Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

Abstract

One of the most common post-operative complications of tooth extraction is pain. Oral analgesics, namely loxoprofen sodium and diclofenac potassium, are often prescribed; however, the efficacy of these drugs irrespective of gender and type of extraction has not been tested. Therefore, this study aimed to compare the efficacy of these two drugs in post-dental extraction pain relief among male and female patients in cases of simple and surgical tooth extraction. A single-center, triple-blind, randomized clinical trial was conducted among 100 male and female patients who underwent tooth extraction at Taibah University Dental College and Hospital in Al-Madinah, Saudi Arabia. The patients reported their pain post-operatively after 6 hours and every 12 h for 3 days using the Verbal Descriptor Scale (e.g., “no pain”, “mild pain”). Descriptive statistics and chi-square tests were run to analyze the data. An equal number of patients received either the drug loxoprofen sodium or diclofenac potassium and completed the study follow-up. Patients allocated to the diclofenac potassium drug group after 36 h were statistically significantly in their reporting of “no pain” and “mild pain” compared to patients allocated to the loxoprofen sodium group (86% vs. 66%, respectively; p = 0.019), irrespective of gender or type of tooth extraction. However, both groups demonstrated comparable (p > 0.05) post-operative pain relief over the other aforementioned allocated time intervals. In conclusion, the diclofenac potassium group had slightly better control over post-operative pain than the group receiving loxoprofen sodium.

Comparative study on the effects of the inclusion complexes of non-steroidal anti-inflammatory drugs with 2-hydroxypropyl-β-cyclodextrins on dissociation rates and supersaturation

“…This is caused by renal ischemia because DCF is harmful to renal function. 28 DCF has individual advantages and disadvantages similar to other NSAIDs; therefore, this alone does not indicate that the more potent activity of DCF results in more predominant prescriptions than LXP. To accommodate the clinical data of the patients, DCF, LXP, celecoxib, ibuprofen, and other NSAIDs were chosen, considering the performance of the API and its combinations with other medicinal ingredients.…”

Study of the stereospecificity in the biotransformation of the four isomers of loxoprofen sodium in rats by chiral HPLC

“…Loxoprofen sodium (LOX), sodium 2-[4-(2oxocyclopentylmethyl) phenyl] propionate dihydrate, was first developed for marketing as a new NSAID in Japan [10,11]. Due to the higher anti-inflammatory and analgesic effects, as well as the shorter T max after oral administration than other NSAIDs, LOX has rapidly become one of the most popular NSAIDs in Japan [12][13][14][15][16]. As with other profens, for example, ibuprofen, ketoprofen, and naproxen [5,8,9], an optical inversion of (2R)-to (2S)-configuration occurs in the moiety of α-substituted propionic acid after oral administration of racemic LOX [17].…”