Abstract:The effects of acute hypoxia (9% O2) on the levels of erythroycte 2,3-diphosphoglycerate (2,3-DPG) and hepatic adenine nucleotides were investigated. Measurements were made from both fed and starved mice. 1) Exposure of fed mice to 9% O2 rapidly increased erythrocyte 2,3-DPG, which is considered to be a reflection of metabolic adaptation to hypoxia. The liver adenylate pool remained unchanged for one day under hypoxic states, and a marked reduction in the hepatic adenylates occurred after 3 days. 2) When mice … Show more
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