Vitamin D Levels in Egyptian Patients With Non-Alcoholic Fatty Liver Disease

Abstract

BACKGROUND/AIM: An association between non-alcoholic fatty liver disease (NAFLD) and serum vitamin D levels is thought to exist. However, the definite role and mechanisms are unknown. Aim: we aimed to investigate serum vitamin D levels in patients with NAFLD. METHODS: Fifty patients with NAFLD and another 50 healthy volunteers without NAFLD or any clinically apparent liver diseases were enrolled in this study. Diagnosis of NAFLD is based on ultrasound (U.S) findings after exclusion of other possible causes of NAFLD and chronic liver diseases. Serum 25(OH) vitamin D levels were measured using ELISA based test. RESULTS: There are statistically significant decrease of serum 25(OH) vitamin D levels in patients with NAFLD than those without NAFLD. Serum 25(OH) vitamin D level is inversely correlated with body mass index (BMI), total cholesterol, triglycerides, low density lipoprotein (LDL) and age. CONCLUSION: Serum 25(OH) vitamin D level is inversely associated with NAFLD.

The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study

“…Till now, there are no studies on Egyptians that have examined the association of vitamin D deficiency on the risk of ACS. However, there are some that studied the association of vitamin D deficiency on other disorders such as Non Alcoholic Fatty Liver Disease (NAFLD) [35] and rheumatoid arthritis [36]. Both studies portrayed results similar to those displayed in the current study.…”

Non-alcoholic fatty liver disease is associated with decreased bone mineral density in upper Egyptian patients

“…Our results agree with Targher et al who reported a potential link between decreased serum vitamin D and low BMD in patients with NAFLD 19 . Moreover, many studies proved that patients with NAFLD have lower levels of serum vitamin D than controls which lead to decrease BMD and increase risk of fractures [35][36][37][38] . Our study showed that patients with NAFLD had increased level of PTH compared to controls which indicates that patients with NAFLD had low BMD and OP.…”