Low vitamin D, and bone mineral density with depressive symptoms burden in menopausal and postmenopausal women

Bener, Abdulbari; Saleh, N.

doi:10.4103/0976-7800.165590

Cited by 17 publications

(16 citation statements)

References 24 publications

(111 reference statements)

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“…The present research highlighted the importance of considering psychosocial factors, life style, and chronic disease management in providing health guidance for peri-menopausal women and postmenopausal women to enhance their quality of life and reduce the risk of depressive and stress symptoms, this consistent with the previous reported studies. [67891328] Furthermore, the current data suggest that there is a strong association between depression, anxiety and stress symptoms high rates in menopause and postmenopausal women: These findings are confirmative with some previous reported studies. [6789132122232425262728]…”

Section: Discussionsupporting

confidence: 92%

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Bener

Bakır

et al. 2016

Ann Med Health Sci Res

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Background:The association between depression, anxiety, and stress among Arab menopause and postmenopausal women have been explored in detailed.Aim:The objective of this study was to determine the correlation between depression, anxiety, and stress in menopausal and postmenopausal women and shedding more light on a complex relationship.Subjects and Methods:A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian women at the primary health care centers in Qatar. A representative sample of 1468 women aged 45–65 years were approached during July 2012 and May 2014 and 1101 women agreed to participate (75.0%) and responded to the study. Depression, anxiety, and stress were measured using the Depression Anxiety Stress Scales 21. Data on body mass index (BMI), clinical and other parameters were used. Univariate, multivariate, and matrix correlation analysis were performed for statistical analysis.Results:A total of 1101 women agreed to participate after informed consent was obtained. The mean age and standard deviation (SD) of the menopausal age were 49.55 (3.12), the mean and SD of postmenopausal age was 58.08 (3.26) (P < 0.001). There were statistically significant differences between menopausal stages with regards to age, ethnicity, educational status, occupation status, and place of living. Furthermore, there were statistically significant differences between menopausal stages with regards to BMI, systolic and diastolic blood pressure (BP), Vitamin D deficiency, and diseases. Depression and anxiety were more common among postmenopause women. Furthermore, there were no differences between the groups regarding the frequency of certain levels of stress among menopause and postmenopause. The multivariate regression analyses revealed that age in years, diastolic BP, consanguinity, regular exercise were a predictor for depression. Meanwhile, diastolic BP, occupation, and physical activity considered the main risk factors for anxiety. Furthermore, age in years, occupation, and sheesha smoking habits were considered as the main risk factors associated with stress.Conclusion:A large number of factors were associated with experiencing menopausal and psycho-social problems and which had negative effects on the quality of life among Arabian women. Depression, anxiety, and stress should be considered as important risk factors for osteoporosis.

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Section: Discussionsupporting

confidence: 92%

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Bener

Bakır

et al. 2016

Ann Med Health Sci Res

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“…Similar studies done in various part of the world demonstrated that BMD had no significant relation to serum 25(OH)D status [8,[20][21][22][23]. However, a few studies have shown a positive correlation of serum 25(OH)D levels and BMD [24][25][26].…”

Section: Discussionmentioning

confidence: 82%

Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

Ahmed¹,

Haque²,

Uddin³

et al. 2019

IMC J Med Sci

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Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD. Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined. Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively). Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status. IMC J Med Sci 2018; 12(2): 44-49

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“…[242526] Few studies have shown a positive correlation of serum 25(OH)D levels and BMD. [20222327] Vitamin D is a fundamental vitamin to maintain calcium level in the bone by increasing calcium absorption in the intestines, stimulating bone resorption by increasing number of osteoclasts, and maintain level of parathyroid hormone to stabilize serum calcium levels. [23]…”

Section: Discussionmentioning

confidence: 99%

Association between serum 25-hydroxyvitamin D levels and bone mineral density in normal postmenopausal women

2016

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Aim:This study was conducted with the objective of assessing serum 25-hydroxyvitamin D (25(OH)D) in postmenopausal women (PMW), to detect osteopenia or osteoporosis in PMW and to establish a correlation between serum 25(OH)D levels and bone mineral density (BMD).Materials and Methods:A total of 100 healthy PMW were selected, and a prospective observational study was conducted to correlate the BMD with serum 25(OH)D levels. Their laboratory investigations along with serum 25(OH)D levels were done. Their BMD was assessed with dual-energy X-ray absorptiometry at lumbar spine and neck of femur; T-scores were derived. Correlation analysis was done to investigate the relationship between serum 25(OH)D levels and BMD.Results:The proportion of osteoporosis at the hip was 31.9% in deficient group, 16.1% in insufficient, and 18.2% in sufficient group and at lumbar spine, it was 27.7%, 16.1%, and 22.7%, respectively. Forty-seven percent of PMW had deficient (<20 ng/ml) serum 25(OH)D levels and 31% had insufficiency. T-score at hip in deficient group was −2.05 ± 0.25, and in an insufficient group, it was −1.79 ± 0.13; T-score at lumbar spine was −1.92 ± 0.12 and −1.79 ± 0.12, respectively, but both were not statistically significant. Osteoporosis was seen in 24%, osteopenia in 55% at hip level and 23% and 59% respectively at lumbar spine. There was no association between serum 25(OH)D levels and BMD neither at hip nor at lumbar spine (P = 0.51 and P = 0.79 respectively).Conclusion:In this study, among our cohort of patients there was no correlation between serum 25(OH)D levels and BMD. However, Vitamin D deficiency coexists with low BMD. Vitamin D insufficiency is a common risk factor for osteoporosis associated with increased bone remodeling and low bone mass.

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Low vitamin D, and bone mineral density with depressive symptoms burden in menopausal and postmenopausal women

Cited by 17 publications

References 24 publications

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

Association between serum 25-hydroxyvitamin D levels and bone mineral density in normal postmenopausal women

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