&lt;em&gt;SMAGP&lt;/em&gt; a novel biomarker of cervical cancer development and progression

Jia, Yongqin; Li, Haiyu; Liu, Geli; Song, Fangzhou

doi:10.2147/ott.s175808

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Cervical cancer is the second most common cancer in women, and the majority of female cancer deaths occur in developing countries 1. Various treatments based on the tumor grade and stage, including surgery and radiation therapy, are available for cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway

Wang¹,

Cao²,

Alshwmi³

et al. 2019

OTT

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Background: Increasing evidence suggests that glutathione peroxidase 2 (GPX2) plays important roles in the tumorigenesis and progression of various human cancers, such as colorectal carcinomas and lung adenocarcinomas. However, the role of GPX2 in cervical cancer is unclear. In this study, we identified the role of GPX2 in cervical cancer tissues and cell lines. Materials and methods: The basal mRNA and protein expression of GPX2 in cervical cancer cells and a series of key molecules in the epithelial to mesenchymal transition (EMT) and WNT/β-catenin pathways were examined via real time fluorescence quantitative PCR (qRT-PCR) and Western blot assays. The biological phenotype of the cervical cancer cell lines was detected by the cloning formation and transwell assays, and intracellular reactive oxygen species (ROS) levels were detected by flow cytometry. Finally, the GPX2 expression level in 100 clinical cervical tissues was examined by immunohistochemistry. Results: We found that GPX2 was highly expressed in cervical cancer tissues compared to normal individuals and promoted the proliferation and metastasis of cervical cancer cells, and this promotion correlated with the activation of EMT and WNT/β-catenin signaling in vitro. GPX2 was determined to reduce apoptotic damage by reducing hydroperoxides. According to the characteristics and verification of GPX2, this series of phenotypes is clearly related to oxidative stress in cells. Furthermore, we verified that GPX2 was highly expressed in cervical cancer tissues and promoted the metastasis of cervical cancer. Conclusion: In summary, we found that GPX2 was highly expressed in cervical cancer cells and promoted the proliferation and metastasis of cervical cancer by affecting oxidative stress. Our study provides a new target for the clinical treatment of cervical cancer.

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Section: Introductionmentioning

confidence: 99%

GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway

Wang¹,

Cao²,

Alshwmi³

et al. 2019

OTT

View full text Add to dashboard Cite

show abstract

“…For instance, CCDC167 was reported to be a regulator of cell cycle and served as a potential therapeutic target in breast cancer ( 75 ). Small Cell Adhesion Glycoprotein (SMAGP) was reported as a biomarker of cervical cancer development and progression ( 76 ).…”

Section: Discussionmentioning

confidence: 99%

MAVI1, an endoplasmic reticulum–localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion

Shi,

Huang,

et al. 2023

Sci. Adv.

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Pattern recognition receptor–mediated innate immunity is critical for host defense against viruses. A growing number of coding and noncoding genes are found to encode microproteins. However, the landscape and functions of microproteins in responsive to virus infection remain uncharacterized. Here, we systematically identified microproteins that are responsive to vesicular stomatitis virus infection. A conserved and endoplasmic reticulum–localized membrane microprotein, MAVI1 (microprotein in antiviral immunity 1), was found to interact with mitochondrion-localized MAVS protein and inhibit MAVS aggregation and type I interferon signaling activation. The importance of MAVI1 was highlighted that viral infection was attenuated and survival rate was increased in Mavi1- knockout mice. A peptide inhibitor targeting the interaction between MAVI1 and MAVS activated the type I interferon signaling to defend viral infection. Our findings uncovered that microproteins play critical roles in regulating antiviral innate immune responses, and targeting microproteins might represent a therapeutic avenue for treating viral infection.

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“…High DVL3 expression is associated with poor prognosis in patients with lung cancer (43,44). SMAGP encodes a transmembrane glycoprotein that plays an important role in tumor invasion and metastasis (45)(46)(47). STRN4 belongs to the striatin family and functions as a co-factor (48), particularly in cancerrelated pathways (49) in prostate (50), lung (51), and gastric (52) cancers.…”

Section: Discussionmentioning

confidence: 99%

CD8+ T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma

Zhang

Guo

et al. 2022

Front. Immunol.

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The presence of infiltrating CD8+ T lymphocytes in the tumor microenvironment of lung adenocarcinoma (LUAD) is correlated with improved patient prognosis, but underlying regulatory mechanisms remain unknown. To identify biomarkers to improve early diagnosis and treatment of LUAD, we downloaded 13 immune cell line-associated datasets from the GEO database. We identified CD8+ T cell-associated genes via weighted correlation network analysis. We constructed molecular subtypes based on CD8+ T cell-associated genes and constructed a multi-gene signature. We identified 252 CD8+ T cell-associated genes significantly enriched in immune function-related pathways and two molecular subtypes of LUAD (immune cluster 1 [IC1] and IC2) using our CD8+ T cell-associated gene signature. Patients with the IC2 subtype had a higher tumor mutation burden and lower immune infiltration scores, whereas those with the IC1 subtype were more sensitive to immune checkpoint inhibitors. Prioritizing the top candidate genes to construct a 10-gene signature, we validated our model using independent GSE and TCGA datasets to confirm its robustness and stable prognostic ability. Our risk model demonstrated good predictive efficacy using the Imvigor210 immunotherapy dataset. Thus, we established a novel and robust CD8+ T cell-associated gene signature, which could help assess prognostic risk and immunotherapy response in LUAD patients.

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<em>SMAGP</em> a novel biomarker of cervical cancer development and progression

Cited by 6 publications

References 24 publications

<p>GPX2 suppression of H<sub>2</sub>O<sub>2</sub> stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway</p>

<p>GPX2 suppression of H<sub>2</sub>O<sub>2</sub> stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway</p>

MAVI1, an endoplasmic reticulum–localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion

CD8+ T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma

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