Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease

Yang, Bing‐Bing; Chen, Yuan-Hua; Zhang, Cheng; Shi, Chang-E.; Hu, Kaifeng; Zhou, Ju; D, Xu; Chen, Xi

doi:10.1007/s12020-016-1152-x

Cited by 18 publications

(21 citation statements)

References 52 publications

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“…Also, Nelson et al [20] 2016, found that low levels of vitamin D are associated with high risk of NASH in patients with NAFLD. Our results are also in agreement with Zhai et al [21] 2016, Wang et al [22] 2016, Yang et al [23] 2017 and Eliades et al [8] meta-analysis 2013 who reported that vitamin D deficient patients have 1.26-fold increased risk for NAFLD than those with sufficient vitamin D.…”

Section: Discussionsupporting

confidence: 92%

Vitamin D Levels in Egyptian Patients With Non-Alcoholic Fatty Liver Disease

Shawky

Hassan²,

Mohammed³

et al. 2018

Journal of Gastroenterology and Hepatology Research

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BACKGROUND/AIM: An association between non-alcoholic fatty liver disease (NAFLD) and serum vitamin D levels is thought to exist. However, the definite role and mechanisms are unknown. Aim: we aimed to investigate serum vitamin D levels in patients with NAFLD. METHODS: Fifty patients with NAFLD and another 50 healthy volunteers without NAFLD or any clinically apparent liver diseases were enrolled in this study. Diagnosis of NAFLD is based on ultrasound (U.S) findings after exclusion of other possible causes of NAFLD and chronic liver diseases. Serum 25(OH) vitamin D levels were measured using ELISA based test. RESULTS: There are statistically significant decrease of serum 25(OH) vitamin D levels in patients with NAFLD than those without NAFLD. Serum 25(OH) vitamin D level is inversely correlated with body mass index (BMI), total cholesterol, triglycerides, low density lipoprotein (LDL) and age. CONCLUSION: Serum 25(OH) vitamin D level is inversely associated with NAFLD.

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Section: Discussionsupporting

confidence: 92%

Vitamin D Levels in Egyptian Patients With Non-Alcoholic Fatty Liver Disease

Shawky

Hassan²,

Mohammed³

et al. 2018

Journal of Gastroenterology and Hepatology Research

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“…As the main source of cytokines, T cells, especially CD4 + T cells were reported to be critical in the development of pancreatitis [8, 10]. We checked CD4 + and CD8 + ratio in both peripheral blood mononuclear cells (PBMCs) and spleen mononuclear cells (MNCs).…”

Section: Resultsmentioning

confidence: 99%

“…The role of T cells in the development of both acute and chronic pancreatitis has been well documented [4, 7]. T cells, especially CD4 + T cells contributed to the progress of acute pancreatitis, evidenced by depletion of CD4 + T cells but not CD8 + T cells significantly reduced the severity of acute pancreatitis [8]. In chronic pancreatitis, significant increase in CD4 + and CD8 + T-cell infiltration was observed in pancreas of patients with chronic pancreatitis [9].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

Chen

Bian

et al. 2017

Cell Physiol Biochem

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Background/Aims: Chronic pancreatitis is an inflammatory disease of the pancreas characterized by progressive tissue destruction and fibrogenesis. The development of chronic pancreatitis is associated with immune cell dysregulation. Currently, the specific and effective treatment of chronic pancreatitis remains absent. Methods: By using an L-arginine induced chronic pancreatitis mouse model, we tested the therapeutic potential of hydrogen, a strong hydroxyl radicals scavenger, in the chronic pancreatitis model. Tissue inflammation, damage and fibrosis were analyzed on HE, TUNEL, MPO, and sirius staining. Pancreas levels of MDA content, SOD activity, TNF-α , IL-10 cytokine expression and serum amylase and lipase activity were determined by ELISA and absorbance assay. Apoptosis, T cells subtype proportion and intracellular level of reactive oxygen species (ROS) were analyzed by flow cytometry. Tregs adoptive transfer and CD25 neutralization were used to validate the role of Tregs in chronic pancreatitis. Results: We found that hydrogen treatment significantly improved multiple symptoms of chronic pancreatitis. The number of Tregs was reduced in chronic pancreatitis mice, while hydrogen treatment restored the Treg loss by L-arginine administrations. Depletion of Tregs abolished the protective effect of hydrogen treatment in chronic pancreatitis. In vitro study showed that hydrogen blocked ROS generation in Tregs and promoted Tregs survival. Conclusion: Hydrogen treatment showed reliable benefits in controlling the severity of chronic pancreatitis. Our study supported that hydrogen could be used as a novel treatment in chronic pancreatitis patient in the future.

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“…The relationship between vitamin D and NAFLD has also been a research hotspot in recent years . We previously demonstrated that serum vitamin D levels were much lower in patients with NAFLD than in patients without NAFLD.…”

Section: Discussionmentioning

confidence: 98%

The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

Shen

et al. 2018

Clin Exp Pharma Physio

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Recent studies have shown that circulating fibroblast growth factor (FGF) 23 and vitamin D levels are closely correlated with insulin resistance. The aim of this study was to investigate the relationship among serum FGF 23 levels, serum 25-hydroxyvitamin D [25(OH)D] levels, and non-alcoholic fatty liver disease (NAFLD) in Chinese patients with type 2 diabetes mellitus (T2DM). This study enrolled 331 hospitalized T2DM patients (209 patients with NAFLD and 122 patients without NAFLD). Serum FGF23 levels were measured using a sandwich enzyme-linked immunosorbent assay. Serum 25(OH)D levels were determined by an electrochemiluminescence immunoassay. NAFLD was diagnosed by hepatic ultrasound, and the fatty liver index (FLI) was calculated to quantify hepatic steatosis. Results showed that T2DM patients with NAFLD had significantly higher serum FGF23 levels (44.17 [37.92-51.30] pg/mL vs 40.21 [34.07-48.33] pg/mL, P = .002), but lower serum 25(OH)D levels (16.43 [12.70-21.37] ng/mL vs 19.59 [13.78-26.26] ng/mL, P = .002) than those without NAFLD. Moreover, the incidence rate of NAFLD increased with increasing serum FGF23 levels and decreased with increasing 25(OH)D levels (both P < .05). Logistic regression analysis showed that both serum FGF23 and 25(OH)D levels were independent factors for NAFLD (both P < .05). Furthermore, a multiple stepwise regression analysis also revealed that both serum FGF23 and 25(OH)D levels were independently correlated with FLI (both P < .01). In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver.

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Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease

Cited by 18 publications

References 52 publications

Vitamin D Levels in Egyptian Patients With Non-Alcoholic Fatty Liver Disease

Vitamin D Levels in Egyptian Patients With Non-Alcoholic Fatty Liver Disease

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

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