Low use of effective and safe therapies for moderate to severe menopausal symptoms

Worsley, Roisin; Bell, Robin Jean; Gartoulla, Pragya; Davis, Susan Ruth

doi:10.1097/gme.0000000000000495

Cited by 31 publications

(14 citation statements)

References 51 publications

(56 reference statements)

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“…It is also not surprising that the proportion of women reporting MHT exposure was higher in the retrospective cohort as the question about MHT use at the time of that study included MHT use within the last 6 months, whereas the question in the time of the prospective study was about current use. The % of women reporting current use in the prospective group (11.2) fits with recent large surveys of MHT use among Australian women aged 40–64 and 65–79 …”

Section: Discussionsupporting

confidence: 83%

Using an automated measure of breast density to explore the association between ethnicity and mammographic density in Australian women

et al. 2019

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Introduction:The aim of this study was to investigate mammographic density in a sample of Victorian women and explore a possible association between mammographic density and ethnicity. Methods: Categories of mammographic density, using Volpara Density Grade, were reported using two editions of Volpara automated software in a data set of women attending two Victorian sites for mammographic screening. The variables available for analysis were age, self-reported exposure to menopausal hormone therapy (MHT) and ethnicity based on country of birth. Results: Data from 16,943 women were available for analysis. Using the VDG 4th edition, 40% of women were classified in the higher two categories (42% for the 5th edition) and 76.9% of women were in the same VDG category using both systems. In the sample, 87.7% of women were in the age range currently invited for screening in Victoria (50-74 years). Of the total group, 82.5% could be classified on the basis of country of birth. In multivariable logistic regression analyses examining factors associated with higher VDG, age (protective), use of MHT (risk factor) and being born in a country with predominantly Asian ancestry (risk factor) were all statistically significant at P < 0.001 for both editions irrespective of whether the reference category was the lowest two or three VDG categories. Conclusions: Mammographic density as assessed by VDG was positively associated with ever exposure to MHT and inversely associated with age. Being born in a country with predominantly Asian ancestry was associated with higher VDG when controlled for age and MHT exposure.

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Section: Discussionsupporting

confidence: 83%

Using an automated measure of breast density to explore the association between ethnicity and mammographic density in Australian women

et al. 2019

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“…This review highlights the high prevalence of VMS among Iranian postmenopausal women in both population and clinic-based studies. These findings are in line with findings from Western countries with a high prevalence report for VMS (2,(26)(27)(28)(29) and are in contrast with findings from south Asian countries such as Indonesia, Korea, China, Japan and Hong Kong, where there was a lower prevalence of VMS compared to other menopausal symptoms such as physical and psychological symptoms (30). Our findings confirm ethnic variation in reporting VMS by women from different societies (1).…”

Section: Discussioncontrasting

confidence: 53%

A Systematic Review of Prevalence of Vasomotor and Sexual Symptoms Among Iranian Middle-Aged Women

Masoumi

Azizi

Atarod

et al. 2017

Iran Red Crescent Med J

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Context: The aim of this study was to systematically review published articles reporting on the prevalence of vasomotor and sexual symptoms in Iranian women.Evidence Acquisition: Five databases including MEDLINE, PsycINFO, CINAHL, SCOPUS and Google scholar, as well as four Iranian databases including SID, Iranmedex, IranDoc and Magiran were searched during July 2016 to retrieve studies reporting on the prevalence of vasomotor and sexual symptoms in Iranian middle-aged women. Risk of bias was assessed using a standard risk of bias tool.Results: Twelve independent studies met our inclusion criteria and provided data for this review. The prevalence of vasomotor and sexual symptoms was high although the ranges were wide. This might be due to utilization of different study designs, methods of recruitment, instruments, and the time frame over which symptoms were assessed. There was a lack of information in most studies on the severity of symptoms as an important determining factor for clinical use. In addition, distress associated with sexual symptoms has not been assessed by any study. High risk of bias was observed for the eleven studies for both external and internal validity.Conclusions: High quality research is needed to establish the true portray for the prevalence and severity of vasomotor and sexual symptoms associated with distress in Iranian women.

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“…It is thought that oestrogen may play a role in mood and cognitive function through modulatory effects on serotonin and noradrenaline neurotransmission (Soares, 2014). Both hysterectomy and bilateral oophorectomy have been associated with changes in blood supply to the ovaries and hormone levels as a result of the surgery (Nahas et al 2003; Xiangying et al 2006; Parker et al 2009) and as a consequence, a higher proportion of women who have had a hysterectomy/oophorectomy also use menopausal hormone therapy (MHT) than women without a hysterectomy (Blumel et al 2014; Worsley et al 2016). We therefore were also interested in exploring whether hormone use throughout midlife modifies the relationship between depressive symptoms and hysterectomy status.…”

Section: Introductionmentioning

confidence: 99%

Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women's Health

Wilson

Pandeya

Byles

et al. 2017

Epidemiol Psychiatr Sci

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Low use of effective and safe therapies for moderate to severe menopausal symptoms

Abstract: Most women with severe menopausal symptoms remain untreated despite the availability of safe nonhormone therapies and safer low-dose transdermal hormone therapies. Vaginal estrogen therapy is underprescribed.

Cited by 31 publications

References 51 publications

Using an automated measure of breast density to explore the association between ethnicity and mammographic density in Australian women

Using an automated measure of breast density to explore the association between ethnicity and mammographic density in Australian women

A Systematic Review of Prevalence of Vasomotor and Sexual Symptoms Among Iranian Middle-Aged Women

Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women's Health

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