&lt;b&gt;Synthesis and fungicidal activity of acetyl substituted benzyl disulfides&lt;/b&gt;

Ayodele, E.T.; Olajire, Abass A.; Amuda, Omotayo S.; Oladoye, Sunday

doi:10.4314/bcse.v17i1.61731

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…Ayodele et al carried out the synthesis of unsymmetrical disuldes from thiol, thiourea and thioacetic acid. 10 The method involved the reaction of thiol and thiourea, the latter acts as the S-transfer agent, to form an intermediate S-benzylthioisothiouronium chloride 2 that nally reacts with thioacetic acid (Scheme 4).…”

Section: Methods Of Synthesismentioning

confidence: 99%

“…9 Unsymmetrical disuldes have fungicidal properties. 10 In a recent study, it is revealed that oxidized species of disuldes, such as thiosulnate or thiosulfonate may operate as a rst line of the body's defense against cyanide intoxication. 11 Moreover, disuldes nd vast applications in agro-chemicals, as shown by large varieties of new sulfur-based crop protection chemicals around the world.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in S–S bond formation

Mandal¹,

Basu

2014

RSC Adv.

186

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Section: Methods Of Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent advances in S–S bond formation

Mandal¹,

Basu

2014

RSC Adv.

186

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“…10 Ayodele et al reported the fungicidal activity of benzyl disulfides. 11 In industry, the disulfides have wide applications such as vulcanizing agents for rubbers 12 and in the design of lithium-ion batteries. 13,14 These compounds have a key role in synthetic organic chemistry as they are used for the synthesis of heterocycles.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted oxidative coupling of thiols using polystyrene supported bromoderivatives of 2-oxazolidone

Mathew

Koshy³

2021

Polymers and Polymer Composites

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Polymer-supported reagents have become popular in synthetic organic chemistry over the past decades. But the kinetics of polymer-supported reactions is slow compared to solution phase synthesis because of the poor diffusion of the reactants through the macromolecular polymer matrix. This difficulty can be reduced to a great extent by performing polymer-supported reactions under microwave (MW) conditions. The present work is focussed on the design and development of an innovative, powerful, MW stable and recyclable polymeric reagent prepared by attaching bromoderivative of 2-oxazolidone into the macromolecular matrix of polystyrene. 3% cross-linked polystyrene was prepared by free radical aqueous suspension polymerization technique using tetra ethylene glycol diacrylate as the cross-linking agent and the resulting beads were functionalized by chloromethylation followed by reaction with 2-oxazolidone. Bromine functionality is introduced into the polymer by treating with bromine in carbon tetrachloride. The synthetic utility of the prepared polymeric reagent was demonstrated by the oxidative coupling of thiols to disulfides under MW irradiation. No over oxidation was observed in this protocol and the utilization of polystyrene support simplifies work up and product isolation. The synthesised polymeric reagent displayed good cyclic stability up to five cycles without any substantial decrease in bromine content and satisfactory storage stability under normal laboratory condition. Moreover this may be the first report that uses MW energy for the oxidation of thiols to disulfides using polymer-supported reagents. [Formula: see text]

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“…The synthesis of organic disulphide compounds by the oxidation of thiol derivatives has become a common practice, and quite a few methodologies have been developed in the preparation of these compounds [8] [9]. There has been an increasing demand for novel, ecofriendly and efficient methodologies for the synthesis of organic disulphide compounds owing to their importance in a wide range of pharmaceutical and agro-chemical applications [10] [11].…”

Section: Introductionmentioning

confidence: 99%

Lipase Immobilized on Magnetic Nanoparticles: A New Tool for Synthesis of Disulphide Compounds

Haritha¹,

Meshram²,

Rao³

2015

GSC

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The study describes chemo-enzymatic synthesis of organic disulphide compounds. The reaction was initiated by hydrolysis of thiol acetates using hydrolytic enzyme lipase (PPL) immobilized on to magnetic nanoparticles and subsequent formation of organic disulphide compounds. Lipase was immobilized on to the magnetic nanoparticles by co-precipitation method via epichlorohydrin chitosan cross-linking, under mild and eco-friendly conditions. The immobilized lipase enzyme exhibited broad range of substrate specificity in synthesizing disulphide compounds, which involves both intra and inter-molecular disulphide bond formation under anaerobic conditions. The disulphide compounds synthesized also show a promising antimicrobial activity.

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<b>Synthesis and fungicidal activity of acetyl substituted benzyl disulfides</b>

Cited by 11 publications

References 19 publications

Recent advances in S–S bond formation

Recent advances in S–S bond formation

Microwave-assisted oxidative coupling of thiols using polystyrene supported bromoderivatives of 2-oxazolidone

Lipase Immobilized on Magnetic Nanoparticles: A New Tool for Synthesis of Disulphide Compounds

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