Lower Cardiac Output Relates to Longitudinal Cognitive Decline in Aging Adults

Bown, Corey W.; Do, Rachel; Khan, Omair A.; Liu, Dandan; Cambronero, Francis E.; Moore, Elizabeth E.; Osborn, Katie E.; Gupta, Deepak K.; Pechman, Kimberly R.; Mendes, Lisa A.; Hohman, Timothy J.; Gifford, Katherine A.; Jefferson, Angela L.

doi:10.3389/fpsyg.2020.569355

Cited by 8 publications

(4 citation statements)

References 49 publications

(18 reference statements)

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“…All participants in the study were healthy adults. Thus, these data may not be generalizable to clinical populations or to older adults in which lower basal cardiac output has been related to worse cognitive decline ( Bown et al, 2020 ). Our findings may also not be generalizable to scenarios that do not involve isolation; however, isolation is required in studies investigating neurobehavioral and hemodynamic changes in high-fidelity space analogs, such as the present study, in order to simulate space flight conditions.…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress

et al. 2022

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There are substantial individual differences (resilience and vulnerability) in performance resulting from sleep loss and psychosocial stress, but predictive potential biomarkers remain elusive. Similarly, marked changes in the cardiovascular system from sleep loss and stress include an increased risk for cardiovascular disease. It remains unknown whether key hemodynamic markers, including left ventricular ejection time (LVET), stroke volume (SV), heart rate (HR), cardiac index (CI), blood pressure (BP), and systemic vascular resistance index (SVRI), differ in resilient vs. vulnerable individuals and predict differential performance resilience with sleep loss and stress. We investigated for the first time whether the combination of total sleep deprivation (TSD) and psychological stress affected a comprehensive set of hemodynamic measures in healthy adults, and whether these measures differentiated neurobehavioral performance in resilient and vulnerable individuals. Thirty-two healthy adults (ages 27–53; 14 females) participated in a 5-day experiment in the Human Exploration Research Analog (HERA), a high-fidelity National Aeronautics and Space Administration (NASA) space analog isolation facility, consisting of two baseline nights, 39 h TSD, and two recovery nights. A modified Trier Social Stress Test induced psychological stress during TSD. Cardiovascular measure collection [SV, HR, CI, LVET, BP, and SVRI] and neurobehavioral performance testing (including a behavioral attention task and a rating of subjective sleepiness) occurred at six and 11 timepoints, respectively. Individuals with longer pre-study LVET (determined by a median split on pre-study LVET) tended to have poorer performance during TSD and stress. Resilient and vulnerable groups (determined by a median split on average TSD performance) showed significantly different profiles of SV, HR, CI, and LVET. Importantly, LVET at pre-study, but not other hemodynamic measures, reliably differentiated neurobehavioral performance during TSD and stress, and therefore may be a biomarker. Future studies should investigate whether the non-invasive marker, LVET, determines risk for adverse health outcomes.

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Section: Discussionmentioning

confidence: 99%

Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress

et al. 2022

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“… 26 Reduced cardiac output has been associated with incident dementia and Alzheimer’s disease in the Framingham Heart Study 10 and accelerated cognitive decline in another cohort. 27 We observed lower 3-year incidence of neurocognitive diagnoses with sacubitril/valsartan vs ACEI/ARB. Although bias cannot be excluded in an observational study despite careful matching, we believe that the association of sacubitril/valsartan with lower cognitive event rates in patients with HFrEF in our study is plausible.…”

Section: Discussionmentioning

confidence: 57%

Sacubitril/Valsartan and Cognitive Outcomes in Heart Failure With Reduced Ejection Fraction

Grewal¹,

Abboud²,

Myserlis³

et al. 2023

JACC: Advances

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“…Recordamos que esta mejoría la obteníamos especialmente en memoria verbal, en la que, desde un nivel de partida inferior a la media poblacional, se alcanzaban rendimientos superiores, sobre todo en el grupo SAVR. La reducción del gasto cardíaco puede provocar hipoperfusión sistémica, disfunción vascular y accidentes isquémicos, lo que repercutiría, a la postre, en la función cognitiva, y ocasionaría déficits atencionales y en las funciones ejecutivas, fundamentalmente [ 27 , 33 ]. La alteración hemodinámica cerebral resultaría similar, en este caso, a la estenosis carotídea [ 34 ].…”

Section: Discussionunclassified

Deterioro cognitivo tardío en pacientes con estenosis aórtica tratados con sustitución valvular quirúrgica y con implantación transcatéter de válvula aórtica: estudio comparativo

Díaz Leiva,

Arrondo Gómez,

Alonso Sendín

et al. 2023

RevNeurol

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Introducción. El deterioro cognitivo secundario a eventos cerebrovasculares es una complicación frecuente en las intervenciones de reemplazo de válvula aórtica. Nuestro objetivo es el estudio del perfil de deterioro de los pacientes sometidos a reemplazo valvular quirúrgico o implantación de prótesis transcatéter (TAVI) y si éste resulta diferente según la intervención a la que son sometidos y los factores de riesgo basales. Pacientes y métodos. Estudio observacional prospectivo, con dos grupos no equivalentes de pacientes (grupo TAVI y grupo quirúrgico). Se realizaron comparaciones intergrupo en varios dominios cognitivos, con una evaluación basal y mediciones de seguimiento seis y 12 meses después la intervención. Resultados. El grupo TAVI presentó resultados inferiores al grupo quirúrgico en funciones ejecutivas y visuoespaciales, puntuaciones parcialmente determinadas por la edad ( p < 0,01) y el nivel intelectual previo (Pearson cociente intelectual previo-medias escalares en los test: 0,665; p < 0,001). La media de puntuaciones en los tres momentos de medición indica una disminución del rendimiento en funciones ejecutivas a los seis meses, que se recupera a los 12 meses. En memoria se registraron incrementos sostenidos en ambos momentos, en tanto que la función visuoespacial y la denominación no mostraron recuperación posterior de los niveles basales. Estas tendencias son similares en los dos grupos. Conclusión. Los resultados obtenidos no confirman la instauración de un proceso específico de deterioro neurocognitivo postintervención en la estenosis aórtica complicada. El perfil de deterioro no presenta diferencias significativas entre los grupos, pero es más evidente en los pacientes con TAVI, debido a la influencia de las variables de selección de la muestra.

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Lower Cardiac Output Relates to Longitudinal Cognitive Decline in Aging Adults

Cited by 8 publications

References 49 publications

Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress

Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress

Sacubitril/Valsartan and Cognitive Outcomes in Heart Failure With Reduced Ejection Fraction

Deterioro cognitivo tardío en pacientes con estenosis aórtica tratados con sustitución valvular quirúrgica y con implantación transcatéter de válvula aórtica: estudio comparativo

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