Lower body mass index is not of more benefit for diabetic complications

Zhang, Yongze; Guo, Yangyang; Shen, Xiaodong; Zhao, Fengying; Yan, Sunjie

doi:10.1111/jdi.13003

Cited by 24 publications

(35 citation statements)

References 70 publications

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“…A cohort study conducted by Sairenchi et al [ 30 ] in Japan found that a lower BMI in older-adults 60 to 79 years old was associated with a higher risk of developing diabetic complications. Some authors have tried to explain this phenomenon by the fact that lean patients with diabetes have an accelerated loss of pancreatic beta-cells and poorer glycemic control [ 31 ]. However, this pathophysiological paradigm continues to be unanswered.…”

Section: Discussionmentioning

confidence: 99%

Comparison of prevalence of diabetes complications in Brazilian and Mexican adults: a cross-sectional study

et al. 2021

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Background Type 2 diabetes is more frequent in Latin American people than in non-Hispanic whites due to a combination of genetic and lifestyle risk factors. Brazil and Mexico are the most populous countries in Latin America. The present study aimed to compare the results of the National Health Survey “PNS” in Brazil and the National Survey Health and Nutrition “ENSANUT” in Mexico regarding the prevalence, complications and healthcare issues of diabetes in both countries. Methods A cross-sectional study was conducted with data from the National Health Survey (PNS) of 2013 in Brazil and the National Survey of Health and Nutrition (ENSANUT) of 2018 in Mexico. The prevalence of diabetes, complications and risk factors related to developing diabetes were considered. Results The respondents included 3636 individuals in Brazil and 4555 individuals in Mexico. There were significant differences in age and time living with diabetes between the two countries. Mexican people had twice as likely as Brazilian people to have a complication (p < 0.0001). The principal risk factor (OR 2.47; p ≤ 0.0001) for developing any diabetic complication was living with diabetes for more than 15 years. Visual impairment was the most frequent complication in both countries, but it was more prevalent in Mexico (p ≤ 0.001). Conclusions Diabetes complications are important health problems in Brazil and Mexico. Visual impairment was the principal complication in both countries. Several factors, such as access to and type of health system, living in a rural area, treatment, BMI and performing preventive actions, affected the risk of developing a complication. However, living with diabetes for more than 15 years was the principal risk factor. National health surveys have added significant information on the impact of diabetes in these Latin American populations. This comparison of data could provide valuable information to guide national policies and program decisions in both countries.

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Section: Discussionmentioning

confidence: 99%

Comparison of prevalence of diabetes complications in Brazilian and Mexican adults: a cross-sectional study

et al. 2021

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“…However, Xu et al hold a diverse view: lower BMI might be a latent risk factor for DPN [22]. Also, a new research from China in which they reported that lower BMI had a dangerous effect on diabetic complications [23]. In the multivariate regression linear analyses, we also found TC was negative with HASYM and FASYM, this is probably because lower TC may indicated that nutrition in patients with DPN was imbalance, which may negatively affected the rehabilitation of DPN [22].…”

Section: Discussionmentioning

confidence: 99%

Inverse Relationship Between Serum Cystatin C and Sudomotor Function Detected by SUDOSCAN in Chinese Patients With Type 2 Diabetes Mellitus

Guo¹,

Lü²,

Wang³

et al. 2020

Preprint

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Background and aims:To explore the relationship between serum cystatin C and sudomotor function produced by the SUDOSCAN in subjects with type 2 diabetes mellitus.Methods:The research incorporated 917 Chinese individuals with type 2 diabetes mellitus from May 2017 to May 2019. All patients underwent SUDOSCAN and examined cystatin C. SUDOSCAN was evaluated with electrochemical skin conductance in hands (HESC) and feet (FESC), asymmetry ratio in hands (HASYM) and feet (FASYM). Average FESC <60 µS was defined as sudomotor dysfunction. 917 patients were classified into 791 diabetic patients without sudomotor dysfunction, and 126 diabetic patients complicated with sudomotor dysfunction. The difference of cystatin C between two groups was compared firstly, the difference of SUDOSCAN metrics among tertiles of serum cystatin C was also compared. The spearman and multiple linear regression analyses were applied to analyze the association between serum cystatin C and SUDOSCAN metrics. Results:The total prevalence of sudomotor dysfunction was 13.74%. Patients with sudomotor dysfunction had a higher level of cystatin C (P<0.001). With increasing tertiles of serum cystatin C, ESC declined, ASYM elevated, and the prevalence of sudomotor dysfunction increased (P<0.001).The spearman analysis performed an association between serum cystatin C and SUDOSCAN metrics including HESC (r=-0.143, P<0.001), FESC(r=-0.178, P<0.001), HASYM (r=0.169, P<0.001), FASYM (r=0.174, P<0.001). Multivariate regression linear analyses demonstrated cystatin C was independently linked with HESC (B=-14.657, P<0.001) and FESC (B=-10.015, P=0.022) levels after controlling for potential confounders. Conclusions:Serum cystatin C is inversely linked with sudomotor function detected by SUDOSCAN in Chinese patients with type 2 diabetes mellitus.

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“…1). The diagnosis of T2DM was diagnosed based on the criteria presented by the American Diabetes Association [10]. Exclusion criteria were type 1 diabetes, gestational diabetes, diabetic ketoacidosis [11], hyperosmolar nonketotic coma, hepatic failure, fasting [12], patients who received SGLT-2 inhibitors, or who lacked data related to the levels of KBs.…”

Section: Study Populationmentioning

confidence: 99%

“…Plasma glucose was measured by glucose oxidase method using the AU2700 analyzer (Olympus Corporation, Tokyo, Japan) and specific reagents. The urinary albumin-tocreatinine ratio (UACR) was calculated as albumin concentration (mg/L) divided by creatinine concentration (g/L) [10]. The eGFR was calculated by the CKD-EPI creatinine equation ( 2009) that can be expressed as a single equation:…”

Section: Measurementmentioning

confidence: 99%

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The Value of Ketone Bodies in the Evaluation of Kidney Function in Patients with Type 2 Diabetes Mellitus

Zhang

Shen

et al. 2021

Journal of Diabetes Research

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Objectives. Recent studies have shown that the slightly elevated circulating levels of ketone bodies (KBs) played a significant role in the treatment of various diseases. This study is aimed at investigating the association between different levels of KBs and kidney function in patients with type 2 diabetes mellitus (T2DM). Methods. A retrospective study of 955 patients with T2DM (426 women and 529 men) admitted to our hospital from December 2017 to September 2019 was conducted. Patients were divided into different groups in line with the levels of KBs (low-normal group: 0.02-0.04 mmol/L, middle-normal group: 0.05-0.08 mmol/L, high-normal group: 0.09-0.27 mmol/L, and slightly elevated group: >0.27 and <3.0 mmol/L). Results. In the present study, individuals with high-normal levels of KBs had the lowest risk of diabetic kidney disease (DKD) and increased peak systolic velocity (PSV); those with middle-normal levels of KBs had the lowest risk of increased renal arterial resistive index (RI), with a positive correlation between increased α1-microglobulin and KB concentration. In addition, the indicators of glomerulus, renal tubules, and renal arteries were all poor with slightly elevated circulating levels of KBs, and KB concentration lower than 0.09 mmol/L can be applied as the threshold for low risk of renal function damage. Conclusions. In summary, slightly elevated circulating levels of ketone bodies are not of benefit for renal function in patients with type 2 diabetes mellitus.

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Lower body mass index is not of more benefit for diabetic complications

Cited by 24 publications

References 70 publications

Comparison of prevalence of diabetes complications in Brazilian and Mexican adults: a cross-sectional study

Comparison of prevalence of diabetes complications in Brazilian and Mexican adults: a cross-sectional study

Inverse Relationship Between Serum Cystatin C and Sudomotor Function Detected by SUDOSCAN in Chinese Patients With Type 2 Diabetes Mellitus

The Value of Ketone Bodies in the Evaluation of Kidney Function in Patients with Type 2 Diabetes Mellitus

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