&lt;i&gt;Bmp7&lt;/i&gt; Regulates Germ Cell Proliferation in Mouse Fetal Gonads

Ross, Andrea J.; Munger, Steven C.; Capel, Blanche

doi:10.1159/000100034

Cited by 63 publications

(44 citation statements)

References 53 publications

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“…Consistent with this, loss of function of the receptor for FGF7, FGFR2-3b results in reduced germ cell numbers (Takeuchi et al, 2005). In addition, BMPs regulate PGC numbers and motility in culture (Dudley et al, 2007;Ross et al, 2007). BMPs are also required for regulation of pluripotency in ES cells (Ying et al, 2003) and for recruitment of PGCs from the proximal epiblast during germ line specification (Lawson et al, 1999;de Sousa Lopes et al, 2004).…”

Section: Survival and Proliferation: Key Aspects Of Early Germ Cell Dmentioning

confidence: 74%

Foetal germ cells: striking the balance between pluripotency and differentiation

Western¹

2009

Int. J. Dev. Biol.

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Section: Survival and Proliferation: Key Aspects Of Early Germ Cell Dmentioning

confidence: 74%

Foetal germ cells: striking the balance between pluripotency and differentiation

Western¹

2009

Int. J. Dev. Biol.

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“…1). In in vivo studies, Bmp7 null mice showed a reduction of germ cells at 11.5 dpc (Ross et al 2007). RNA-seq studies showed that pre-granulosa cells express Bmp2 and Bmp4 during 11.5-13.5 dpc (Jameson et al 2012) (Fig.…”

Section: Germ Cell Proliferation and Cyst Formationmentioning

confidence: 91%

Disorganization of the germ cell pool leads to primary ovarian insufficiency

Kawashima

Kawamura

2017

Reproduction

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The mammalian ovary is an organ that controls female germ cell development, storing them and releasing mature oocytes for transporting to the oviduct. During the fetal stage, female germ cells change from a proliferative state to meiosis before forming follicles with the potential for the growth of surrounding somatic cells. Understanding of molecular and physiological bases of germ cell development in the fetal ovary contributed not only to the elucidation of genetic disorders in primary ovarian insufficiency (POI), but also to the advancement of novel treatments for patients with POI. Accumulating evidence indicates that mutations in NOBOX, DAZL and FIGLA genes are associated with POI. In addition, cell biology studies revealed the important roles of these genes as essential translational factors for germ cell development. Recent insights into the role of the PI3K (phosphatidylinositol 3-kinase)-AKT signaling pathway in primordial follicle activation allowed the development of a new infertility treatment, IVA (in vitro activation), leading to successful pregnancy/delivery in POI patients. Furthermore, elucidation of genetic dynamics underlying female germ cell development could allow regeneration of oocytes from ES (embryonic stem)/iPS (induced pluripotent stem) cells in mammals. The purpose of this review is to summarize basic findings related to female germ cell development and potential clinical implications, especially focusing on POI etiologies. We also summarize evolving new POI therapies based on IVA as well as oocyte regeneration.Reproduction (2017) 153 R205-R213

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“…Bone morphogenetic protein (Bmp) and RA signalling pathways regulate Msx gene expression in several tissues . Interestingly, expression of Bmp2, Bmp4 and Bmp7 increases in foetal mouse ovaries between 11.5 dpc and 13.5 dpc (Ross et al, 2007). Moreover, upregulation of MSX2 expression has recently been described following BMP4 treatment in the human foetal ovary in organotypic culture, and correlated with an increase in primordial germ cell apoptosis (Childs et al, 2010).…”

Section: Introductionmentioning

confidence: 96%

Msx1 and Msx2 promote meiosis initiation

et al. 2011

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SUMMARYThe mechanisms regulating germ line sex determination and meiosis initiation are poorly understood. Here, we provide evidence for the involvement of homeobox Msx transcription factors in foetal meiosis initiation in mammalian germ cells. Upon meiosis initiation, Msx1 and Msx2 genes are strongly expressed in the foetal ovary, possibly stimulated by soluble factors found there: bone morphogenetic proteins Bmp2 and Bmp4, and retinoic acid. Analysis of Msx1/Msx2 double mutant embryos revealed a majority of undifferentiated germ cells remaining in the ovary and, importantly, a decrease in the number of meiotic cells. In vivo, the Msx1/Msx2 double-null mutation prevented full activation of Stra8, a gene required for meiosis. In F9 cells, Msx1 can bind to Stra8 regulatory sequences and Msx1 overexpression stimulates Stra8 transcription. Collectively, our data demonstrate for the first time that some homeobox genes are required for meiosis initiation in the female germ line.

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<i>Bmp7</i> Regulates Germ Cell Proliferation in Mouse Fetal Gonads

Cited by 63 publications

References 53 publications

Foetal germ cells: striking the balance between pluripotency and differentiation

Foetal germ cells: striking the balance between pluripotency and differentiation

Disorganization of the germ cell pool leads to primary ovarian insufficiency

Msx1 and Msx2 promote meiosis initiation

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