Comparative study on the effects of the inclusion complexes of non-steroidal anti-inflammatory drugs with 2-hydroxypropyl-β-cyclodextrins on dissociation rates and supersaturation

Abstract

This result suggests that the ratio deemed appropriate in solid-phase analysis may not necessarily align with it is based on the stability constant in the aqueous solution.

How Does the Powder Mixture of Ibuprofen and Caffeine Attenuate the Solubility of Ibuprofen? Comparative Study for the Xanthine Derivatives to Recognize Their Intermolecular Interactions Using Fourier-Transform Infrared (FTIR) Spectra, Differential Scanning Calorimetry (DSC), and X-ray Powder Diffractometry (XRPD)

“…The diffractograms of pure DCF were consistent with the pattern of polymorph HD2 and transformed into a halo pattern at the T m . 57 The signal heights at 17.7, 23.5, and 27.9°e xhibited different patterns depending on the rising temperature, suggesting that DCF switched its crystalline habits in response to each temperature level. Figure 5e shows the DSC-XRPD diffractograms of the CFN/IBP equimolar mixture, where the diffraction signals of IBP and CFN were not observed at 358 and 420 K, respectively.…”

“…These two signals were assigned to the HD2-form signals of DCF, which differ from the diffractions of the other polymorphs, HD1 and HD3. 57 A previous study used various solvents for recrystallizing DCF to prepare crystals with lower (in 2-propanol) and higher (in acetonitrile) T m than the purchased pure DCF and crystals prepared in diethyl ether, acetone, chloroform, and ethanol. 57 However, the XRPD signals of these crystals were identical to those of the HD2 crystals, suggesting that they did not exhibit new crystalline habits with similar T m values.…”

“…57 A previous study used various solvents for recrystallizing DCF to prepare crystals with lower (in 2-propanol) and higher (in acetonitrile) T m than the purchased pure DCF and crystals prepared in diethyl ether, acetone, chloroform, and ethanol. 57 However, the XRPD signals of these crystals were identical to those of the HD2 crystals, suggesting that they did not exhibit new crystalline habits with similar T m values. Lai et al reported different HD2-polymorphic crystals as DCF1 (T m 454 K) and DCF2 (T m 449 K) on their notation.…”