Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

Ren, Wen; Yu, Bing; Yu, Jie; Zheng, Ping; Huang, Zhiqing; Luo, Junqiu; Mao, Xiangbing; He, Jun; Yan, Hui; Wu, Jinlong; Chen, Shuai; Luo, Yuheng

doi:10.1007/s11427-021-2068-6

Cited by 28 publications

(14 citation statements)

References 53 publications

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“…The swine gut microbiome is now thought to play an integral role in growth, health, and disease ( 1 – 3 ). Persistent alterations in the composition, diversity, and function of the gut microbiome are increasingly being recognized as key factors in the establishment and maintenance of a growing number of disease states ( 4 ), including diarrhea ( 5 ) and constipation ( 6 ). The gut microbiome consists of bacteria, viruses, fungi, and archaea.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Investigation of Enteric Virome Signatures from Parental-Generation to Offspring Pigs

Zhang

Shi

et al. 2023

Microbiol Spectr

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Section: Introductionmentioning

confidence: 99%

Longitudinal Investigation of Enteric Virome Signatures from Parental-Generation to Offspring Pigs

Zhang

Shi

et al. 2023

Microbiol Spectr

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“…The digestive system of piglets is not mature both before and immediately after weaning, and the overall digestive function of the animals is relatively weak at this stage. After weaning, stress resulting from abrupt changes in dietary structure and feeding environment, among other causes, is very likely to cause intestinal barrier destruction, intestinal dysbiosis and immune decline in weaned piglets, leading to diarrhea ( Ren et al, 2022 ). Post-weaning diarrhea is caused by bacteria such as E. coli ( Huang et al, 2018 ), Salmonella ( Kylla et al, 2019 ), and Clostridium perfringens ( Songer, 2010 ) and represents one of the most serious problems facing the swine industry worldwide.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs

Ouyang,

Chen,

Sun

et al. 2024

Front. Microbiol.

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Antimicrobial peptides could inhibit the growth of harmful bacteria and promote the growth performance in weaned piglets. Here, we investigated the effects of dietary supplementation with cecropin antimicrobial peptides (CAP) on growth performance, diarrhea rate, intestinal health in nursery Hainan piglets. For this, 120 healthy nursery Hainan male piglets (13.29 ± 0.29 kg, 44 days old) were randomly divided into 5 groups—a control (CON) group (fed a basal diet), an antibiotic control (AC) group (fed a basal diet supplemented with 250 mg/kg colistin sulfate); and 3 experimental groups (provided the basal diet supplemented with 250, 500, or 1,000 mg/kg CAP). Pre-feeding lasted 7 days and the official period lasted 40 days. The results showed that compared with the CON group, dietary supplementation of 500 mg/kg CAP had significantly increased the average daily gain (ADG, p < 0.05), while the feed conversion ratio (FCR) and diarrhea rate were markedly reduced (p < 0.05), serum total protein (TP), albumin, IgA, IgM, and globulin concentrations were significantly increased (p < 0.05), where serum aspartate aminotransferase (AST) level was significantly reduced (p < 0.05), and it also increased the villus height and the villus height-to-crypt depth ratio in the jejunum, reduced the serum D-lactic acid concentrations and diamine oxidase activity, and increased the expression level of ZO-1 and occludin in the jejunum and ileum (p < 0.05), the relative abundance of Firmicutes, Lactobacillus, and Limoslactobacillus in the colon were increased (p < 0.05), whereas that of Streptococcus and Escherichia–Shigella were reduced (p < 0.05). These results indicated that dietary supplementation with 500 mg/kg CAP could improve the growth performance, reduce the diarrhea rate, improve the serum immunity, intestinal health of nursery pigs.

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“…Regarding Bacteroidetes, n-3 LCFA increased the Bacteroides genus, which is one of the core bacterial genera of pigs’ microbiota and is reported to be found in more than 90% of healthy pigs of different ages ( Luo et al, 2022 ). Moreover, as described above for A. muciniphila , genus Bacteroides is also considered to be a mucin glycan degrader ( Bell and Juge, 2021 ) and its low abundance has been associated with post-weaning diarrhea ( Ren et al, 2022 ). It should be mentioned that n-3 LCFA also decreased Prevotella copri species, which are present during lactation at low abundances but increase drastically upon weaning ( Amat et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Influence of dietary n-3 long-chain fatty acids on microbial diversity and composition of sows’ feces, colostrum, milk, and suckling piglets’ feces

et al. 2022

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IntroductionVery little is known about the impact of n-3 long-chain fatty acids (n-3 LCFAs) on the microbiota of sows and their piglets. The aim of this study was to evaluate the effect of n-3 LCFA in sow diets on the microbiota composition of sows’ feces, colostrum, and milk as well as that of piglets’ feces.MethodsTwenty-two sows were randomly assigned to either a control or an n-3 LCFA diet from service to weaning. Sows’ and piglets’ performance was monitored. The gestating and lactating sows’ microbiomes in feces, colostrum, and milk were characterized by 16s ribosomal RNA gene sequencing. The fecal microbiome from the two lowest (>800 g) and the two highest birth weight piglets per litter was also characterized, and the LPS levels in plasma were analyzed at weaning.Results and Discussionn-3 LCFA increased microbiota alpha diversity in suckling piglets’ and gestating sows’ feces. However, no effects were observed in colostrum, milk, or lactating sows’ feces. Dietary n-3 LCFA modified the microbiota composition of gestating sows’ feces, milk, and suckling piglets’ feces, without affecting lactating sows’ feces or colostrum. In gestating sows’ feces and milk, the decrease in genus Succinivibrio and the increase of Proteobacteria phylum, due to the increased genera Brenneria and Escherichia, respectively, stand out. In the feces of suckling piglets, the higher abundance of the beneficial genus Akkermansia and Bacteroides, and different species of Lactobacillus are highlighted. In addition, positive correlations for families and genera were found between lactating sows’ feces and milk, milk and suckling piglets’ feces, and lactating sows’ feces and suckling piglets’ feces. To conclude, dietary n-3 LCFA had a positive impact on the microbiome of suckling piglet’s feces by increasing microbial diversity and some beneficial bacteria populations, had a few minor modifications on the microbiome of milk and gestating sows’ feces and did not change the microbiome in lactating sows’ feces or colostrum. Therefore, this study shows the effect of dietary n-3 LCFA on the microbiota of sows, colostrum, milk, and suckling piglets during the lactation period providing crucial information on the microbiota status at the early stages of life, which have an impact on the post-weaning.

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Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

Cited by 28 publications

References 53 publications

Longitudinal Investigation of Enteric Virome Signatures from Parental-Generation to Offspring Pigs

Longitudinal Investigation of Enteric Virome Signatures from Parental-Generation to Offspring Pigs

Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs

Influence of dietary n-3 long-chain fatty acids on microbial diversity and composition of sows’ feces, colostrum, milk, and suckling piglets’ feces

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