Methodology of monitoring cardiovascular regulation

Bojić, Tijana; Radak, Djordje; Putniković, Biljana; Alavantić, Dragan; Isenović, Esma R.

doi:10.2298/vsp110707019b

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…CONCLUSION. Central autonomic dynamics specific for sleep stages (13) causes peripheral consequences on CCV system and respiratory system, the supersystems (14,15,16,17,18,19,20,21) that can be pathologically changed. These peripheral effects can precipitate life-threatening CCV events that demand prompt and physiologically justified, sleep phase specific treatment.…”

Section: Nocturnal Cardiovascular Events Nocturnal Myocardial Infarctionmentioning

confidence: 99%

12th All-Russian Conference "Contradictions of Modern Cardiology: Controversial and unresolved issues". Collection of abstracts

Editorial

2023

Russ J Cardiol

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Section: Nocturnal Cardiovascular Events Nocturnal Myocardial Infarctionmentioning

confidence: 99%

12th All-Russian Conference "Contradictions of Modern Cardiology: Controversial and unresolved issues". Collection of abstracts

Editorial

2023

Russ J Cardiol

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“…NCVD are the syndromes where autonomic nervous system (Zoccoli et al, 2001 ; Bojic, 2003 ) dysfunction plays a dominant etiological role (Goldstain, 2001 ; Bojic et al, 2012a , b ). NCV disorders can be classified as sympathetically mediated disorders (i.e., neurogenic hypertension, NH) vs. vagally mediated disorders (i.e., vasovagal syncope, VVS), though in many disorders both systems are dysfunctional (Goldstain, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope

2016

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Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment.

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Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3

et al. 2016

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BackgroundThe pathophysiological overlapping between Sjorgen’s Syndrome (SS) and HCV, presence of anti- muscarinic receptor type 3 (M3R) antibodies in SS, the role that M3R plays in the regulation of the heart rate, has led to the assumption that cardiovagal dysfunction in HCV patients is caused by anti-M3R antibodies elicited by HCV proteins or by their direct interaction with M3R.ResultsTo identify HCV protein which possibly is crossreactive with M3R or which binds to this receptor, we performed the Informational Spectrum Method (ISM) analysis of the HCV proteome. This analysis revealed that NS5A protein represents the most probable interactor of M3R or that this viral protein could elicit antibodies which modulate function of this receptor. Further detailed structure/function analysis of NS5A and M3R performed by the ISM method extended with other Digital Signal processing (DSP) approaches revealed domains of these proteins which participate in their crossreactivity or in their direct interaction, representing promising diagnostic and therapeutic targets.ConclusionsApplication of the ISM with other compatible bioinformatics methods offers new perspectives for identifying diagnostic and therapeutic targets for complicated forms of HCV and other viral infections. We show how the electron-ion interaction potential (EIIP) amino-acid scale used in the ISM combined with a robust, high performance hydrophobicity scale can provide new insights for understanding protein structure/function and protein-protein interactions.

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Methodology of monitoring cardiovascular regulation

Abstract: nem

Cited by 3 publications

References 56 publications

12th All-Russian Conference "Contradictions of Modern Cardiology: Controversial and unresolved issues". Collection of abstracts

12th All-Russian Conference "Contradictions of Modern Cardiology: Controversial and unresolved issues". Collection of abstracts

In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope

Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3

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