Inverse Relationship Between Serum Cystatin C and Sudomotor Function Detected by SUDOSCAN in Chinese Patients With Type 2 Diabetes Mellitus

Abstract

Background and aims:To explore the relationship between serum cystatin C and sudomotor function produced by the SUDOSCAN in subjects with type 2 diabetes mellitus.Methods:The research incorporated 917 Chinese individuals with type 2 diabetes mellitus from May 2017 to May 2019. All patients underwent SUDOSCAN and examined cystatin C. SUDOSCAN was evaluated with electrochemical skin conductance in hands (HESC) and feet (FESC), asymmetry ratio in hands (HASYM) and feet (FASYM). Average FESC <60 µS was defined as sudomotor dysfunction. 917 patients were classified into 791 diabetic patients without sudomotor dysfunction, and 126 diabetic patients complicated with sudomotor dysfunction. The difference of cystatin C between two groups was compared firstly, the difference of SUDOSCAN metrics among tertiles of serum cystatin C was also compared. The spearman and multiple linear regression analyses were applied to analyze the association between serum cystatin C and SUDOSCAN metrics. Results:The total prevalence of sudomotor dysfunction was 13.74%. Patients with sudomotor dysfunction had a higher level of cystatin C (P<0.001). With increasing tertiles of serum cystatin C, ESC declined, ASYM elevated, and the prevalence of sudomotor dysfunction increased (P<0.001).The spearman analysis performed an association between serum cystatin C and SUDOSCAN metrics including HESC (r=-0.143, P<0.001), FESC(r=-0.178, P<0.001), HASYM (r=0.169, P<0.001), FASYM (r=0.174, P<0.001). Multivariate regression linear analyses demonstrated cystatin C was independently linked with HESC (B=-14.657, P<0.001) and FESC (B=-10.015, P=0.022) levels after controlling for potential confounders. Conclusions:Serum cystatin C is inversely linked with sudomotor function detected by SUDOSCAN in Chinese patients with type 2 diabetes mellitus.

Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

“…Overall, 15 studies with 1882 individuals were included. The studies were performed in Denmark 16 , Italy 15 , Mexico 17 , Poland 24 , and China 4 12 23 25 26 27 28 29 30 . All included studies were case-control studies and five were nested case-control studies.…”