The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

Zhong, Qi-Wu; Wei, Bin; Wang, Sijia; Ke, Songze; Chen, Jianwei; Zhang, Huawei

doi:10.3390/md17120674

Cited by 159 publications

(115 citation statements)

References 171 publications

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“…The structural features like the composition of monomers, sulfate level and its position in the sugar moiety, chain length, molecular weight etc. of the polymer make them ideal materials for various biomedical applications [7,8]. Cholesterol and lipid-controlling properties of carrageenan have been demonstrated in a clinical trial and found significant reduction in the serum cholesterol and triglyceride levels [9].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

et al. 2020

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In recent times, there has been a growing interest in the exploration of antioxidants and global trend toward the usage of seaweeds in the food industries. The low molecular weight up to 14 kDa sulfated polysaccharides of seaweeds (Portieria hornemannii, Spyridia hypnoides, Asparagopsis taxiformis, Centroceras clavulatum and Padina pavonica) were evaluated for in vitro antioxidant activities and cytotoxic assay using HeLa cell line and also characterized by FTIR. The high yield (7.74% alga dry wt.) of sulfated polysaccharide was observed in P. hornemannii followed by S. hypnoides (0.69%), C. clavulaum (0.55%) and A. taxiformis (0.17%). In the brown seaweed P. pavonica, the sulfated polysaccharide yield was 2.07%. High amount of sulfate was recorded in the polysaccharide of A. taxiformis followed by C. clavulaum, P. pavonica, S. hypnoides and P. hornemannii as indicative for bioactivity. The FTIR spectroscopic analysis supports the sulfated polysaccharides of S. hypnoides, C. clavulatum and A. taxiformis are similar to agar polymer whereas the spectral characteristics of P. hornemannii have similarities to carrageenan. The higher DPPH activity and reducing power were recorded in the polysaccharide of brown seaweed P. pavonica than the red seaweeds as follows: DPPH activities: S. hypnoides > A. taxiformis > C. clavulatum > P. hornimanii; Reducing power: A. taxiformis > P. hornimanii > S. hypnoides > C. clavulatum. The polysaccharide fractions contain up to 14 kDa from red seaweeds P. hornemannii and S. hypnoides followed by brown seaweed P. pavonica exhibit cytotoxic activity in HeLa cancer cell line (and are similar to structural properties of carrageenan extracted from P. hornemannii). The low molecular weight agar like polymer of S. hypnoides and alginate like brown seaweed P. pavonica showing better in vitro antioxidant activities that are capable of exhibiting cytotoxicity against HeLa cell line can be taken up further in-depth investigation for nutraceutical study.

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Section: Introductionmentioning

confidence: 99%

“…Carrageenan is well known in controlling the inflammation and a complete review on carrageenan biological activities was reported [10,11]. Recently, Zhong et al [8] reviewed the cytotoxic and antioxidant activity in various seaweeds polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

et al. 2020

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“…In addition, it is reported that natural products could have a xenobiotic effect, and the intestinal ecosystem has been shown to be responsible for xenobiotic biotransformation [40]. Recent studies displayed that polysaccharides could reduce oxidative stress by regulating gut microbiota composition or activating gastrointestinal immune cells, and could be degraded in gastrointestinal tract, thus they could pass through the intestinal epithelial cells and enter the blood circulation [6]. As for the xenobiotic effect of PEP and its interaction with microbiota pattern should be given more attention and exploring further.…”

Section: Discussionmentioning

confidence: 99%

“…Since polysaccharide from natural materials is one of the most important compounds with various biological activities. For example, polysaccharides from marine sources are considered to possess antioxidant [6], antitumor, anti-inflammatory, anticoagulant, hypoglycemic, hypolipidemic effect and immunomodulatory ability [7,8]. Several natural marine polysaccharides display antioxidant and hypolipidemic effects, such as polysaccharides from Enteromorpha prolifera [9], Ulva pertusa [10] and sea cucumber [3,11,12], implying that polysaccharides might be developed as novel potential hypolipidemic agents.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Jiang

Lin

et al. 2020

Marine Drugs

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The aims of this study were to investigate the antioxidant, hypolipidemic and hepatic protective effects of Phascolosoma esculenta polysaccharides (PEP). PEP was prepared from Phascolosoma esculenta by enzyme hydrolysis and its characterization was analyzed. The antioxidant activities of PEP were evaluated by the assays of scavenging 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radicals and chelating ferrous ion in vitro. It showed that PEP could scavenge radicals effectively and had favorable antioxidant activities. In the meantime, the hypolipidemic effect of PEP was investigated in vivo by using mice model fed with high-fat diet with or without PEP treatment. Compared with the hyperlipidemic mice without treatment, the serum levels of total cholesterol (TC) (30.1–35.7%, p < 0.01), triglyceride (TG) (24.5–50.8%, p < 0.01 or p < 0.05), low-density lipoprotein cholesterol (LDL-C) (49.6–56.8%, p < 0.01) and liver levels of TC (21.0–28.4%, p < 0.01), TG (23.8–37.0%, p < 0.01) decreased significantly, whereas serum high-density lipoprotein cholesterol (HDL-C) (47.7–59.9%, p < 0.01 or p < 0.05) increased significantly after treatment with different dosage of PEP (0.2, 0.4 and 0.8 g per kg body weight, respectively). In addition, superoxide dismutase (SOD) (10.2–22.2% and 18.8–26.9%, p < 0.05), glutathione peroxidase (GSH-Px) (11.9–15.4% and 26.6–30.4%, p < 0.05) activities in serum and liver enhanced markedly while aspartate aminotransferase (AST) (18.7–29.6% and 42.4–58.0%, p < 0.05), alanine transaminase (ALT) (42.7–46.0% and 31.2–42.2%, p < 0.05) activities, as well as the levels of malondialdehyde (MDA) (15.9–24.4% and 15.0–16.8%, p < 0.01 or p < 0.05) in serum and liver reduced markedly. Moreover, the histopathological observation of livers indicated that PEP could attenuate liver cell injury. The animal experimental results demonstrated that PEP exerted hypolipidemic and hepatoprotective roles in hyperlipidemic mice. In summary, our results above suggest that PEP might be a potential natural antioxidant and utilized as a therapeutic candidate for hyperlipidemia.

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“…Free radicals, which are produced in the body as byproducts of normal metabolism and other environmental factors, can damage proteins, nucleic acids, as well as carbohydrates and are believed to contribute to premature aging and dementia [32][33][34]. Antioxidants can scavenge these free radicals to reduce cellular damage and prevent different diseases.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

Zhang

Tan

et al. 2020

Marine Drugs

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Chitosan is an active biopolymer, and the combination of it with other active groups can be a valuable method to improve the potential application of the resultant derivatives in food, cosmetics, packaging materials, and other industries. In this paper, a series of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives were synthesized. The combination of chitosan with ureidopyridinium group and quaternary ammonium group made it achieve developed water solubility and biological properties. The structures of chitosan and chitosan derivatives were confirmed by FTIR, 1H NMR spectra, and elemental analysis. The prepared chitosan derivatives were evaluated for antioxidant property by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical scavenging ability, and superoxide radical scavenging ability. The results revealed that the synthesized chitosan derivatives exhibited improved antioxidant activity compared with chitosan. The chitosan derivatives were also investigated for antifungal activity against Phomopsis asparagus as well as Botrytis cinerea, and they showed a significant inhibitory effect on the selected phytopathogen. Meanwhile, CCK-8 assay was used to test the cytotoxicity of chitosan derivatives, and the results showed that most derivatives had low toxicity. These data suggested to develop analogs of chitosan derivatives containing ureidopyridinium group and quaternary ammonium group, which will provide a new kind of promising biomaterials having decreased cytotoxicity as well as excellent antioxidant and antimicrobial activity.

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The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

Cited by 159 publications

References 171 publications

Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

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