Longitudinal Investigation of Enteric Virome Signatures from Parental-Generation to Offspring Pigs

Qu, Chen; Zhang, Xiaojun; Shi, Wenhao; Du, Xizhong; Ma, Lingyan; Wang, Wen; Tao, Shiyu; Xiao, Yingping

doi:10.1128/spectrum.00023-23

Cited by 1 publication

(1 citation statement)

References 52 publications

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“…Here, we revealed that gut phages in pigs were predicted to infect a broad range of 14 phyla of prokaryotes, such as Bacteroidota , Bacillota , Pseudomonadota , and Actinomycetota , that were consistent with previous studies on the neonatal piglets [ 48 ] and weaned pigs [ 47 ]. Previous studies showed that gut phages in pigs were predicted to infect several genera of prokaryotes, such as Clostridium , Lactobacillus , Bacillus , Streptococcus , and Bacteroides [ 25 , 52 , 56 , 57 ], that were also consistent with our data. However, previous studies rarely revealed the host species level-taxonomic composition of gut phages in pigs.…”

Section: Discussionsupporting

confidence: 92%

Characterizing the gut phageome and phage-borne antimicrobial resistance genes in pigs

Hu,

Chen,

Nie

et al. 2024

Microbiome

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Background Mammalian intestine harbors a mass of phages that play important roles in maintaining gut microbial ecosystem and host health. Pig has become a common model for biomedical research and provides a large amount of meat for human consumption. However, the knowledge of gut phages in pigs is still limited. Results Here, we investigated the gut phageome in 112 pigs from seven pig breeds using PhaBOX strategy based on the metagenomic data. A total of 174,897 non-redundant gut phage genomes were assembled from 112 metagenomes. A total of 33,487 gut phage genomes were classified and these phages mainly belonged to phage families such as Ackermannviridae, Straboviridae, Peduoviridae, Zierdtviridae, Drexlerviridae, and Herelleviridae. The gut phages in seven pig breeds exhibited distinct communities and the gut phage communities changed with the age of pig. These gut phages were predicted to infect a broad range of 212 genera of prokaryotes, such as Candidatus Hamiltonella, Mycoplasma, Colwellia, and Lactobacillus. The data indicated that broad KEGG and CAZy functions were also enriched in gut phages of pigs. The gut phages also carried the antimicrobial resistance genes (ARGs) and the most abundant antimicrobial resistance genotype was diaminopyrimidine resistance. Conclusions Our research delineates a landscape for gut phages in seven pig breeds and reveals that gut phages serve as a key reservoir of ARGs in pigs.

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