Lower esophageal sphincter pressure, acid secretion, and blood gastrin after coffee consumption

Abstract

This study tested the hypothesis that differences in the processing of raw coffee beans can account for some of the variability in gastric effects of coffee drinking. Coffees were selected to represent several ways that green coffee beans are treated, ie, processing variables. These included instant and ground coffee processing, decaffeination method (ethyl acetate or methylene chloride extraction), instant coffee processing temperature (112 degrees F or 300 degrees F), and steam treatment. Lower esophageal sphincter pressure, acid secretion, and blood gastrin was measured in eight human subjects after they consumed each of the different coffees. Consumption of coffee was followed by a sustained decrease in lower esophageal sphincter pressure (P less than 0.05) except for three of the four coffees treated with ethyl acetate regardless of whether or not they contained caffeine. Caffeinated ground coffee stimulated more acid secretion that did decaf ground coffees (P less than 0.05), but not more than a steam-treated caffeinated coffee. Instant coffees did not differ in acid-stimulating ability. Ground caffeinated coffee resulted in higher blood gastrin levels than other ground coffees (P less than 0.05). Freeze-dried instant coffee also tended toward higher gastrin stimulation. It is concluded that some of the observed variability in gastric response to coffee consumption can be traced to differences in how green coffee beans are processed.

Effects of caffeine on alertness as measured by infrared reflectance oculography

“…As expected, the JDS scores were significantly reduced when the participants had consumed caffeine compared with a placebo. This effect was evident at 30 min and persisted for almost 3 h, which is consistent with the known pharmacokinetics of caffeine (Arnaud 1987;Liguori et al 1997;Van Deventer et al 1992).…”

Effects of Caffeine on Gastrointestinal Myoelectric Activity and Colonic Spike Activity in Dogs

“…C affeine is known to produce a wide range of effects on the gastrointestinal tract, including the pressure of the lower esophageal sphincter (LES) (1)(2)(3)(4)(5), gastric acid (1, 3, 6, 7) and intestinal water secretion (8,9), and colonic contractile activity (10)(11)(12)(13)(14)(15). Some investigators have reported the effects of caffeine on gastrointestinal motility and myoelectric activity.…”

Association between coffee or tea drinking and Barrett’s esophagus or esophagitis: an Italian study

“…The issue is controversial, but these characteristics might explain some of the variability in esophageal tissue response to coffee consumption. [39][40][41] The poorness of information did not allow us to better analyze some quantitative characteristics of tea consumption or to distinguish between green and black tea type. Anyway, it might be difficult to compare our results with other studies since the majority of Italian people consume black tea, and at low levels, while most reports on this topic are from Asian areas where green tea consumption is largely prevalent.…”