Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain Fortification

Kelly, Peter; Shih, Vivian E.; Kistler, J P; Barron, M.; Lee, Hang; Mandell, Roseann; Furie, Karen L.

doi:10.1161/01.str.0000071109.23410.ab

Cited by 92 publications

(72 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A strong association between stroke/TIA and low PLP (defined as levels less than 20 nmol/l) was independent of other well-established vascular risk factors, including total plasma homocysteine concentrations. Furthermore, results from that study identified a possible protective effect for higher PLP concentrations (29) . In the context of the Health Professional Follow-up Study, He et al evaluated dietary intakes of vitamin B 6 together with the intake of other B vitamins by a semiquantitative FFQ (51) in relation to the risk of ischaemic and haemorrhagic stroke (52) .…”

Section: Vitamin B 6 and Strokementioning

confidence: 85%

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

View full text Add to dashboard Cite

The objective of the present review is to highlight the relationship between low vitamin B 6 status and CVD through its link with inflammation. While overt vitamin B 6 deficiency is uncommon in clinical practice, increasing evidence suggests that marginal vitamin B 6 deficiency is rather frequent in a consistent proportion of the population and is related to an increased risk of inflammation-related diseases. Ample evidence substantiates the theory of atherosclerosis as an inflammatory disease, and low plasma vitamin B 6 concentrations have been related to increased CVD risk. Several studies have also shown that low vitamin B 6 status is associated with rheumatoid arthritis and chronic inflammatory bowel diseases, both of which hold an underlying chronic inflammatory condition. Furthermore, the inverse association observed between inflammation markers and vitamin B 6 supports the notion that inflammation may represent the common link between low vitamin B 6 status and CVD risk. In addition to the epidemiological evidence, there are a number of cell culture and animal studies that have suggested several possible mechanisms relating impaired vitamin B 6 status with chronic inflammation. A mild vitamin B 6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy.

show abstract

Section: Vitamin B 6 and Strokementioning

confidence: 85%

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

View full text Add to dashboard Cite

show abstract

“…Our study does not support the hypothesis that vitamin B-6 deficiency impairs PE methylation by altering hepatic SAM and SAH contents. Strong epidemiological associations exist between low vitamin B-6 status and risk of cardiovascular disease, other forms of vascular disease, and stroke (22,33,34,44), although the mechanism is unclear. Epidemiological studies also show associations between low plasma PLP concentration and markers of inflammation (30,31,43).…”

Section: Discussionmentioning

confidence: 99%

Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells

Zhao

Ralat

Silva

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Vitamin B-6 deficiency has been reported to alter n-6 and n-3 fatty acid profiles in plasma and tissue lipids; however, the mechanisms underlying such metabolic changes remain unclear. The objective of this study was to determine the effects of vitamin B-6 restriction on fatty acid profiles and fatty acid synthesis in HepG2 cells. Cells were cultured for 6 wk in media with four different vitamin B-6 concentrations (10, 20, 50, and 2,000 nM added pyridoxal, representing deficient, marginal, adequate, and supraphysiological conditions) that induced a range of steady-state cellular concentrations of pyridoxal phosphate. Total cellular lipid content was greatest in the deficient (10 nM pyridoxal) medium. The percentage of arachidonic acid and the ratio of arachidonic acid to linoleic acid in the total lipid fraction were ∼15% lower in vitamin B-6-restricted cells, which suggests that vitamin B-6 restriction affects n-6 fatty acid interconversions. Metabolic flux studies indicated significantly lower fractional synthesis rate of oleic acid and arachidonic acid at 10, 20, and 50 nM pyridoxal, whereas that of eicosapentaenoic acid was lower in the cells cultured in 10 nM pyridoxal. Additionally, relative mRNA expressions of Δ5 and Δ6 desaturases were 40–50% lower in vitamin B-6-restricted cells. Overall, these findings suggest that vitamin B-6 restriction alters unsaturated fatty acid synthesis, particularly n-6 and n-3 polyunsaturated fatty acid synthesis. These results and observations of changes in human plasma fatty acid profiles caused by vitamin B-6 restriction suggest a mechanism by which vitamin B-6 inadequacy influences the cardiovascular risk.

show abstract

“…In one study high-dose vitamin B 6 therapy was reported to be effective in reducing cardiovascular events in patients with elevated homocysteine levels due to cystathionine B synthase abnormalities; 53 however, such treatment was not effective in reducing elevated homocysteine levels in adults with mild elevations in homocysteine. 54 In a recent case-control study, Kelly and associates 55 found a significantly strong independent association between low levels of vitamin B 6 and stroke or transient ischemic attack but not between elevated homocysteine levels and vascular events.…”

Section: B Vitaminsmentioning

confidence: 97%

Homocysteine and cognitive function in elderly people

García

Zanibbi²

2004

Canadian Medical Association Journal

111

View full text Add to dashboard Cite

DEMENTIA IS HIGHLY PREVALENT AMONG ELDERLY PEOPLE, and projections show that the number of people affected might triple over the next 50 years, mainly because of a large increase in the oldest-old segment of the population. Because of this and the disease's devastating effects, measures for the prevention and early detection of dementia are crucial. Age and years of education are among the most relevant risk factors for dementia, but in recent years the role of homocysteine has also been investigated. Homocysteine is an amino acid produced in the metabolism of methionine, a process dependent on the B vitamins cobalamin, vitamin B 6 and folic acid. There is evidence that increased serum homocysteine levels are associated with declining cognitive function and dementia. We review this evidence in addition to the potential mechanisms through which homocysteine acts on the brain to cause cognitive dysfunction, the metabolism of homocysteine and factors associated with alteration of the normal metabolism.

show abstract

Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain Fortification

Abstract: Low B6 but not tHcy was strongly associated with cerebrovascular disease in this postfortification, folate-replete sample.

Cited by 92 publications

References 10 publications

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells

Homocysteine and cognitive function in elderly people

Contact Info

Product

Resources

About

Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain Fortification

Abstract: Low B6 but not tHcy was strongly associated with cerebrovascular disease in this postfortification, folate-replete sample.

Cited by 92 publications

References 10 publications

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells

Homocysteine and cognitive function in elderly people

Contact Info

Product

Resources

About

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B₆: a challenging link between nutrition and inflammation in CVD