Lower Airway Disease in Asthmatics with and without Rhinitis

Dixon, Anne E.; Raymond, Danielle M.; Suratt, Benjamin T.; Bourassa, Lorraine M.; Irvin, Charles G.

doi:10.1007/s00408-008-9119-1

Cited by 28 publications

(22 citation statements)

References 42 publications

(36 reference statements)

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“…IL-6 is one of the inflammatory cytokines that is produced by lung epithelial cells after allergen stimulation [27]. Sputum IL-6 was inversely associated with lower levels of postbronchodilator FEV 1 in asthma and asthma with rhinitis [28]. Quite recently a strong negative correlation has been reported between FEV 1 and sputum IL-6 levels [29].…”

Section: Discussionmentioning

confidence: 99%

IL-6 and IL-13 in Induced Sputum of COPD and Asthma Patients: Correlation with Respiratory Tests

et al. 2012

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Background: IL-6 is strongly implicated in the development of chronic obstructive pulmonary disease (COPD). IL-13 is the well-documented central mediator in allergic asthma. IL-6 is attributed to the proinflammatory activities in COPD as well as asthma. In COPD patients exacerbation is increased by serum IL-6. The association of IL-13 as well as IL-6 with the impaired respiratory function of asthma patients remains controversial. Objectives: The aim of this study was to compare the concentration of IL-6 and IL-13 in the induced sputum of asthma and COPD patients, and to assess the possible association of these cytokines with the impairment of lung function. Methods: Twenty-six subjects with COPD and 18 subjects with asthma were enrolled in this study. IL-6 and IL-13 levels were measured in induced sputum by ELISA and correlated with the results of respiratory tests. Results: The induced sputum of COPD patients had a significantly higher IL-6 level than the sputum of asthma subjects while no significant differences were found in the levels of IL-13. There was a statistically significant negative correlation between IL-6 level and FEV₁ or FEV₁/FVC in asthma patients (r = –0.59 and –0.54, respectively) and a negative correlation that did not reach statistical significance between IL-6 level and FEV₁, FEV₁% or FVC in COPD subjects (r = –0.30, –0.30 and –0.38, respectively). There was no relationship between concentrations of IL-13 and impaired respiratory function. Conclusions: Our results confirmed that IL-6, but not of IL-13, is associated with respiratory disorders in both asthma and COPD patients.

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Section: Discussionmentioning

confidence: 99%

IL-6 and IL-13 in Induced Sputum of COPD and Asthma Patients: Correlation with Respiratory Tests

et al. 2012

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“…Rhinitis is also common in nonallergic asthma [14] and it is actually underdiagnosed, particularly in primary care [26]. Overall, the literature suggests both children and adults with comorbid rhinitis and asthma have more frequent physician's visits, emergency room visits and hospital admissions for asthma, and higher asthma-related drug expenses [12,15,17,18,27].…”

Section: Upper Airways Diseasesmentioning

confidence: 99%

Influence of comorbid conditions on asthma

Lp¹

2009

European Respiratory Journal

220

169

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Various conditions such as rhinosinusitis, gastro-oesophageal reflux disease, psychological disturbances, chronic infections and obstructive sleep apnoea are often observed in asthmatic patients and may affect asthma control and outcomes. These comorbidities may change the asthma phenotype, be part of the same pathophysiological process, act as confounding factors in the diagnosis or assessment of control of asthma, and/or result from specific environmental exposures. The influences of these conditions on asthma are variable and for many of them still uncertain; nevertheless, they may alter asthma responses to current therapy. A systematic evaluation and an appropriate treatment of asthma-associated comorbid conditions should be part of asthma management, particularly for severe disease. With regard to clinical research, associated conditions may influence the results of trials and should be taken into account in the subjects' inclusion criteria and analysis of data.

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“…Ho we ver, they de fi ned a trend of fe wer eo si nop hils and ne ut rop hils in pa ti ents with low lung func ti ons whi le in so me ot her stu di es it was re por ted that in du ced spu tum eo si nop hili a was well cor re la ted with low lung func ti on. 46,47 We al so co uld not show any cor re la ti on bet we en in du ced spu tum cell com po si ti ons and lung func tions. So me stu di es sho wed a cor re la ti on bet we en BHR and eo si nop hi lic inf lam ma ti on 48 alt ho ugh some did not.…”

Section: Fi Gu Rementioning

confidence: 60%

Lower Airway Inflammation in Nonasthmatic Allergic Rhinitis Patients

Alpaydın¹,

Bora²,

Günhan³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Al ler gic rhi ni tis and ast hma ha ve be en con si de red as a sing le air way di se a se sha ring a com mon pat hoph ysi o lo gi cal mec ha nism of air way inf lam ma ti on. We ai med to in ves ti ga te the lo wer airway inf lam ma ti on in al ler gic rhi ni tis pa ti ents without ast hma. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Forty pa ti ents who refer red to our ter ti ary ca re hos pi tal's otor hi no lary ngo logy cli nic and di ag no sed as mo de ra te/se ve re per sis tent al ler gic rhi ni tis ac cor ding to ARI A cri te ri a we re inc lu ded in the study. Af ter eva lu a ti on for the eli gi bi lity for the study, a na sal sme ar was ta ken, and rhi no ma no metry was per for med to me a su re the na sal obs truc ti on on vi sit 1. Twenty-fo ur ho urs la ter from the vi sit 1, pul mo nary func ti ons inc lu ding bronc hi al hype rac ti vity (BHR) we re me a su red on vi sit 2. Twenty-fo ur ho urs la ter from the vi sit 2, spu tum in duc ti on was per for med, and cell dis tri bu ti on of the spu tums was eva lu a ted. R Re e s su ul lt ts s: : Me an age of the 17 ma le and 23 fe ma le pa ti ents was 37 ± 11. Na sal sme ar eo si nop hi li a was studied in 36 of the pa ti ents and fo und positive in 36%. Na sal obs truc ti on was de mons tra ted in 68% of the pa ti ents by rhi no ma no metry. BHR was po si ti ve in 30% of the parti ci pants. The re was not any sta tis ti cal sig ni fi cant re la ti ons hip bet we en na sal eo si nop hi li a and na sal obs truc ti on se ve rity, BHR and in du ced spu tum eo si nop hi li a (p> 0.05). Among the in du ced spu tums which we re of go od qu a lity to be eva lu a ted, 7.5% had an eo si nop hil ra ti o of 2%. Any re la ti ons hip bet we en in duced spu tum eo si nop hil per cen ta ges and FEV1, FEV1/FVC, na sal obs truc ti on se ve rity was not ob ser ved (p> 0.05). Ho we ver, BHR was fo und to be sig ni fi cantly re la ted with FEV1/FVC ra ti o which was >70% thro ugh the who le study po pu la ti on (r= 0.392 p= 0.012). C Co on nc c l lu u s si i o on n: : We co uld not de mons tra te the ex pec ted re la tions hip bet we en na sal and lo wer air way inf lam ma ti on mar kers in our study gro up of al ler gic rhi ni tis pa ti ents. This may be du e to the small num ber of study po pu la ti on and strict exc lu si on of ast hma tic pa ti ents as well as par ti cu larly the dif fi cul ti es in stan dar di za ti on of the in du ced spu tum tech ni qu e. K Ke ey y W Wo or rd ds s: : Rhi ni tis, al ler gic, pe ren ni al; spu tum; inf lam ma ti on me di a tors Ö ÖZ ZE ET T A Am ma aç ç: : Al ler jik ri nit ve as tım, ha va yol la rı nın inf la mas yo nu ile ka rak te ri ze ve or tak bir pa to fiz yo lo jik me ka niz ma yı pay la şan ha va yo lu has ta lık la rı ola rak ka bul edil mek te dir. Ça lış ma mız da, da ha ön ce as tım tanı sı al ma mış olan aler jik ri nit li has ta lar da alt so lu num yo lu inf la mas yo nu nu araş tır ma yı amaç la dık. G Ge e r re eç ç v ve e Y Yö ön ...

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Lower Airway Disease in Asthmatics with and without Rhinitis

Cited by 28 publications

References 42 publications

IL-6 and IL-13 in Induced Sputum of COPD and Asthma Patients: Correlation with Respiratory Tests

IL-6 and IL-13 in Induced Sputum of COPD and Asthma Patients: Correlation with Respiratory Tests

Influence of comorbid conditions on asthma

Lower Airway Inflammation in Nonasthmatic Allergic Rhinitis Patients

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