Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

Osborne, Lauren M.; Gispen, Fiona; Sanyal, Abanti; Yenokyan, Gayane; Meilman, Samantha; Payne, Jennifer L.

doi:10.1016/j.psyneuen.2017.02.012

Cited by 139 publications

(94 citation statements)

References 55 publications

(55 reference statements)

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“…Whether these pathways also mediate the action of TIB in the hippocampus of females is unknown. It is important to mention that both allopregnanolone and TIB have been proposed as neuroprotective agents, and that allopregnanolone is currently considered as a candidate therapeutic agent in patients with AD and postpartum depression, another risk factor of AD ( 13 , 65 – 67 ).…”

Section: Hormone Actions and Their Relation To Neurodegenerative Disementioning

confidence: 99%

Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin

et al. 2018

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Sex differences are important to consider when studying different psychiatric, neurodevelopmental, and neurodegenerative disorders, including Alzheimer’s disease (AD). These disorders can be affected by dimorphic changes in the central nervous system and be influenced by sex-specific hormones and neuroactive steroids. In fact, AD is more prevalent in women than in men. One of the main characteristics of AD is the formation of neurofibrillary tangles, composed of the phosphoprotein Tau, and neuronal loss in specific brain regions. The scope of this work is to review the existing evidence on how a set of hormones (estrogen, progesterone, and prolactin) affect tau phosphorylation in the brain of females under both physiological and pathological conditions.

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Section: Hormone Actions and Their Relation To Neurodegenerative Disementioning

confidence: 99%

Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin

et al. 2018

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“…ALLO is a potent, positive allosteric modulator of the GABA A receptor, and it is through this mechanism that P4 exerts antidepressant, antianxiety, and HPA-axis modulatory effects. This research culminated in FDA approval for ALLO as a treatment of postpartum depression (Kanes et al, 2017;Osborne et al, 2017). Although we did not directly measure ALLO in this study, concentrations of P4 and ALLO are highly correlated in blood and in the CNS (e.g., correlation strength in serum ranging from .80 to .95) (Andréen et al, 2005;Freeman, Purdy, Coutifaris, Rickels, & Paul, 1993;Palliser, Kelleher, Tolcos, Walker, & Hirst, 2015).…”

Section: F I G U R Ementioning

confidence: 97%

Progesterone modulates theta oscillations in the frontal‐parietal network

et al. 2020

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The neuroactive metabolites of the steroid hormones progesterone (P4) and testosterone (T) are GABAergic modulators that influence cognition, yet, the specific effect of P4 and T on brain network activity remains poorly understood. Here, we investigated if a fundamental oscillatory network activity pattern, often related to cognitive control, frontal midline theta (FMT) oscillations, are modulated by steroids hormones, P4 and T. We measured the concentration of P4 and T using salivary enzyme immunoassay and FMT oscillations using high‐density electroencephalography (EEG) during eyes‐open resting‐state in 55 healthy women and men. Electrical brain activity was analyzed using Fourier analysis, aperiodic signal fitting, and beamformer source localization. Steroid hormone concentrations and biological sex were used as predictors for scalp and source‐estimated amplitude of theta oscillations. Elevated concentrations of P4 predicted increased amplitude of FMT oscillations across both sexes, and no relationship was found with T. The positive correlation with P4 was specific to the frontal midline electrodes and survived correction for the background aperiodic signal of the brain. Using source localization, FMT oscillations were localized to the frontal‐parietal network (FPN). Additionally, theta amplitude within the FPN, but not the default mode network, positively correlated with P4 concentration. Our results suggest that P4 concentration modulates brain activity via upregulation of theta oscillations in the FPN.

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“…Women with higher depression scores in late pregnancy have been found to have lower serum concentrations of allopregnanolone 69. Furthermore, in an exploratory study of 60 pregnant women with a previous diagnosis of mood disorder, higher concentrations of allopregnanolone during the second trimester were associated with a 63% (95% confidence interval 13% to 84%) reduction in the risk of developing postpartum depression (P=0.02) 70. Two double blind RCTs of a newly developed intravenous formulation of allopregnanolone, brexanolone (SAGE-547), have now been conducted.…”

Section: Personalized Treatment For Specific Clinical Characteristicsmentioning

confidence: 97%

Management of perinatal depression with non-drug interventions

Johansen

Robakis

Williams

et al. 2019

BMJ

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Perinatal depression is a common disorder that has been associated with serious risks to mother and child. Recently, screening for depression in pregnant and postpartum women has increased, as has the development of new psychotherapy and non-drug treatment modalities. Matching patients to treatments can be challenging, and although research into personalized treatment of major depression in the general population has increased, no published guidelines focus on personalized treatment approaches to perinatal depression. In particular, guidelines on non-drug treatments are lacking. This review summarizes the evidence on personalized non-drug treatment of perinatal depression, how to incorporate patients’ preferences, novel treatments under investigation, and the potential role of biomarkers in matching patients to treatment. The review provides recommendations for future research in personalized care of perinatal depression.

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Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

Cited by 139 publications

References 55 publications

Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin

Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin

Progesterone modulates theta oscillations in the frontal‐parietal network

Management of perinatal depression with non-drug interventions

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