Low serum selenium concentrations are associated with poor grip strength among older women living in the community

Beck, Justine; Ferrucci, Luigi; Sun, Kai; Walston, Jeremy D.; Fried, Linda P.; Varadhan, Ravi; Guralnik, Jack M.; Semba, Richard D.

doi:10.1002/biof.5520290104

Cited by 57 publications

(34 citation statements)

References 31 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, an association between low intake of carotenoids, vitamin E and C on the one hand and reduced strength [43], reduced performance [43] and frailty [7] on the other hand, was described. Low serum levels of carotenoids, vitamin E and selenium were found to be associated with reduced muscle strength [43][44][45], reduced physical performance [46] and frailty [47]. Longitudinally a decline in physical performance [36,46] and an increased risk of becoming frail [48] in the course of 3 or 6 years were observed in elderly persons with low antioxidant serum levels.…”

Section: Antioxidants and V3-fatty Acidsmentioning

confidence: 96%

The role of nutrition in the prevention of sarcopenia

Volkert

2011

Wien Med Wochenschr

View full text Add to dashboard Cite

Nutrition is regarded as one important contributing factors in the complex etiology of sarcopenia. Associations between several nutritional factors and muscle mass, strength, function and physical performance were reported in a growing number of studies in recent years. Accordingly, the avoidance of weight loss is crucial to prevent the concomitant loss of muscle mass. Adequate amounts of high-quality protein are important for optimal stimulation of muscle protein synthesis. Vitamin D, antioxidants and ω 3-polyunsaturated fatty acids may also contribute to the preservation of muscle function. In order to ensure adequate intake in all elderly, nutritional problems like loss of appetite and weight loss should be recognized early by routine screening for malnutrition in the elderly. Underlying causes need to be identified and subsequently corrected. The importance of physical activity, specifically resistance training, is emphasized, not only in order to facilitate muscle protein anabolism but also to increase energy expenditure, appetite and food intake in elderly people at risk of malnutrition.

show abstract

Section: Antioxidants and V3-fatty Acidsmentioning

confidence: 96%

The role of nutrition in the prevention of sarcopenia

Volkert

2011

Wien Med Wochenschr

View full text Add to dashboard Cite

show abstract

“…At baseline, participants in the lowest versus the highest quartile of plasma selenium were at higher risk of poor hip, knee and grip strength after adjustment for age, sex education, total energy intake BMI, and chronic disease [25]. Similarly, among disabled women in the WHAS, after adjusting for age, race, BMI, MMSE, current smoking, hypertension, congestive heart failure and depression, higher serum selenium was associated with higher grip strength [26]. …”

Section: Nutrient Biomarkersmentioning

confidence: 99%

Nutritional determinants of mobility

Milaneschi

Tanaka

Ferrucci

2010

Current Opinion in Clinical Nutrition and Metabolic Care

Self Cite

View full text Add to dashboard Cite

Purpose of review-In many countries, persons over 65 is one of the fastest growing segment of the population. Mobility disability is one of the major risk factors for morbidity and mortality in this age group. There is increasing evidence that improved nutrition can reduce the risk of developing disability in older age. This review summarizes the recent literature showing the associations between different nutrients and mobility-related outcomes in older adults.Recent findings-Recent studies suggested an association between low intake and low serum concentrations of micronutrients, such as antioxidants and vitamins, with measures of physical performance, muscle strength and disability in older adults.Summary-The role of low micronutrients as cross-sectional and longitudinal correlates of mobility disability is consistent with a growing number of studies showing that a diet rich in fruits and vegetables, such as the Mediterranean diet, has a beneficial role in healthy aging.

show abstract

“…Malondialdehyde (MDA) is one of frequently used markers of lipid peroxidation [5,[10][11][12][13]. Superoxide dismutase-catalase enzyme complex are the first line of cellular defense against free radical toxicity [14]. Exposure of cells to oxidative stress can in-duce this complex.…”

Section: Introductionmentioning

confidence: 99%

“…Selenium, a trace element, has antioxidant and neuroprotective effects [14]. Selenium protects DNA, lipids and proteins against free radicals [14]. Selenium reduces lipoproxidase and hydroxides through a similar activity of glutathione peroxidase [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Zendedel

Delavari

Ahmadvand

et al. 2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Selenium is an antioxidant trace element that is capable protects various tissues against damage induced by ischemiareperfusion injury. Objectives: This study examines the selenium effect on antioxidant activity and recovery from sciatic nerve ischemia-reperfusion in adult rats. Materials and Methods:In this experimental study, 80 adult male Wistar rats weighing 250 -300 g were used. They were divided into ten groups (n = 8 per group). The first group received sham surgery only. The second group received 0.2 mg/kg selenium without ischemiareperfusion surgery and eight remaining groups were divided to four control groups and four experimental groups which the latter groups received 0.2 mg/kg selenium. All ischemia groups were rendered in ischemic for 3 hours and reperfused for various times of 3, 7, 14 and 28 days. Half of the groups had experimental selenium (0.2 mg/kg) intraperitoneal injection treatment immediately after ischemia. According to a schedule for each group of rats bled and then centrifuged, and serum was prepared for assessment of activity levels of glutathione peroxidase (GPX), catalase (CAT), nitric oxide (NO), paraoxonase (POX), and malondialdehyde (MDA). Results: Comparison of the serum GPX, CAT, NO, POX, and MDA levels in the groups that received selenium with corresponding control group showed that selenium can increase plasma activity levels of GPX, POX and decrease activity levels of NO. Conclusions: Selenium with decreased activity levels of NO and increased activity GPX and POX can decrease ischemia-reperfusion injury in lower limb especially sciatic nerve.

show abstract

Low serum selenium concentrations are associated with poor grip strength among older women living in the community

Cited by 57 publications

References 31 publications

The role of nutrition in the prevention of sarcopenia

The role of nutrition in the prevention of sarcopenia

Nutritional determinants of mobility

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Contact Info

Product

Resources

About