&lt;b&gt;&lt;i&gt;In vitro&lt;/i&gt; evaluation of antioxidant activity of methanolic extracts obtained from seaweeds endemic to the coast of Ceará, Brazil

Lima, Rebeca Larangeira de; Pires-Cavalcante, Kelma Maria dos Santos; Alencar, Daniel Barroso de; Viana, Francisco Arnaldo; Sampaio, Alexandre Holanda; Saker-Sampaio, Silvana

doi:10.4025/actascitechnol.v38i2.27275

Cited by 10 publications

(5 citation statements)

References 39 publications

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“…Hence, natural antioxidants constitute an interesting alternative for synthetic ones. Free radical scavenging activities are attributed to several plant, algal, and fungal polysaccharides (Lima et al., 2016; Zhao et al., 2015). In our study, the antioxidant potential of LmPS crude polysaccharides was evaluated in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective effects of novel heteropolysaccharide isolated from Lobularia maritima on CCl4‐induced liver injury in rats

Hsouna

Hfaiedh

Slima

et al. 2022

Food Science & Nutrition

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The aim of the present study was to investigate the extraction and the characterization of a novel heteropolysaccharide from Tunisian halophyte Lobularia maritima (LmPS). We were also interested in its antioxidant, anti‐inflammatory, and hepatoprotective effects on carbon tetrachloride (CCl4)‐induced liver injury in rats. LmPS physicochemical properties were evaluated by thin‐layer chromatography (TLC), high‐performance liquid chromatography (HPLC), thermogravimetric analysis (TGA), and UV absorption. According to TLC and HPLC results, LmPS was a heteropolysaccharide composed of glucose, galactose, and xylose. Its molecular weight was 130.62 kDa. This heteropolysaccharide was characterized by a significant antioxidant potential and was efficient against oxidative stress and CCL4‐induced hepatotoxicity in rat Wistar models (n = 8) treated with a single dose of LmPS 250 mg/kg of body weight. This was evidenced by a significant increase in serum marker enzymes specially aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH). The cytokines released after stimulation of rats with LmPS showed high anti‐inflammatory profiles with an increased rate of interleukine‐10 (IL‐10) with 0.03 pg/mL compared to animals treated only with CCl4. On the contrary, we noticed a decrease of the other cytokines (tumor necrosis factor α: TNF‐α, interleukine‐6: IL‐6, transforming growth factor beta 1: TGF‐β1) with average concentration values of <0.2, 0.1, and 0.04 pg/mL, respectively. Besides, histopathological examinations revealed that CCl4 causes acute liver damage, characterized by extensive hepatocellular necrosis, vacuolization, and inflammatory cell infiltration, as well as DNA fragmentation. LmPS administration at a dose of 250 mg/kg resulted in a significant hepatoprotection, evidenced by a reduction of CCl4‐induced oxidative damage for all tested markers. These findings eagerly confirmed that LmPS was effective in the protection against CCl4‐induced hepatotoxicity and genotoxicity. It, therefore, suggested a potential therapeutic use of this polysaccharide as an alternative medicine for patients with acute liver diseases.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective effects of novel heteropolysaccharide isolated from Lobularia maritima on CCl4‐induced liver injury in rats

Hsouna

Hfaiedh

Slima

et al. 2022

Food Science & Nutrition

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“…Marine algae are valuable sources of bioactive natural products including antioxidants, antitumor agents, and antibacterial agents [20,21]. In recent years, with the continuous development and utilization of marine resources, many polysaccharides with antioxidant activity have been discovered from algae such as brown, green, and red [22].…”

Section: Algal Polysaccharidesmentioning

confidence: 99%

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

et al. 2019

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Marine-derived antioxidant polysaccharides have aroused extensive attention because of their potential nutritional and therapeutic benefits. However, the comprehensive comparison of identified marine-derived antioxidant polysaccharides is still inaccessible, which would facilitate the discovery of more efficient antioxidants from marine organisms. Thus, this review summarizes the sources, chemical composition, structural characteristics, and antioxidant capacity of marine antioxidant polysaccharides, as well as their protective in vivo effects mediated by antioxidative stress reported in the last few years (2013–2019), and especially highlights the dominant role of marine algae as antioxidant polysaccharide source. In addition, the relationships between the chemical composition and structural characteristics of marine antioxidant polysaccharides with their antioxidant capacity were also discussed. The antioxidant activity was found to be determined by multiple factors, including molecular weight, monosaccharide composition, sulfate position and its degree.

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“…An excessive amount of reactive oxygen species may result in lipid peroxidation, which change the structure of body biomolecules, causing cellular disorders, premature aging, mutations or cell death. Different researches have demonstrated seaweed antioxidant capacity in vitro, attributed to the presence of new antioxidant compounds like carotenoids, certain polysaccharides, and polyphenols, which show scavenger activity, being able to neutralize those reactive oxygen species through their own oxidation, since their affinity to those oxidative compounds is very high [56,68,80,81,82,83,84,85].…”

Section: General Current Seaweed Industrial Applicationsmentioning

confidence: 99%

The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value

et al. 2019

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Two thirds of the world is covered by oceans, whose upper layer is inhabited by algae. This means that there is a large extension to obtain these photoautotrophic organisms. Algae have undergone a boom in recent years, with consequent discoveries and advances in this field. Algae are not only of high ecological value but also of great economic importance. Possible applications of algae are very diverse and include anti-biofilm activity, production of biofuels, bioremediation, as fertilizer, as fish feed, as food or food ingredients, in pharmacology (since they show antioxidant or contraceptive activities), in cosmeceutical formulation, and in such other applications as filters or for obtaining minerals. In this context, algae as food can be of help to maintain or even improve human health, and there is a growing interest in new products called functional foods, which can promote such a healthy state. Therefore, in this search, one of the main areas of research is the extraction and characterization of new natural ingredients with biological activity (e.g., prebiotic and antioxidant) that can contribute to consumers’ well-being. The present review shows the results of a bibliographic survey on the chemical composition of macroalgae, together with a critical discussion about their potential as natural sources of new functional ingredients.

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<b><i>In vitro</i> evaluation of antioxidant activity of methanolic extracts obtained from seaweeds endemic to the coast of Ceará, Brazil

Cited by 10 publications

References 39 publications

Antioxidant and hepatoprotective effects of novel heteropolysaccharide isolated from Lobularia maritima on CCl4‐induced liver injury in rats

Antioxidant and hepatoprotective effects of novel heteropolysaccharide isolated from Lobularia maritima on CCl4‐induced liver injury in rats

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value

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