Low Survival Rates of Oral and Oropharyngeal Squamous Cell Carcinoma

Campion, Anna Carolina Omena Vasconcellos Le; Ribeiro, Camila Maria Beder; Luiz, Ronir Raggio; Júnior, Francisco Feliciano da Silva; Barros, Herbert Charles Silva; Santos, Karine de Cássia Batista dos; Ferreira, Stefânia Jeronimo; Gonçalves, Lúcio Souza; Ferreira, Sônia Maria Soares

doi:10.1155/2017/5815493

Cited by 87 publications

(97 citation statements)

References 30 publications

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“…In Brazil, Santa Catarina reported a 5-year OS for OC and pharyngeal cancer of 33.3% (12). In Maceio, northeast of Brazil, the 5-year OS for oropharyngeal cancer was 27.8% (12,13). In Santa Maria, south of Brazil, the 5-year OS for OC and oropharyngeal cancer was 42%; however, patients with oropharyngeal cancer had the worst survival rates (14).…”

Section: ' Introductionmentioning

confidence: 99%

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Kowalski¹,

Oliveira²,

López³

et al. 2020

Clinics

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OBJECTIVE:We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS:The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models. RESULTS: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year. CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.

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Section: ' Introductionmentioning

confidence: 99%

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Kowalski¹,

Oliveira²,

López³

et al. 2020

Clinics

View full text Add to dashboard Cite

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“…2 Despite an improvement of treatment modalities, the overall 5-year survival rate for OSCC is about 50%. 3 One of the most used means to predict the tumor behavior is the tumor-node-metastasis (TNM) staging system. Anyway, patients classified under the same TNM stage undergo the same treatment but show differences prognosis.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma

Caponio

Troiano

Botti

et al. 2018

J Oral Pathology Medicine

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Background ADAR1 is an enzymatic protein, which catalyzes a RNA editing reaction by converting Adenosine to Inosine, and its expression has been found to be dysregulated in many cancer types. The aim of this study was to analyze the expression of ADAR1 in oral squamous cells carcinoma. Methods In order to analyze the ADAR1 mRNA expression, data from The Cancer Genome Atlas (TCGA) database were downloaded and analyzed. In addition, immunohistochemistry analysis was performed on an institutional database including 46 samples of oral squamous cell carcinoma in a tissue microarray (TMA). Results No statistically significant correlation linked the mRNA ADAR1 expression to any clinic‐pathological variables in the TCGA database. Immunohistochemistry analysis of ADAR1 showed different expressions between normal mucosa and tumor tissue. Focusing on the subcellular localization, the nuclear expression of ADAR1 correlated with higher grading of differentiation (ρ = 0.442; P‐value = 0.002); the general expression of ADAR1 either in cytoplasm or in nuclei, correlated with the Gender of patients (Cytoplasm expression: ρ = −0.295; P‐value = 0.049; while for nuclear expression: ρ = +0.374; P = 0.011); cytosol expression resulted to be an independent protective prognostic factor (HR = 0.047; C.I. 95% 0.007‐0.321; P‐value = 0.002). Conclusion Higher expression of ADAR1 into the cytoplasm resulted to be an independent prognostic factor. In order to understand ADAR1 role in cancer, further studies should be performed, in bigger cohort and under a bio‐molecular point of view.

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“…Local recurrence and metastasis occur frequently in OSCC in spite of the significant advancement in diagnosis and treatment approach, leading to unsatisfactory survival and poor prognosis [23]. Thus, new treatment modalities and sensitive molecular biomarkers are required that can lower OSCC mortality.…”

Section: Discussionmentioning

confidence: 99%

Cancerous Inhibitor of Protein Phosphatase 2A as a Molecular Marker for Aggressiveness and Survival in Oral Squamous Cell Carcinoma

et al. 2020

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Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as one of the most commonly altered proteins in human cancers. It blocks the tumor-suppressive action of protein phosphatase 2A (PP2A) complex and enhances malignancy. Thirty-five patients with squamous cell carcinoma of the oral cavity underwent surgical resection of the tumor. CIP2A was assessed by quantitative real-time PCR in the resected tumor tissues and in their adjacent normal tissues. CIP2A was found to be overexpressed in all oral squamous cell carcinoma (OSCC) specimens in comparison to their surrounding normal tissue. CIP2A overexpression was statistically correlated with poor prognostic feature of the tumor. Thus, a high expression level of CIP2A was associated with shorter survival. In conclusion, CIP2A is upregulated in OSCC, and its overexpression is correlated with aggressiveness of the tumor and poor outcome and survival. It may serve as a prognostic marker of OSCC.

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Low Survival Rates of Oral and Oropharyngeal Squamous Cell Carcinoma

Cited by 87 publications

References 30 publications

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma

Cancerous Inhibitor of Protein Phosphatase 2A as a Molecular Marker for Aggressiveness and Survival in Oral Squamous Cell Carcinoma

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