Lower cognitive test scores at age 7 in children born with marginally low birth weight

Starnberg, Josefine; Norman, Mikael; Westrup, Björn; Domellöf, Magnus; Berglund, Staffan

doi:10.1038/pr.2018.35

Cited by 10 publications

(7 citation statements)

References 25 publications

(43 reference statements)

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“…Everyday attention level was assessed with the Test of Everyday Attention for Children (TEA-Ch) in children older than 6 years (Heaton et al, 2001;Manly et al, 2001). The TEA-Ch test has previously been translated to Swedish and used for other clinical groups, such as 7-years-old children with low birth weight (Starnberg et al, 2018), but there are so far no Swedish norms on the test. The TEA-Ch is a test that assesses everyday attention capacity and is presented both in an auditory or visual modality.…”

Section: Methodsmentioning

confidence: 99%

Executive Functions, Pragmatic Skills, and Mental Health in Children With Congenital Cytomegalovirus (CMV) Infection With Cochlear Implants: A Pilot Study

et al. 2020

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Congenital cytomegalovirus (cCMV) infection is the most common cause of progressive hearing impairment. In our previous study around 90% of children with a cCMV infection and CI had severely damaged balance functions (Karltorp et al., 2014). Around 20% had vision impairment, 15% were diagnosed with Autism-Spectrum-Disorder, and 20% with ADHD. One clinical observation was that children with cCMV infection had problems with executive functioning (EF), while controls with a genetic cause of deafness (Connexin 26 mutations; Cx26) did not have similar difficulties. A follow-up study was therefore initiated with the main objective to examine EF and pragmatic skills in relation to mental health in children with a cCMV infection and to draw a comparison with matched controls with Cx26 mutations (age, sex, hearing, non-verbal cognitive ability, vocabulary, and socioeconomic status level). Ten children with a cCMV infection and CI (4.8-12:9 years) and seven children with CI (4:8-12:8 years) participated in the study, which had a multidisciplinary approach. Executive functioning was assessed both with formal tests targeting working memory and attention, parent and teacher questionnaires, and a systematic observation by a blinded psychologist during one test situation. Pragmatics and mental health were investigated with parent and teacher reports. In addition, the early language outcome was considered in non-parametric correlation analyses examining the possible relationships between later EF skills, pragmatics, and mental health. Children with cCMV had a statistically significant worse pragmatic outcome and phonological working memory than controls despite their groups having similar non-verbal cognitive ability and vocabulary. However, there were no statistical differences between the groups regarding their EF skills in everyday settings and mental health. There were associations between early language outcomes and later EF skills and pragmatics in the whole sample. Conclusion: Children with a cCMV infection are at risk of developing learning difficulties in school due to difficulties with phonological working memory and pragmatic skills in social interactions.

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Section: Methodsmentioning

confidence: 99%

Executive Functions, Pragmatic Skills, and Mental Health in Children With Congenital Cytomegalovirus (CMV) Infection With Cochlear Implants: A Pilot Study

et al. 2020

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“…This result is in line with literature showing an association between lower birth weight and poorer neurocognitive functioning. [41][42][43] The ndings of our study suggest that greater exposure to acidotic events during PICU admission is associated with poorer verbal memory outcome. In experimental studies several mechanisms have been…”

Section: Discussionmentioning

confidence: 65%

Predicting Long-term Neurocognitive Outcome after Pediatric Intensive Care Unit Admission - Exploring the Potential of Machine Learning

Sonnaville

Vermeule

Oostra

et al. 2023

Preprint

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Purpose: For successful prevention and intervention, it is important to unravel the complex constellation of factors that affect neurocognitive functioning after Pediatric Intensive Care Unit (PICU) admission. This study aims (1) to elucidate the potential relevance of patient and PICU-related characteristics for long-term neurocognitive outcome after PICU admission; and (2) to determine the potential of machine learning to improve outcome prediction. Methods: In this single-center cohort study we investigated 65 children aged 6-12 years with previous PICU admission for bronchiolitis (age ≤1 year). Patient and PICU-related characteristics used for the prediction models were: demographic characteristics, perinatal and disease parameters, laboratory results and intervention characteristics, including hourly validated mechanical ventilation parameters. Neurocognitive outcome was measured by intelligence and computerized neurocognitive testing. Prediction models were developed for each of the neurocognitive outcomes using Regression Trees, k-Nearest Neighbors and conventional Linear Regression analysis. Results: Lower intelligence was predicted by lower birth weight and lower socioeconomic status (R2 = 25.9%). Poorer performance on the Speed and Attention domain was predicted by younger age at follow-up (R2 = 53.5%). Poorer verbal memory was predicted by lower birth weight, younger age at follow-up, and greater exposure to acidotic events (R2 = 50.6%). The machine learning models did not reveal added value in terms of model performance as compared to Linear Regression. Conclusions: The findings of this study suggest that in children with previous PICU admission for bronchiolitis: (1) lower birth weight and lower socioeconomic status are associated to poorer neurocognitive outcome; and (2) greater exposure to acidotic events during PICU admission is associated with poorer verbal memory outcome. Findings of this study provide no evidence for added value of machine learning models as compared to linear regression analysis in the prediction of long-term neurocognitive outcome in a relatively small sample of children.

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“…Medical charts of all patients were available. Neonate weights between 1500 and 2499 g were assigned to the low-birth-weight (LBW) group, and those weighing between 500 and 1499 g to the very low birth weight (VLBW) group [2]. Multiple gestations were excluded from the analysis.…”

Section: Methodsmentioning

confidence: 99%

Umbilical Cord Thrombosis: A Rare but Life-threatening Occurrence

Tong

Xiao

Xie

et al. 2021

Preprint

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Background: Thrombosis of umbilical vessels is a rare but life-threatening pregnancy complication. The correct diagnosis and clinical management of umbilical cord thrombosis remain a challenge. This study aimed to evaluate the meaningful clinical manifestations and features of umbilical cord thrombosis and its optimal management options.Methods: This retrospective study analyzed umbilical cord thrombosis cases enrolled from January 1, 2011, to May 31, 2021. Data were collected from medical archives where the diagnoses of all patients were established by histopathology.Results: A total of 66 patients with umbilical cord thrombosis were enrolled, including 20 patients with intrauterine fetal death and 6 with fatal labor induction in the second trimester. The overall incidence of umbilical cord thrombosis was 0.05% (66/123,746), and the incidence increased significantly in the last 2 years, reaching 0.19% in 2021. The chief complaint was decreased fetal movement (25/60) or nonreactive nonstress test (NST) (19/40). In the 20 patients with intrauterine stillbirth, 8 patients had ignored fetal movement and were referred to the hospital because of ultrasound findings of intrauterine stillbirth. Five patients were misdiagnosed with a single umbilical artery on prenatal ultrasound. Twenty patients underwent emergency cesarean section due to decreased fetal movement and unresponsive fetal monitoring; all neonates were alive. The gross examination of the placenta and cord revealed umbilical cord abnormalities in 26 patients (39.4%, 26/66). The pathological examination revealed venous, venous and arterial, and arterial thrombosis in 74.2%, 12.1%, and 13.6% of patients, respectively.Conclusions: The main manifestation of umbilical cord thrombosis was decreased or disappeared fetal movement. The importance of self-counting fetal movement should be emphasized to patients. The abnormalities in the umbilical cord are the main cause of this phenomenon. Focus on counting fetal movements, electronic fetal monitoring, and specific signs during a prenatal ultrasound can help early identification of umbilical cord thrombi. Emergency cesarean section is recommended to reduce the risk of interrupting the umbilical cord blood flow.

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Lower cognitive test scores at age 7 in children born with marginally low birth weight

Cited by 10 publications

References 25 publications

Executive Functions, Pragmatic Skills, and Mental Health in Children With Congenital Cytomegalovirus (CMV) Infection With Cochlear Implants: A Pilot Study

Executive Functions, Pragmatic Skills, and Mental Health in Children With Congenital Cytomegalovirus (CMV) Infection With Cochlear Implants: A Pilot Study

Predicting Long-term Neurocognitive Outcome after Pediatric Intensive Care Unit Admission - Exploring the Potential of Machine Learning

Umbilical Cord Thrombosis: A Rare but Life-threatening Occurrence

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