Turning in circles: The neuropharmacology of rotation

Glick, Stanley D.; Jerussi, Thomas P.; Fleisher, Lloyd N.

doi:10.1016/0024-3205(76)90405-7

Cited by 283 publications

(26 citation statements)

References 45 publications

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“…If this is, indeed, the case the increased circling shown by morphine abstinent rats is consistent with the report by Iversen & Joyce (1978) that apomorphine-induced locomotor activity is increased when rats are tested in withdrawal from morphine. Iwamoto et al (1976b) reported that morphinedependent rats with unilateral lesions of the zona compacta of the substantia nigra showed contralateral rotation during precipitated abstinence and our discrepant observations may reflect differences in the site and size of the lesion (Anden et al, 1966;Glick et al, 1976) as well as procedural variations. Laschka et al (1976) inactivated rats' corpora striata on one side with KC1 and then recorded circling behaviour; in non-tolerant rats small subcutaneous doses of apomorphine (0.05 mg/kg) had no effect and large doses (3.0 mg/kg) produced marked ipsilateral circling.…”

Section: Discussioncontrasting

confidence: 44%

Morphine Dependence and Dopaminergic Activity: Tests of Circling Responses in Rats With Unilateral Nigral Lesions

Halliwell

Kumar²

1980

British J Pharmacology

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I Rats with unilateral electrolytic lesions involving both parts of the substantia nigra show doserelated, ipsilateral circling responses to apomorphine which are stable over time. 2 In non-tolerant rats, morphine (up to 10 mg/kg) does not elicit any circling behaviour but as tolerance develops to morphine, initially 10 mg/kg daily and then 100 mg/kg daily for about 4 months, the rats show a progressive tendency to walk more towards the side of the lesion. This behaviour is qualitatively different from apomorphine-induced circling. 3 When apomorphine (0 to 1.0 mg/kg) and morphine (10 or 100 mg/kg) are tested together, the total amounts of 'circling' are increased in an additive manner. However, after 22 h withdrawal from morphine there is a more marked increase in apomorphine-induced circling which is related to the level of dependence. 4 It is suggested that the sensitivity of striatal dopamine receptors is not altered by morphine dependence and that the increased response to apomorphine in abstinence probably reflects changes in the modulating actions of other neurotransmitter systems in the striatum.

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Section: Discussioncontrasting

confidence: 44%

Morphine Dependence and Dopaminergic Activity: Tests of Circling Responses in Rats With Unilateral Nigral Lesions

Halliwell

Kumar²

1980

British J Pharmacology

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“…Finally, intensity and direction of apomorphine-induced turning appear to depend on the extent of striatal damage. The animals turned contralaterally when there were enough of hypersensitive dopaminergic receptors left in the damaged neostriatum and ipsilaterally when the loss of striatal tissue was too se'vere (Glick, Jerussi, & Fleisher, 1976).…”

Section: Discussionmentioning

confidence: 99%

Handedness in rats: Blockade of reaching behavior by unilateral 6-OHDA injections into substantia nigra and caudate nucleus

Siegfried

Bureš

1980

Psychobiology

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“…One important movement characteristic, associated with a vast number of cognitive functions arguably mediated by one or the other cerebral hemisphere is body rotation, or turning bias. Turning bias has been extensively studied in animal species, from amphibian (Rogers, 2002) to fish (Vallortigara & Bisazza, 2002), and especially in rodents (S. Glick, Jerussi, & Fleisher, 1976). The model of the "circling rat" (S. D. Glick & Ross, 1981) has helped to establish dopaminergic imbalances underlying asymmetric manifestations of Parkinson's disease.…”

Section: Introductionmentioning

confidence: 99%

Measurement of human rotation behavior for psychological and neuropsychological investigations

et al. 2015

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The investigation of rotation behavior in human beings enjoys a longstanding and enduring interest in laterality research. While in animal studies the issue of accurately measuring the number of rotations has been solved and is widely applied in practice, it is still challenging to assess the rotation behavior of humans in daily life. We propose a robust method to assess human rotation behavior based on recordings from a miniature inertial measurement unit that can be worn unobtrusively on a belt. We investigate the effect of different combinations of low-cost sensors-including accelerometers, gyroscopes, and magnetometers-on rotation measurement accuracy, propose a simple calibration procedure, and validate the method on data from a predefined path through and around buildings. Results suggest that a rotation estimation based on the fusion of accelerometer, gyroscope, and magnetometer measurements outperforms methods based solely on earth magnetic field measurements, as proposed in previous studies, by a drop in error rate of up to 32 %. We further show that magnetometer signals do not significantly contribute to measurement accuracy in short-term measurements, and could thus be omitted for improved robustness in environments with magnetic field disturbances. Results also suggest that our simple calibration procedure can compete with more complex approaches and reduce the error rate of the proposed algorithm by up to 38 %. The investigation of rotation behavior in human beings enjoys a longstanding and enduring interest in laterality research. While, in animal studies, the issue of accurately measuring the number of rotations has been solved and is widely applied in practice, it is still challenging to assess the rotation behavior of humans in daily life. We propose a robust method to assess human rotation behavior based on recordings from a miniature inertial measurement unit that can be worn unobtrusively on a belt. We investigate the effect of different combinations of low-cost sensors -including accelerometers, gyroscopes and magnetometers -on rotation measurement accuracy, propose a simple calibration procedure, and validate the method on data from a predefined path through and around buildings. Results suggest that a rotation estimation based on the fusion of accelerometer, gyroscope and magnetometer measurements outperforms methods based solely on earth magnetic field measurements, as proposed in previous studies, by a drop in error rate of up to 32%. We further show that magnetometer signals do not significantly contribute to measurement accuracy in short-term measurements, and could thus be omitted for improved robustness in environments with magnetic field disturbances. Results also suggest that our simple calibration procedure can compete with more complex approaches and reduces the error rate of the proposed algorithm by up to 38%.

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Turning in circles: The neuropharmacology of rotation

Cited by 283 publications

References 45 publications

Morphine Dependence and Dopaminergic Activity: Tests of Circling Responses in Rats With Unilateral Nigral Lesions

Morphine Dependence and Dopaminergic Activity: Tests of Circling Responses in Rats With Unilateral Nigral Lesions

Handedness in rats: Blockade of reaching behavior by unilateral 6-OHDA injections into substantia nigra and caudate nucleus

Measurement of human rotation behavior for psychological and neuropsychological investigations

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