Low Serum Total Bilirubin Concentration was Associated with Increased High Sensitive C Reactive Protein Level in Patients with Impaired Glucose Tolerance and Type 2 Diabetes Mellitus Subjects

Ji, Zheng; Wu, Yonghua; Li, Zhenrong; Wang, Haining; Xiao, Wenhua; Shi, Yanyan; Wang, Tiancheng

doi:10.7754/clin.lab.2015.150936

Cited by 9 publications

(8 citation statements)

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“…During surgery, CPB-induced coagulopathy, platelet activation and dysfunction and promoted coagulation factor consumption and excessive fibrinolysis [25,26]. Therefore, patients undergoing surgery for AAD bleed excessively and require blood products and transfusions, which is the primary cause of surgical-mortality [27]. In our study, a large number of blood transfusions (≥2000 ml) during surgery is also a risk factor for postoperative one-year mortality.…”

Section: Discussionmentioning

confidence: 64%

Perioperative risk factors predict one-year mortality in patients with acute type-A aortic dissection

Yang

Xue

et al. 2020

J Cardiothorac Surg

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Objective The goal of this study was to analyze perioperative risk factors to predict one- year mortality after operation for acute type A aortic dissection (AAD). Methods A total of 121 consecutive patients undergoing Stanford type A AAD surgery in Beijing Anzhen Hospital were enrolled. Preoperative clinical and laboratory data from patients were collected. Results Multivariable Cox regression analysis showed that significant factors associated with increased one-year mortality were elder age (year) (hazard ratio (HR) 1.0985; 95% confidence interval (CI) 1.0334–1.1677), intraoperative blood transfusion ≥2000 mL (HR 8.8081; 95% CI 2.3319–33.2709), a higher level of serum creatinine (μmol/L) at postoperative one day (HR 1.0122; 95% CI 1.0035–1.0190) and oxygenation index (OI) < 200 (mmHg) at the end of surgery (HR 5.7575; 95% CI 1.1695–28.3458). Conclusion In this study, perioperative risk factors to predict one-year prognosis are age, intraoperative blood transfusion ≥2000 mL, postoperative OI < 200 mmHg and level of postoperative serum creatinine. The results aid in the comprehension of surgical outcomes and assist in the optimization of treatment strategies for those with perioperative risk factors to decrease one-year mortality.

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Section: Discussionmentioning

confidence: 64%

Perioperative risk factors predict one-year mortality in patients with acute type-A aortic dissection

Yang

Xue

et al. 2020

J Cardiothorac Surg

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“…Bilirubin is one of the end products of heme catabolism and has been shown to have antioxidant and anti-inflammatory effects [ 6 ]. Due to the effects of heme oxygenase (HO), which contain two forms: HO-1 and HO-2, cyclic tetrapyrrole heme is divided into biliverdin, carbon monoxide (CO), and ferrous iron (Fe 2+ ).…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population

Zhang

Jin

et al. 2018

International Journal of Endocrinology

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Objective To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59.55 ± 10.63 years, and 43.5% of the subjects were women. The mean of DM duration was 11.01 ± 7.35 years. STBC were negatively correlated with DM duration, urea nitrogen, serum creatinine, uric acid, and urine microalbumin. After adjusting for confounding factors, as a continuous variable, STBC was inversely associated with the risk of DR in total subjects (OR: 0.95, 95% CI: 0.93–0.99). When STBC was used as a tertiary variable, compared with the first tertile, the OR in the third tertile was 0.37 (95% CI: 0.22–0.64) in total subjects. Conclusion Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR.

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“…This result suggest that a significant association between metabolic syndrome component with hs-CRP. It was also reported that depletion of serum total biliruvin (TB) is associated with the enhancement of inflammatory responses and oxidative stresses in T2DM individuals 58 which put severe strain on pancreatic β-cells 53 . The reason of pancreatic β-cells become less responsive is due to the down-regulation of glucose-sensing mechanism in the β-cells (glucotoxicity) leading to diminished insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

“…The reason of pancreatic β-cells become less responsive is due to the down-regulation of glucose-sensing mechanism in the β-cells (glucotoxicity) leading to diminished insulin secretion. Lower TB may also be the result of impaired liver function 58 . A certain degree of impaired liver function may develop insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes

Bhattacharya

Khan²,

Ghosh

et al. 2017

Sci Rep

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Diabetes is now epidemic worldwide. Several hundred-million peoples are presently suffering from this disease with other secondary-disorders. Stress, hypertension, sedentary life-style, carbohydrate/lipid metabolic-disorders due to genetic or environmental factors attributes to type-1 and/or type-2 diabetes. Present investigation demonstrates that stress-induced protein dermcidin isoform-2 (DCN-2) which appears in the serum of diabetic-patients play a key-role in this disease pathogenesis/severity. DCN-2 suppresses insulin production-release from liver/pancreas. It also increases the insulin-resistance. Stress-induction at the onset/progression of this disease is noticed as the high-level of lipid peroxides/low-level of free-thiols in association with increase of inflammatory-markers c-reactive protein and TNF-α. DCN-2 induced decrease in the synthesis of glucose-activated nitric oxide synthase (GANOS) and lower production of NO in liver has been shown here where NO is demonstrated to lower the expression of glucose trabsporter-4 (GLUT-4) and its translocation on liver membrane surface. This finally impairs glucose transport to organs from the extracellular fluid. Low level of glucose uptake further decreases glucose-induced insulin synthesis. The central role of DCN-2 has been demonstrated in type-1/type-2 diabetic individuals, in rodent hepatocytes and pancreatic-cell, tissue-slices, in-vitro and in-vivo experimental model. It can be concluded that stress-induced decrease in insulin synthesis/function, glucose transport is an interactive consequence of oxidative threats and inflammatory events.

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Low Serum Total Bilirubin Concentration was Associated with Increased High Sensitive C Reactive Protein Level in Patients with Impaired Glucose Tolerance and Type 2 Diabetes Mellitus Subjects

Cited by 9 publications

References 0 publications

Perioperative risk factors predict one-year mortality in patients with acute type-A aortic dissection

Perioperative risk factors predict one-year mortality in patients with acute type-A aortic dissection

Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population

The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes

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