The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus

Abstract

Genome-wide association studies and meta-analyses indicate that the polymorphism of rs266729 in adiponectin gene increases the risk of type 2 diabetes mellitus (T2DM); however, these study methods have not been able to identify the underlying genetic effect on the development of T2DM. A genetic model-free approach was conducted to determine the underlying genetic model of inheritance of T2DM because of rs266729 in adiponectin gene.We searched available studies on the association between the rs266729 in adiponectin gene and T2DM in accordance with the inclusion and exclusion criteria. Based on the information extracted from the studies, generalized odds ratio value (GOR) was used to evaluate whether the rs266729 polymorphism was a risk factor for T2DM. The parameter λ was calculated to estimate the genetic model, which was defined as the quotient of natural logarithm odds ratio of GC to CC divided by the natural logarithm odds ratio of GG to CC. Finally, binary logistic regression analysis was used to calculate the genetic effect of rs266729 on T2DM.Data from 7 studies were included in this meta-analysis. The total number of subjects was 12,323, comprising 5,948 cases and 6,395 controls. Mean (standard deviation) age of cases was 59.50 (11.53), and that of the controls was 53.80 (11.65), whereas the proportion of male was 40.9 and 50.0%, respectively. GOR was 1.13 (1.02, 1.25) and λ was 0.47 (0.29, 0.64). The result of logistic regression indicated that the G allele influenced the development of T2DM in the additive model, whereas the genetic effect was 1.13 (1.06, 1.19). Sources of control populations were the cause of between-study heterogeneity; nonetheless, there was no publication bias among studies.The G allele of rs266729 in adiponectin gene increases the risk of T2DM through an additive genetic model with an effect of 1.13 (1.06, 1.19).

Adipokines and Aging: Findings From Centenarians and the Very Old

“…This was demonstrated because subjects with GG genotype in rs266729 exhibited higher plasma adiponectin levels than those of other genotypes in some replicated studies, including those hailing from different ethnic backgrounds ( 40 , 41 ). This SNP is supposed to be the most promising genetic variation related to adiponectin level and also the risk of MS ( 42 ), T2DM ( 43 ), and insulin resistance ( 41 ). Another SNP located in the promoter region of ADIPOQ , rs1656930, was highly connected with the adiponectin levels of elderly Japanese subjects ( 44 ).…”

Gene Polymorphism of Adiponectin SNP + 45 with Reference to Thyroid Status - A Comparative Study among Non-Obese, Overweight and Obese Type 2 Diabetics

“…Whereas, the results of a meta-analysis suggested that SNP + 45 G allele might be a susceptibility allele for T2DM in the population, as elaborated by Li and Li [46]. In another meta-analysis report, the results indicated the susceptibility of obesity as a function of adiponectin gene polymorphism [47].…”

Associations of maternal diabetes mellitus and adiponectin gene polymorphisms with congenital heart disease in offspring

“…Recent years, adiponectin ( APM1 ) gene has been widely studied in type 2 DM (T2DM) [ 16 – 19 ] . The APM1 gene was located in the chromosomal region at 3q27, and was responsible for encoding adiponectin.…”