LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients

Kang, Eun Seok; Park, Se Eun; Han, Seung Jin; Kim, So Hun; Nam, Chung Mo; Ahn, Chul Woo; Soo, Bong; Kim, Kyung Sub

doi:10.1016/j.ymgme.2008.06.011

Cited by 28 publications

(15 citation statements)

References 20 publications

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“…It is significant that LPIN1 genotype is associated with several individual features of the metabolic syndrome, as well as with an overall "metabolic syndrome factor score" (61), and may reflect the roles that lipin-1 has in several tissues that influence metabolic homeostasis. Furthermore, a specific LPIN1 polymorphism is associated with the response of type 2 diabetics to thiazolidinedione treatment (63).…”

Section: Genetic Variation In Lipin Genes and Human Diseasementioning

confidence: 99%

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

Reue

Brindley

2008

Journal of Lipid Research

172

178

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Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine. PAP1 activity in mammals is determined by the lipin family of proteins, lipin-1, lipin-2, and lipin-3, which each have distinct tissue expression patterns and appear to have unique physiological functions. In addition to its role in glycerolipid synthesis, lipin-1 also operates as a transcriptional coactivator, working in collaboration with known nuclear receptors and coactivators to modulate lipid metabolism gene expression. The requirement for different lipin activities in vivo is highlighted by the occurrence of lipodystrophy, insulin resistance, and neuropathy in a lipin-1-deficient mutant mouse strain. In humans, variations in lipin-1 expression levels and gene polymorphisms are associated with insulin sensitivity, metabolic rate, hypertension, and risk for the metabolic syndrome. Furthermore, critical mutations in lipin-2 result in the development of an inflammatory disorder in human patients. A key goal of future studies will be to further elucidate the specific roles and modes of regulation of each of the three lipin proteins in key metabolic processes, including triglyceride and phospholipid synthesis, fatty acid metabolism, and insulin sensitivity.-Reue, K. and D. N. Brindley. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. J. Lipid Res. 2008Res. . 49: 2493Res. -2503

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Section: Genetic Variation In Lipin Genes and Human Diseasementioning

confidence: 99%

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

Reue

Brindley

2008

Journal of Lipid Research

172

178

View full text Add to dashboard Cite

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Section: Lipin-1 Gene Mutations and Polymorphisms Associated With Dismentioning

confidence: 99%

“…Among these are insulin and/or glucose levels (17,34,35), resting metabolic rate (34), and systolic blood pressure (36,37). LPIN1 polymorphisms that are associated with response of type 2 diabetic patients to rosiglitazone have also been reported (36). One particularly notable LPIN1 polymorphism causes an amino acid substitution within the C-LIP domain and is associated with statin-induced myopathy (33), an unfortunate side effect experienced by some of individuals who take statin drugs to treat hypercholesterolemia [reviewed in (38)].…”

Section: Lipin-1 Gene Mutations and Polymorphisms Associated With Dismentioning

confidence: 99%

Lipin proteins and metabolic homeostasis

Reue

Dwyer

2009

Journal of Lipid Research

108

102

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The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders. Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins.-Reue, K., and J. R. Dwyer. Lipin proteins and metabolic homeostasis. J. Lipid Res. 2009. 50: S109-S114.Supplementary key words lipodystrophy • obesity • triglyceride • phosphatidate phosphatase • insulin resistance

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“…188 In humans, overexpression of PLIN 2 decreases gene expression of several PPARa target genes and facilitates intramyocellular lipid. 148 In pigs, PLIN2 gene expression was associated with IM deposition.…”

mentioning

confidence: 99%