&lt;b&gt;Micronization processes by supercritical fluid technologies: a short review on process design (2008-2012)&lt;/b&gt; - doi: 10.4025/actascitechnol.v35i4.18819

Priamo, Wagner Luiz; Dalmolin, Irede Angela Lucini; Boschetto, Daiane L.; Mezzomo, Natália; Ferreira, Sandra R.S.; Oliveira, J. Vladimir

doi:10.4025/actascitechnol.v35i4.18819

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…This effect can be observed comparing runs 1 to 4 (performed at 35 ºC) with runs 5 to 11 (performed at 40 and 45 ºC). Higher temperatures favor polymer dissolution, leading to a low level of agglomeration and crystal growth in the nucleation process, which leads to an increase in particle size (Aguiar et al, 2016;Cocero and Ferrero, 2002;Priamo et al, 2013). The use of lower temperatures is of course also important for encapsulation of bioactive compounds due to their thermosensitive nature.…”

Section: Particle Characterizationmentioning

confidence: 99%

Poly(hydroxybutyrate-Co-Hydroxyvalerate) Micronization by Solution Enhanced Dispersion by Supercritical Fluids Technique

Aguiar

Magro

Oliveira

et al. 2018

Braz. J. Chem. Eng.

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Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable polymer used for a wide range of applications, especially in biomedical and food industry, for which bioactive compound encapsulation is noteworthy. This work aimed to micronize PHBV by Solution Enhanced Dispersion by Supercritical Fluids technique and evaluate possible changes in polymer crystallinity. A 2 3 Central Composite Design with 3 central points was used to analyze the influence of pressure, temperature and PHBV concentration on particle size produced. Micronized particles were mostly spherical with sizes from 210 to 720 nm, and free of organic solvents. PHBV crystallinity degree was approximately 20% higher when polymer was processed at 8 MPa compared to that processed at 10 and 12 MPa, as well as to the raw polymer. Results suggest versatility in PHBV application according to SEDS process parameters and the possibility of its use in drug delivery systems.

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Section: Particle Characterizationmentioning

confidence: 99%

Poly(hydroxybutyrate-Co-Hydroxyvalerate) Micronization by Solution Enhanced Dispersion by Supercritical Fluids Technique

Aguiar

Magro

Oliveira

et al. 2018

Braz. J. Chem. Eng.

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“…Besides, various supercritical fluids-based techniques have further been developed to overcome the inconsistency within the produced particle sizes along with other drawbacks that could be associated with the conventional production methods [ 54 , 55 , 56 ]. In these techniques, carbon dioxide (scCO 2 ) is the most successfully used supercritical fluid that can be applied either for solvent or, more commonly, for antisolvent co-precipitation of the polymeric carrier along with the drug as fine powders [ 57 , 58 ]. The supercritical fluid-based co-precipitation technique, in addition to the type of polymeric carrier used, produces a bimodal release pattern of the encapsulated drug [ 54 , 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres

Ahmed

Puthussery

Basnett

et al. 2021

IJMS

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This study deals with the process of optimization and synthesis of Poly(3-hydroxybutyrate) microspheres with encapsulated Cl-amidine. Cl-amidine is an inhibitor of peptidylarginine deiminases (PADs), a group of calcium-dependent enzymes, which play critical roles in a number of pathologies, including autoimmune and neurodegenerative diseases, as well as cancer. While Cl-amidine application has been assessed in a number of in vitro and in vivo models; methods of controlled release delivery remain to be investigated. P(3HB) microspheres have proven to be an effective delivery system for several compounds applied in antimicrobial, wound healing, cancer, and cardiovascular and regenerative disease models. In the current study, P(3HB) microspheres with encapsulated Cl-amidine were produced in a size ranging from ~4–5 µm and characterized for surface morphology, porosity, hydrophobicity and protein adsorption, in comparison with empty P(3HB) microspheres. Cl-amidine encapsulation in P(3HB) microspheres was optimized, and these were found to be less hydrophobic, compared with the empty microspheres, and subsequently adsorbed a lower amount of protein on their surface. The release kinetics of Cl-amidine from the microspheres were assessed in vitro and expressed as a function of encapsulation efficiency. There was a burst release of ~50% Cl-amidine in the first 24 h and a zero order release from that point up to 16 days, at which time point ~93% of the drug had been released. As Cl-amidine has been associated with anti-cancer effects, the Cl-amidine encapsulated microspheres were assessed for the inhibition of vascular endothelial growth factor (VEGF) expression in the mammalian breast cancer cell line SK-BR-3, including in the presence of the anti-proliferative drug rapamycin. The cytotoxicity of the combinatorial effect of rapamycin with Cl-amidine encapsulated P(3HB) microspheres was found to be 3.5% more effective within a 24 h period. The cells treated with Cl-amidine encapsulated microspheres alone, were found to have 36.5% reduction in VEGF expression when compared with untreated SK-BR-3 cells. This indicates that controlled release of Cl-amidine from P(3HB) microspheres may be effective in anti-cancer treatment, including in synergy with chemotherapeutic agents. Using controlled drug-delivery of Cl-amidine encapsulated in Poly(3-hydroxybutyrate) microspheres may be a promising novel strategy for application in PAD-associated pathologies.

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Crystal Growth of Anthracene Thin Films on Silicon by Rapid Expansion of Supercritical Solutions (RESS) Using Carbon Dioxide

Fujii

Uchida

2015

J. Chem. Eng. Japan / JCEJ

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<b>Micronization processes by supercritical fluid technologies: a short review on process design (2008-2012)</b> - doi: 10.4025/actascitechnol.v35i4.18819

Cited by 4 publications

References 7 publications

Poly(hydroxybutyrate-Co-Hydroxyvalerate) Micronization by Solution Enhanced Dispersion by Supercritical Fluids Technique

Poly(hydroxybutyrate-Co-Hydroxyvalerate) Micronization by Solution Enhanced Dispersion by Supercritical Fluids Technique

Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres

Crystal Growth of Anthracene Thin Films on Silicon by Rapid Expansion of Supercritical Solutions (RESS) Using Carbon Dioxide

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