Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Abstract

ObjectivesEmerging evidence demonstrated that perirenal fat may modulate bone metabolism through several pathological pathways. This study was aimed to assess the associations between perirenal fat thickness (PrFT) and bone turnover markers (BTMs) and bone mineral density (BMD) in postmenopausal women with type 2 diabetes mellitus (T2DM) and further explore the correlation between PrFT and osteoporosis.MethodsIn this cross-sectional study, a total of 626 participants with complete data were enrolled in this study. Demographic and anthropometric information was collected. Biochemical parameters and BTMs were determined. PrFT and BMD were measured by computed tomography and dual-energy x-ray absorptiometry, respectively. Correlation analysis and regression models were used to assess the associations between PrFT and BTMs and BMD. The multiple binomial logistic regression model was used to estimate the independent variables of PrFT for osteoporosis.ResultsOverall, the prevalence of osteoporosis was 38.7%. PrFT was negatively correlated with β-cross-linked C-telopeptide of type I collagen (β-CTX) (r = -0.216,< 0.001), L1–L4 BMD (r = -0.351, < 0.001), and T-score (r = -0.396, < 0.001). PrFT also remained significantly correlated with β-CTX (β = -0.291, P< 0.001), L1–L4 BMD (β = -0.109, P= 0.027), and L1–L4 T-score (β = -0.149, P= 0.001) after adjustment for other confounding factors. Furthermore, PrFT was also independently associated with osteoporosis after adjustment for other confounding factors; the OR (95% CI) was 1.13 (1.04–1.23). PrFT also seems to have a relatively good identifying value for osteoporosis. The area under the curve (AUC) value of PrFT in identifying osteoporosis was 0.766 (95% CI: 0.705–0.826, P < 0.001). The optimal cutoff value of PrFT was 15.2 mm (sensitivity: 72.5%, specificity: 79.8%).ConclusionsPrFT was significantly associated with β-CTX, BMD, and osteoporosis. These findings indicate that perirenal fat may play an important role in bone metabolism.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier (ChiCTR2100052032).

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“…The cross‐sectional study showed that APOA1 positively associated with osteocalcin (OC), L1‐L4 BMD, and T‐score in Chinese postmenopausal women. Additionally, it has been demonstrated that APOA1 is independently linked to a decreased risk of osteoporosis (Wang et al., 2023). The results showed that the risk of osteoporosis significantly decreased with the increase of APOA1.…”

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“…Adiponectin also exhibits anti-osteoporotic activity, promoting differentiation and mineralization of osteoblasts and inhibiting the secretion of OPG [100]. Adiponectin stimulates the expression of osteocalcin, which acts as a hormone regulating glucose metabolism and fat mass [72,73,87,[101][102][103][104][105][106]. The potential effect of adiponectin on osteoblasts and osteoclasts, and therefore on bone remodeling, may be mediated through the endocrine system and may influence lipid metabolism.…”