&lt;b&gt;Evaluation of internal and external markers for estimating dry matter intake and digestibility in cattle&lt;/b&gt;

Velasquez, Alejandro Vargas

doi:10.11606/t.10.2017.tde-17052017-152938

Cited by 1 publication

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“…Nonetheless, ABL2 is a potential candidate gene for HW, harboring rs42843320. ABL2 influenced feed intake in cattle and backfat thickness in pigs [106,107]. In addition, ABL2 is involved in innate immune response processes through cell proliferation, migration and differentiation (according to its functional annotation in the DAVID database).…”

Section: Heart Girth and Hip Widthmentioning

confidence: 99%

A multi-breed GWAS for morphometric traits in four Beninese indigenous cattle breeds reveals loci associated with conformation, carcass and adaptive traits

et al. 2020

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Background Specific adaptive features including disease resistance and growth abilities in harsh environments are attributed to indigenous cattle breeds of Benin, but these breeds are endangered due to crossbreeding. So far, there is a lack of systematic trait recording, being the basis for breed characterizations, and for structured breeding program designs aiming on conservation. Bridging this gap, own phenotyping for morphological traits considered measurements for height at withers (HAW), sacrum height (SH), heart girth (HG), hip width (HW), body length (BL) and ear length (EL), including 449 cattle from the four indigenous Benin breeds Lagune, Somba, Borgou and Pabli. In order to utilize recent genomic tools for breed characterizations and genetic evaluations, phenotypes for novel traits were merged with high-density SNP marker data. Multi-breed genetic parameter estimations and genome-wide association studies (GWAS) for the six morphometric traits were carried out. Continuatively, we aimed on inferring genomic regions and functional loci potentially associated with conformation, carcass and adaptive traits. Results SNP-based heritability estimates for the morphometric traits ranged between 0.46 ± 0.14 (HG) and 0.74 ± 0.13 (HW). Phenotypic and genetic correlations ranged from 0.25 ± 0.05 (HW-BL) to 0.89 ± 0.01 (HAW-SH), and from 0.14 ± 0.10 (HW-BL) to 0.85 ± 0.02 (HAW-SH), respectively. Three genome-wide and 25 chromosome-wide significant SNP positioned on different chromosomes were detected, located in very close chromosomal distance (±25 kb) to 15 genes (or located within the genes). The genes PIK3R6 and PIK3R1 showed direct functional associations with height and body size. We inferred the potential candidate genes VEPH1, CNTNAP5, GYPC for conformation, growth and carcass traits including body weight and body fat deposition. According to their functional annotations, detected potential candidate genes were associated with stress or immune response (genes PTAFR, PBRM1, ADAMTS12) and with feed efficiency (genes MEGF11 SLC16A4, CCDC117). Conclusions Accurate measurements contributed to large SNP heritabilities for some morphological traits, even for a small mixed-breed sample size. Multi-breed GWAS detected different loci associated with conformation or carcass traits. The identified potential candidate genes for immune response or feed efficiency indicators reflect the evolutionary development and adaptability features of the breeds.

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Section: Heart Girth and Hip Widthmentioning

confidence: 99%

A multi-breed GWAS for morphometric traits in four Beninese indigenous cattle breeds reveals loci associated with conformation, carcass and adaptive traits

et al. 2020

View full text Add to dashboard Cite

show abstract

<b>Evaluation of internal and external markers for estimating dry matter intake and digestibility in cattle</b>

Abstract: VELASQUEZ, A.V. Evaluation of internal and external markers for estimating dry matter intake and digestibility in cattle. [Avaliação de marcadores internos e externos para estimar o consumo e a digestibilidade da matéria seca em bovinos]. 2017. 87 f. Tese (Doutorado em

Cited by 1 publication

References 45 publications

A multi-breed GWAS for morphometric traits in four Beninese indigenous cattle breeds reveals loci associated with conformation, carcass and adaptive traits

A multi-breed GWAS for morphometric traits in four Beninese indigenous cattle breeds reveals loci associated with conformation, carcass and adaptive traits

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