Lower body negative pressure: A test of cardiovascular autonomic function

Patel, Akash R.; Engstrom, Jennifer E.; Tusing, Lora; McNeeley, Kevin; Chelimsky, Thomas C.

doi:10.1002/mus.1030

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Orthostatic tests like stand test, tilt test and lower body negative pressure (LBNP) test are widely used for clinical and scientific purposes of investigating CV regulation 32 . The head-up tilt test is the method used for investigation of syncope, presyncope, dizziness and palpitations related to dysautonomia symptoms 33 .…”

Section: Techniques For Analysis Of Hp and Bp Induced Fluctuationsmentioning

confidence: 99%

Methodology of monitoring cardiovascular regulation

Bojić¹,

Radak

Putniković

et al. 2012

VOJNOSANIT PREGL

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Section: Techniques For Analysis Of Hp and Bp Induced Fluctuationsmentioning

confidence: 99%

Methodology of monitoring cardiovascular regulation

Bojić¹,

Radak

Putniković

et al. 2012

VOJNOSANIT PREGL

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“…This finding should be interpreted with caution, however, as LBNP (‒25 mmHg) was not found to reduce optic nerve sheath diameter in spaceflight, pointing to the limitations of terrestrial analogs to spaceflight 19 . LBNP has also been used to study hypovolemia 20 – 24 , autonomic responses 23 – 25 , and cardiovascular compensatory mechanisms 22 – 24 . Additionally, LBNP in other long duration experiments has allowed for the study of neurohumoral responses to measure plasma norepinephrine, renin, and aldosterone levels 26 .…”

Section: Introductionmentioning

confidence: 99%

Ocular perfusion pressure is not reduced in response to lower body negative pressure

Hall,

Whittle,

Diaz-Artiles

2024

npj Microgravity

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Lower body negative pressure (LBNP) has been proposed as a countermeasure to mitigate the cephalad fluid shift occurring during spaceflight, which may be associated with the development of Spaceflight Associated Neuro-ocular Syndrome (SANS). This study quantifies the effect of LBNP on intraocular pressure (IOP), mean arterial pressure at eye level (MAPeye), and ocular perfusion pressure (OPP). Twenty-four subjects (12 male, 12 female) were subjected to graded LBNP in 0° supine and 15° head-down tilt (HDT) postures from 0 mmHg to –50 mmHg in 10 mmHg increments. IOP decreased significantly with LBNP pressure in 0° supine (by 0.7 ± 0.09 mmHg per 10 mmHg LBNP pressure, p < 0.001) and in 15° HDT (by 1.0 ± 0.095 mmHg per 10 mmHg of LBNP pressure, p < 0.001). MAPeye significantly decreased by 0.9 ± 0.4 mmHg per 10 mmHg of LBNP pressure in 0° supine (p = 0.016) but did not significantly change with LBNP in 15° HDT (p = 0.895). OPP did not significantly change with LBNP in 0° supine (p = 0.539) but it significantly increased in 15° HDT at 1.0 ± 0.3 mmHg per 10 mmHg of LBNP pressure (p = 0.010). Sex did not have a significant effect on OPP, MAPeye, or IOP in any condition. In 15° HDT, the reduction in IOP during increasing negative pressure, combined with the relatively constant MAPeye, led to the increase in OPP. Furthermore, results suggest that LBNP, while effective in reducing IOP, is not effective in reducing OPP across all postures investigated.

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“…Lower body negative pressure evaluates sympathetic and parasympathetic cardiac functions and sympathetic vasomotor functions, through a progressive orthostatic stress provocation. 12…”

Section: Introductionmentioning

confidence: 99%

Auxiliary Tests of Autonomic Functions

Quispe

Novák

2021

Journal of Clinical Neurophysiology

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The autonomic nervous system is a complex neural network that controls several organ systems. Its assessment includes a detailed history of autonomic functions, clinical examination, and autonomic tests. Most widely used is a battery of tests that assess cardiovascular reflex autonomic and sudomotor tests, which include deep breathing (assesses parasympathetic function), Valsalva maneuver, tilt test (both assess parasympathetic and adrenergic functions), and sudomotor testing for the evaluation of postganglionic sudomotor fibers. These basic tests represent a foundation of autonomic testing. Nevertheless, the autonomic nervous system also controls organ systems not directly assessed by basic tests. This review describes a number of auxiliary autonomic tests that can be used in addition to basic autonomic tests or can be used independently to explore particular autonomic functions or to answer a specific clinical question. The auxiliary tests described in this review evaluate cardiovascular, thermoregulatory, gastrointestinal, genitourinary, eye, and exocrine functions. These tests are cold pressor test, sustained handgrip maneuver, reverse tilt test, venoarteriolar reflex, laser Doppler flare imaging, microneurography, neck suction, lower body negative pressure, venous occlusion plethysmography, pharmacologic assessment of postganglionic sympathetic outflow, plasma norepinephrine, sympathetic skin response, video cinefluoroscopic swallowing test, esophageal manometry test, small bowel manometry test, wireless motility capsule test, urodynamic studies, penile plethysmography, intracavernosal papaverine injection, infrared video pupillography, corneal confocal microscopy, pupillary response to dilute pilocarpine and hydroxyamphetamine, Schirmer test, tear osmolarity test, and salivary secretion test. The protocol of each test is described in detail. This review can be used as a quick reference for the auxiliary autonomic tests.

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Lower body negative pressure: A test of cardiovascular autonomic function

Cited by 6 publications

References 20 publications

Methodology of monitoring cardiovascular regulation

Methodology of monitoring cardiovascular regulation

Ocular perfusion pressure is not reduced in response to lower body negative pressure

Auxiliary Tests of Autonomic Functions

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