Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016

Mathé, Philipp; Egah, DZ; Müller, Janis A.; Shehu, Nathan Y.; Obishakin, Emmanuel; Shwe, David; Pam, VC; Okolo, Mark Ojogba; Yilgwan, Christopher; Gomerep, Simji Samuel; Fuchs, Jonas; Abok, Ibrahim I; Onyedibe, Kenneth I.; Olugbo, Ewa J.; Isa, Samson Ejiji; Machunga-Mambula, Salamatu S.; Attah, Caleb Joseph; Münch, Jan; Oguche, Stephen; Panning, Marcus

doi:10.1016/j.jcv.2018.05.011

Cited by 25 publications

(27 citation statements)

References 24 publications

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“…Of interest, when modeling our data we concluded that the most probable mode of transmission in the tropical savannah region was nonepidemic and associated with low seroprevalence values, which is reminiscent of the low-rate endemic transmission that has been reported in Central Africa (Cameroon and Congo) (17,27) and West Africa (28,31). This transmission may correspond in part to sylvatic exposure.…”

Section: Discussionmentioning

confidence: 53%

“…We found an average ZIKV seroprevalence of ≈12%, ranging from 3.1% to 20.2% depending on the study site. Seroprevalence was higher than expected because recent surveys conducted in several Central and West Africa countries reported lower values: ≈5% in Cameroon (17), 0.1% in the Democratic Republic of the Congo (27) and 3.4% in Nigeria (28). Those countries have ecoclimatic conditions that have been typically associated with the circulation of ZIKV and its implication in the transmission to humans by peridomestic mosquitoes (i.e., tropical forested areas with nonhuman primates and sylvatic Aedes spp.…”

Section: Discussionmentioning

confidence: 87%

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Zika Virus Circulation in Mali

Diarra¹,

Nurtop²,

Sangaré³

et al. 2020

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 87%

Zika Virus Circulation in Mali

Diarra¹,

Nurtop²,

Sangaré³

et al. 2020

Emerg. Infect. Dis.

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“…Recently, a number of serosurveys of ZIKV infections have been conducted in Oceania, Africa, Latin America, and the Caribbean. The seroprevalence was high in Micronesia (73%) [23], Brazil (63.3%) [24], Nicaragua (36 – 56%) [25], French Polynesia (49%) [26], Martinique (42.2%) [27], Bolivia (0 – 39%) [28], Suriname (35.1%) [29], French Guiana (18.8%) [30], Saudi Arabia (12.68%) [31], and Nigeria (10%) [32], but was less than 10% in Laos (9.9%) [33], Indonesia (9.1%) [17], Zambia (6.1%) [34], Cameroon (5%) [35], Rwanda (1.4%) [36], and Kenya (0.24 – 7.11%) [37]. However, the laboratory assays used were varied across the studies.…”

Section: Discussionmentioning

confidence: 99%

Low seroprevalence of Zika virus infection among adults in Southern Taiwan

Chien

Huang

et al. 2019

BMC Infect Dis

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BackgroundWe recently conducted a serosurvey of newly arrived workers in Taiwan from four Southeast Asian countries which revealed that 1% of the migrant workers had laboratory-confirmed recent Zika virus (ZIKV) infection. Taiwan, where Aedes mosquitoes are prevalent, has a close relationship with Southeast Asian countries. Up to now, 21 imported cases of ZIKV infection have been reported in Taiwan, but there has been no confirmed indigenous case. The aim of this serosurvey was to assess whether there was unrecognized ZIKV infections in Taiwan.MethodsA total of 212 serum samples collected in a cross-sectional seroepidemiologic study conducted during the end of the 2015 dengue epidemic in Tainan, Taiwan, were analyzed. Anti-ZIKV IgM and IgG were tested using commercial enzyme-linked immunosorbent assays (ELISAs). Plaque reduction neutralization tests (PRNTs) for ZIKV and four dengue virus (DENV) serotypes were performed for samples with positive anti-ZIKV antibodies. A confirmed case of ZIKV infection was defined by ZIKV PRNT90 titer ratio ≥ 4 compared to four DENV serotypes.ResultsThe mean age of the 212 participants was 54.0 years (standard deviation 13.7 years), and female was predominant (67.0%). Anti-ZIKV IgM and IgG were detected in 0 (0%) and 9 (4.2%) of the 212 participants, respectively. For the 9 samples with anti-ZIKV IgG, only 1 sample had 4 times higher ZIKV PRNT90 titers compared to PRNT90 titers against four dengue virus serotypes; this individual denied having traveled abroad.ConclusionsThe results suggest that undetected indigenous ZIKV transmission might have occurred in Taiwan. The findings also suggest that the threat of epidemic transmission of ZIKV in Taiwan does exist due to extremely low-level of herd immunity. Our study also indicates that serological tests for ZIKV-specific IgG remain a big challenge due to cross-reactivity, even in dengue non-endemic countries.

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“…Serological data suggest that ZIKV transmission has occurred among humans, animals and mosquitoes throughout tropical Africa for more than 70 years; however, ZIKV epidemics were never reported, and fewer than 20 human infections were recorded [ 3 ] between its isolation and the first large epidemic, occurring in Micronesia in 2007 [ 4 ]. ZIKV gained new attention after its spread in the Pacific and then to the Americas [ 5 ], and in recent years serological studies were conducted in Africa, documenting the presence of ZIKV antibodies in humans [ 6 , 7 , 8 , 9 ]. Moreover, a ZIKV outbreak that occurred in Gabon in 2007 was retrospectively identified [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Zika Virus in West Africa: A Seroepidemiological Study between 2007 and 2012

Marchi

Viviani

Montomoli

et al. 2020

Viruses

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According to the World Health Organization, the entire African continent is at risk of a Zika outbreak. To increase data availability on the epidemiology of Zika virus circulation in Africa, we evaluated the immunity to Zika virus in a selected cohort of subjects from West Africa between 2007 and 2012. Human serum samples were collected in 2007 and in 2011/2012 from a cohort of 2–29-year-old subjects from Mali, Senegal, and The Gambia. A sample that tested positive by Zika virus IgG ELISA and by Zika virus microneutralization test was defined as positive. In 2007, the highest prevalence was 21.9%, found in Senegal among 18–29-year-old subjects. In 2011/2012, the highest prevalence, 22.7%, was found still in Senegal, but in 11–17-year-old subjects. During both study periods, the lowest prevalence was found in Mali, where few positive cases were found only in 18–29-year-old subjects. The Gambia showed an intermediate prevalence. In the three countries, prevalence was strongly associated with increasing age. This study contributes to understanding Zika virus circulation within three different ecological and demographic contexts with scarce or no data currently available. Results showed that Zika virus circulated actively in West Africa between the period 2007 and 2011/2012, but with some geographic specificity.

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Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016

Cited by 25 publications

References 24 publications

Zika Virus Circulation in Mali

Zika Virus Circulation in Mali

Low seroprevalence of Zika virus infection among adults in Southern Taiwan

Zika Virus in West Africa: A Seroepidemiological Study between 2007 and 2012

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