Lower Uncarboxylated Osteocalcin Concentrations in Children with Prediabetes Is Associated with β-Cell Function

Abstract

These data suggest that the lower uncarboxylated osteocalcin concentrations found in children with prediabetes may be associated with β-cell dysfunction. In addition, our findings between carboxylated osteocalcin and insulin sensitivity suggest that carboxylated osteocalcin plays a role in human glucose homeostasis.

Ameliorated pancreatic β cell dysfunction in type 2 diabetic patients treated with a sodium-glucose cotransporter 2 inhibitor ipragliflozin

“…The disposition index as a product of insulin secretion and sensitivity indices derives its validity from a hyperbolic relationship between these two indices. Although a number of clinical studies demonstrated the validity and usefulness of these indices overseas [8][9][10][11][12][13], it remained unrevealed whether a hyperbolic relationship is similarly observed in a Japanese population. However, in the current study, insulin secretion indices themselves were significantly improved at 5 weeks while the change of insulin sensitivity indices had no statistical difference.…”

“…For a supplementary analysis to validate the change of the β cell function, we also calculated the disposition index differently according to other previous reports as follows: 1) the product of the ΔIns 0-30 /ΔGlu 0-30 and the Matsuda index, where the ΔIns 0-30 /ΔGlu 0-30 represents the ratio of the incremental concentrations of insulin to those of glucose during the 0-to 30-min time period of the OGTT [11], 2) the product of the AUC Ins / AUC Glu and the Matsuda index, where AUC Ins / AUC Glu represents the ratio of area under the curve of insulin levels (μU. min/mL) to that of glucose levels (mg .…”

MECHANISMS IN ENDOCRINOLOGY: The endocrine role of the skeleton: background and clinical evidence

“…ucOC levels were higher in younger subjects and correlated positively with IGF1 (64). In healthy children, higher ucOC levels were associated with higher insulin secretion (65) as well as with higher high-molecular weight adiponectin, while children with prediabetes had lower ucOC concentrations and b-cell dysfunction (66). Acute insulin response to glucose challenge correlated negatively with ucOC in middle-school children (52).…”

Endocrine role of bone: recent and emerging perspectives beyond osteocalcin

“…In many human studies only total OC levels were quantified; however, the effects on glucose metabolism via bone are attributed to undercarboxylated OC. These studies yielded mixed results with several of them indicating a positive correlation between serum undercarboxylated OC levels and enhanced b-cell function (Hwang et al 2009, Prats-Puig et al 2010, Pollock et al 2011. However, results from other studies indicate no association between lower circulating uncarboxylated OC levels and higher HOMA-IR (Shea et al 2009).…”