insulin sensitivity and CAPN10 mRNA levels [33]. However, divergent results were reported and gave a heterogeneous picture owing to racial or regional differences [31,32,34,35]. Our study revealed that the A allele of rs3792267 of CAPN10 was significantly associated with T2DM in Uyghur participants (P = 0.002, adjusted for age, gender and BMI) ( Table 2).…”

Section: Study Findingsmentioning

confidence: 71%

“…also reported association of the A allele with high risk of T2DM in Uyghur population . Yet, some studies showed two opposite trends of statistical significance of the G‐ and A‐allele towards T2DM in certain population . This discrepancy suggested that the association should be population‐specific due to the differential allelic frequencies across different human ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

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The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CAPN10,APM1 and FUT6 genes

Zhao

Mamatyusupu

Wang

et al. 2016

J Cellular Molecular Medi

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Genome‐wide association studies have successfully identified over 70 loci associated with the risk of type 2 diabetes mellitus (T2DM) in multiple populations of European ancestry. However, the risk attributable to an individual variant is modest and does not yet provide convincing evidence for clinical utility. Association between these established genetic variants and T2DM in general populations is hitherto understudied in the isolated populations, such as the Uyghurs, resident in Hetian, far southern Xinjiang Uyghur Autonomous Region, China. In this case–control study, we genotyped 13 single‐nucleotide polymorphisms (SNPs) at 10 genes associated with diabetes in 130 cases with T2DM and 135 healthy controls of Uyghur, a Chinese minority ethnic group. Three of the 13 SNPs demonstrated significant association with T2DM in the Uyghur population. There were significant differences between the T2DM patients and controls in the risk allele distributions of rs3792267 (CAPN10) (P = 0.002), rs1501299 (APM1) (P = 0.017), and rs3760776 (FUT6) (P = 0.031). Allelic carriers of rs3792267‐A, rs1501299‐T, and rs3760776‐T had a 2.24‐fold [OR (95% CI): 1.35–3.71], 0.59‐fold [OR (95% CI): 0.39–0.91], 0.57‐fold [OR (95% CI): 0.34–0.95] increased risk for T2DM respectively. We further confirmed that the cumulative risk allelic scores calculated from the 13 susceptibility loci for T2DM differed significantly between the T2DM patients and controls (P = 0.001), and the effect of obesity/overweight on T2DM was only observed in the subjects with a combined risk allelic score under a value of 17. This study observed that the SNPs rs3792267 in CAPN10, rs1501299 in APM1, and rs3760776 in FUT6 might serve as potential susceptible biomarkers for T2DM in Uyghurs. The cumulative risk allelic scores of multiple loci with modest individual effects are also significant risk factors in Uyghurs for T2DM, particularly among non‐obese individuals. This is the first investigation having observed/found genetic variations on genetic loci functionally linked with glycosylation associated with the risk of T2DM in a Uyghur population.

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Section: Study Findingsmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CAPN10,APM1 and FUT6 genes

Zhao

Mamatyusupu

Wang

et al. 2016

J Cellular Molecular Medi

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“…[ 7 , 19 , 23 ] The inherent genetic differences between ethnic group is to be responsible, just like the opposite trends of the calpain-10 rs3792267 allele and T2DM between the Uyghur and Chinese populations. [ 24 , 25 ] In 2011, Han et al [ 26 ] conducted a meta analysis to explore the association between SNPs of adiponectin gene and T2DM, and the results showed that the adiponectin rs266729 G allele was a risk factor for T2DM, with the pooled OR (95% CI) of 1.07 (1.03, 1.11, P = .001) for G versus C allele. However, the study did not provide the rs266729 genetic effect on the development of T2DM in different populations.…”

Section: Discussionmentioning

confidence: 99%

The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus

Sun

Liu

Chen³

et al. 2017

Medicine

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Genome-wide association studies and meta-analyses indicate that the polymorphism of rs266729 in adiponectin gene increases the risk of type 2 diabetes mellitus (T2DM); however, these study methods have not been able to identify the underlying genetic effect on the development of T2DM. A genetic model-free approach was conducted to determine the underlying genetic model of inheritance of T2DM because of rs266729 in adiponectin gene.We searched available studies on the association between the rs266729 in adiponectin gene and T2DM in accordance with the inclusion and exclusion criteria. Based on the information extracted from the studies, generalized odds ratio value (GOR) was used to evaluate whether the rs266729 polymorphism was a risk factor for T2DM. The parameter λ was calculated to estimate the genetic model, which was defined as the quotient of natural logarithm odds ratio of GC to CC divided by the natural logarithm odds ratio of GG to CC. Finally, binary logistic regression analysis was used to calculate the genetic effect of rs266729 on T2DM.Data from 7 studies were included in this meta-analysis. The total number of subjects was 12,323, comprising 5,948 cases and 6,395 controls. Mean (standard deviation) age of cases was 59.50 (11.53), and that of the controls was 53.80 (11.65), whereas the proportion of male was 40.9 and 50.0%, respectively. GOR was 1.13 (1.02, 1.25) and λ was 0.47 (0.29, 0.64). The result of logistic regression indicated that the G allele influenced the development of T2DM in the additive model, whereas the genetic effect was 1.13 (1.06, 1.19). Sources of control populations were the cause of between-study heterogeneity; nonetheless, there was no publication bias among studies.The G allele of rs266729 in adiponectin gene increases the risk of T2DM through an additive genetic model with an effect of 1.13 (1.06, 1.19).

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“…CALPIN-10 gene located at 2q37 and spans 31 kb and contains 15 exons, constituted by 672 amino acids; it is in the third intron region. 15 CALPIN-10 gene was the first diabetes gene identified by cloning and encodes the calpain-10 protein. 12 Calpain-10 protein is involved in the secreting pancreatic islands and action of insulin, and is associated with adipocytes.…”

Section: Introductionmentioning

confidence: 99%

Association between type 2 diabetes mellitus, biochemical factors and UCSNP-43 polymorphisms of CALPIN-10 gene in patients with atherosclerosis of coronary artery disease in Southern Iran population

Senemar

Edraki

Toosi

2016

J Cardiovasc Thorac Res

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Introduction: Genetic variations in the calpain 10 gene (CALPIN-10), single nucleotide polymorphisms-43 (SNP-43), have increased the risk of type 2 diabete mellitus (T2DM) and coronary artery disease (CAD). Methods: We studied the control and CAD groups for association of association of SNP-43 in the CALPIN-10 gene with T2DM and other risk factors of its complications. Overall, we examined 452 individuals, 224 patients with CAD and 228 healthy subjects for CAD in Iranian population. All the subjects were genotyped for the CALPIN-10, SNP-43 by polymorphism chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods, using biochemical methods to detect fasting glucose and other biochemical factors in the blood sample. We assessed frequencies of SNP-43 alleles between CAD and normal population groups. Results: In CAD patients, the GG allele was significantly associated with T2DM and GG allele was causing high level of glucose. But in control group, there was no relationship between them. Between clinical and biochemical risk factors with different genotypes there was no significant difference in the compared group. Conclusion: The results of our study suggest no significant association between SNP-43 and the risk of T2DM. In other words, CALPIN-10 did not show a major diabetes gene pool capacity in normal southern Iranian population.

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<i>CAPN10</i> SNP43 G>A gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 9353 participants

Cited by 8 publications

References 29 publications

The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CAPN10,APM1 and FUT6 genes

The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CAPN10,APM1 and FUT6 genes

The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus

Association between type 2 diabetes mellitus, biochemical factors and UCSNP-43 polymorphisms of CALPIN-10 gene in patients with atherosclerosis of coronary artery disease in Southern Iran population

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