Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus

Jia, Xiaoxia; An, Yingli; Xu, Yuechao; Yang, Yuxian; Liu, Chang; Zhao, Dong; Ke, Jing

doi:10.1530/ec-21-0449

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Despite most studies having confirmed a negative association between VFA and OC and β-CTX in postmenopausal women ( 20 , 32 ), fewer studies have explained the underlying relationships between perirenal fat and BTMs. A recent study that enrolled 234 T2DM patients reported that PrFT measured by ultrasound is negatively correlated with β-CTX ( 33 ). In the present study, the results are consistent with the above study; PrFT was negatively correlated with β-CTX after adjusting for potential confounding factors.…”

Section: Discussionmentioning

confidence: 99%

Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Wang¹,

Huang²,

Tang³

et al. 2022

Front. Endocrinol.

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ObjectivesEmerging evidence demonstrated that perirenal fat may modulate bone metabolism through several pathological pathways. This study was aimed to assess the associations between perirenal fat thickness (PrFT) and bone turnover markers (BTMs) and bone mineral density (BMD) in postmenopausal women with type 2 diabetes mellitus (T2DM) and further explore the correlation between PrFT and osteoporosis.MethodsIn this cross-sectional study, a total of 626 participants with complete data were enrolled in this study. Demographic and anthropometric information was collected. Biochemical parameters and BTMs were determined. PrFT and BMD were measured by computed tomography and dual-energy x-ray absorptiometry, respectively. Correlation analysis and regression models were used to assess the associations between PrFT and BTMs and BMD. The multiple binomial logistic regression model was used to estimate the independent variables of PrFT for osteoporosis.ResultsOverall, the prevalence of osteoporosis was 38.7%. PrFT was negatively correlated with β-cross-linked C-telopeptide of type I collagen (β-CTX) (r = -0.216,< 0.001), L1–L4 BMD (r = -0.351, < 0.001), and T-score (r = -0.396, < 0.001). PrFT also remained significantly correlated with β-CTX (β = -0.291, P< 0.001), L1–L4 BMD (β = -0.109, P= 0.027), and L1–L4 T-score (β = -0.149, P= 0.001) after adjustment for other confounding factors. Furthermore, PrFT was also independently associated with osteoporosis after adjustment for other confounding factors; the OR (95% CI) was 1.13 (1.04–1.23). PrFT also seems to have a relatively good identifying value for osteoporosis. The area under the curve (AUC) value of PrFT in identifying osteoporosis was 0.766 (95% CI: 0.705–0.826, P < 0.001). The optimal cutoff value of PrFT was 15.2 mm (sensitivity: 72.5%, specificity: 79.8%).ConclusionsPrFT was significantly associated with β-CTX, BMD, and osteoporosis. These findings indicate that perirenal fat may play an important role in bone metabolism.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier (ChiCTR2100052032).

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Section: Discussionmentioning

confidence: 99%

Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Wang¹,

Huang²,

Tang³

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

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“…(4). Obesity is considered an abnormal or excessive fat accumulation, which is known as a common osteoporosis risk factor and (T2DM) (5). Body weight and body mass index are thought to be strong predictors of osteoporotic fractures.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

ABED¹,

Rasheed²,

G.Hussein³

2022

JFacMedBagdad

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Background: Type 2 diabetes negatively affects the biochemical parameters of bone turnover more than obesity and is associated with an increased risk of osteoporosis and fragility fractures. Obesity and type 2 diabetes (T2DM) are linked to increased fracturing risk; however, the effect of obesity on diabetes-related bone deficit is unknown. Objective: The goal of this research is to compare the indications, bone density, and bone turnover in T2DM men and a control group, and to investigate the effect of body mass index on bone turnover levels. Subjects, Material and Method: This case-control study was conducted on 120 men whose ages were from 40 - 69 years. They were grouped into two categories: T2DM (n=80) and healthy control (n=40). Serum samples from both groups were analyzed for blood glucose, Calcium and Albumin, by using (Cobas c111), PTH by (Cobas e 411), P1NP and CTX-1 levels in the serum using ELISA kits. Participants underwent (DEXA) measuring Bone Mass Density (BMD) at the lumbar spine. Results: The control (obese and non-obese) participants had statistically significant higher levels of CTX-1 and P1NP than the patients (obese and non-obese) (P-value = 0.000). There was no significant differences in Spine BMD, T-score (p-value = 0.27 and 0.37 respectively). Conclusion: Men with T2DM had a low bone turnover level and deteriorated bone quality compared to controls. The obese healthy controls can maintain healthy bone metabolism if T2DM is prevented.

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Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus

Cited by 2 publications

References 35 publications

Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

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