LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation

Morimoto, Keiko; Baba, Yoshifumi; Shinohara, Hisaaki; Kang, Sujin; Nojima, Satoshi; Kimura, Tetsuya; Ito, Daisuke; Yoshida, Yūji; Maeda, Yohei; Sarashina-Kida, Hana; Nishide, Masayuki; Hosokawa, Takashi; Kato, Yasuhiro; Hayama, Yoshitomo; Kinehara, Yuhei; Okuno, Tatsusada; Takamatsu, Hyota; Hirano, Tôru; Shima, Yoshihito; Narazaki, Masashi; Kurosaki, Tomohiro; Toyofuku, Toshihiko; Kumanogoh, Atsushi

doi:10.1038/srep25738

Cited by 24 publications

(25 citation statements)

References 59 publications

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“…LRRK1 has been reported to regulate the proliferation of B-cells [19]. To confirm that LINC00511 promoted T-ALL development by regulating LRRK1, rescue assays were carried out.…”

Section: Linc00511 Exacerbated T-all By Up-regulating Lrrk1mentioning

confidence: 99%

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

Guo

Geng³

et al. 2020

Bioscience Reports

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T-cell acute lymphoblastic leukemia (T-ALL) is a malignant disease arising from the abnormal proliferation of T lymphocyte in marrow. Long non-coding RNAs (lncRNAs) are one kind of non-coding RNAs (ncRNAs), which were reported to modulate the initiation or progression of diverse cancers. However, the role of LINC00511 in T-ALL was unknown. To figure out the function and mechanism of LINC00511 in T-ALL, a series of experiments were carried out. Based on the experimental results, we discovered that LINC00511 boosted cell proliferation and invasion, but hindered cell apoptosis in T-ALL cells. Besides, based on bio-informatics tool, miR-195-5p was selected for further exploration. Then, miR-195-5p was validated to bind with LINC00511. Hereafter, LRRK1 was testified to serve as a target gene of miR-195-5p. At last, rescue assays suggested that LRRK1 overexpression restored sh-LINC00511#1-mediated effects on cell proliferation and apoptosis. All in all, LINC00511 exacerbated T-ALL progression via miR-195-5p/LRRK1 axis, implying a potential therapeutic clue for the patients with T-ALL.

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“…LRRK1 has been reported to regulate the proliferation of B-cells [19]. To confirm that LINC00511 promoted T-ALL development by regulating LRRK1, rescue assays were carried out.…”

Section: Linc00511 Exacerbated T-all By Up-regulating Lrrk1mentioning

confidence: 99%

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

Guo

Geng³

et al. 2020

Bioscience Reports

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“…[11] LRRK1 has been associated with numerous distinct cellular mechanisms, which include EGFR trafficking, [12] mitotic spindle orientation, [13] and humoral immunity. [14] LRRK2 has been implicated in a diverse range of cellular processes, including macroautophagy, cytoskeletal dynamics, and mitochondrial function. [15] Finally MASL1, the least studied of the human ROCO proteins, has functional connections to macrophage polarization [16,17] and erythropoiesis.…”

Section: Introductionmentioning

confidence: 99%

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Tomkins

Dihanich²,

Beilina

et al. 2018

Proteomics

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Signal transduction cascades governed by kinases and GTPases are a critical component of the command and control of cellular processes, with the precise outcome partly determined by direct protein–protein interactions (PPIs). Here, we use the human ROCO proteins as a model for investigating PPI signaling events—taking advantage of the unique dual kinase/GTPase activities and scaffolding properties of these multidomain proteins. PPI networks are reported that encompass the human ROCO proteins, developed using two complementary approaches. First, using the recently developed weighted PPI network analysis (WPPINA) pipeline, a confidence-weighted overview of validated ROCO protein interactors is obtained from peer-reviewed literature. Second, novel ROCO PPIs are assessed experimentally via protein microarray screens. The networks derived from these orthologous approaches are compared to identify common elements within the ROCO protein interactome; functional enrichment analysis of this common core of the network identified stress response and cell projection organization as shared functions within this protein family. Despite the presence of these commonalities, the results suggest that many unique interactors and therefore some specialized cellular roles have evolved for different members of the ROCO proteins. Overall, this multi-approach strategy to increase the resolution of protein interaction networks represents a prototype for the utility of PPI data integration in understanding signaling biology.

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“…A controversy may arise out of the avidity augmentation and increase of the Hill coefficient of IgM produced by G1 after the twice administrations compared with that at the single administration (Figure a ) . There are several reports that enhanced stimulations to B cell receptors induced the positive selection of the B1a cell without any genetic mutation . As previously reported, B1a cells were firstly stimulated by G1 in the peritoneal cavity and migrated to spleen accompanied by differentiation into plasma cells .…”

Section: Resultsmentioning

confidence: 64%

“…There are several reports that enhanced stimulations to B cell receptors induced the positive selection of the B1a cell without any genetic mutation. [50][51][52][53] As previously reported, B1a cells were firstly stimulated by G1 in the peritoneal Figure 7. Near-infrared fluorescence images of naive mice at 5 min, 1, 3, 6, and 24 h after single administration of each indocyanine green-labeled selfassemblies (5 mg/kg).…”

Section: Elisa Competition Binding Assaymentioning

confidence: 74%

Modulation of immunogenicity of poly(sarcosine) displayed on various nanoparticle surfaces due to different physical properties

Kim

Hara

Watabe

et al. 2017

Journal of Peptide Science

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Poly(sarcosine) displayed on polymeric micelle is reported to trigger a T cell-independent type2 reaction with B1a cells in the mice to produce IgM and IgG3 antibodies. In addition to polymeric micelle, three kinds of vesicles displaying poly(sarcosine) on surface were prepared here to evaluate the amounts and avidities of IgM and IgG3, which were produced in mice, to correlate them with physical properties of the molecular assemblies. The largest amount of IgM was produced after twice administrations of a polymeric micelle of 35 nm diameter (G1). On the other hand, the production amount of IgG3 became the largest after twice administrations of G3 (vesicle of 229 nm diameter) or G4 (vesicle of 85 nm diameter). The augmented avidity of IgG3 after the twice administrations compared with that at the single administration was the highest with G3. These differences in immune responses are discussed in terms of surface density of poly(sarcosine) chains, nanoparticle size, hydrophobic component of poly(L-lactic acid) or (Leu- or Val-Aib) , and membrane elasticity of the nanoparticles. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

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LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation

Cited by 24 publications

References 59 publications

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Modulation of immunogenicity of poly(sarcosine) displayed on various nanoparticle surfaces due to different physical properties

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