LSD and dopamine receptors (reply)

Pieri, L.; Pieri, Margherita; Haefely, W.

doi:10.1038/257070a0

Nature

1975

DOI: 10.1038/257070a0

|View full text |Cite

LSD and dopamine receptors (reply)

L. Pieri

Margherita Pieri

W. Haefely

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1976

1985

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…which are considered to act as direct 5-HT receptor agonists in the CNS, like Iysergic acid diethylamide (LSD) or lisuride, are also known to inhibit 5•HT turnover(4, 31,39) as well as firing of raphe neurons(3,39,42). These observations are in agreement with the assumption of receptor-mediated feedback; however, they are not neo cessarily supportive evidence for a neuronal feedback loop, since both compounds have direct depressant effects on raphe neurons (see blow).The effect of 5-HT receptor antagonists on 5-HT turnover in rodent brain is not unequivocal.…”

mentioning

confidence: 99%

Receptor-mediated Regulation of 5-Hydroxytryptamine Metabolism:Current Knowledge and Open Questions

Kehr¹

1985

Pharmacopsychiatry

View full text Add to dashboard Cite

As demonstrated for the catecholamine system several receptor-mediated mechanisms appear to be involved in the regulation of serotonergic transmission, though regulatory processes of serotonergic transmission are less well investigated as compared with the catecholamine system. One of the main homeostatic mechanisms appears to be neuronal feedback mediated by postsynaptic 5-HT receptors. The constituents of the neuronal feedback loop are unknown at present. In addition to neuronal feedback, an autoreceptor-mediated feedback appears to exist. According to their localization, 5-HT autoreceptors can be subdivided into somatodendritic and presynaptic autoreceptors. Stimulation of somatodendritic 5-HT receptors leads to inhibition of the firing rate, and stimulation of presynaptic autoreceptors in vitro to inhibition of impulse-induced release of 5-HT. Further to 5-HT receptors, other transmitter receptors appear to exist on presynaptic nerve terminals which may either inhibit or facilitate 5-HT release. The physiological significance of all these presynaptic receptors remains to be shown. The evaluation of feedback mechanisms controlling 5-HT neurons is hampered by the fact that no selective central 5-HT antagonists are available at present. There is an urgent need for selective receptor antagonists for 5-HT autoreceptors as well as postsynaptic receptors. Binding studies have revealed at least two subtypes of 5-HT receptors, 5-HT1 and 5-HT2 receptors. Selective 5-HT1 and 5-HT2 agonists and antagonists are needed in order to characterize these receptors subtypes and to find their functional correlates.

show abstract

mentioning

confidence: 99%

Receptor-mediated Regulation of 5-Hydroxytryptamine Metabolism:Current Knowledge and Open Questions

Kehr¹

1985

Pharmacopsychiatry

View full text Add to dashboard Cite

show abstract

Turning in circles: The neuropharmacology of rotation

1976

View full text Add to dashboard Cite

Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD

Sovilla

Magistretti

Schorderet

1979

Progress in Neuro-Psychopharmacology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

LSD and dopamine receptors (reply)

Cited by 3 publications

References 3 publications

Receptor-mediated Regulation of 5-Hydroxytryptamine Metabolism:Current Knowledge and Open Questions

Receptor-mediated Regulation of 5-Hydroxytryptamine Metabolism:Current Knowledge and Open Questions

Turning in circles: The neuropharmacology of rotation

Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD

Contact Info

Product

Resources

About