Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study

Holvik, Kristin; Ahmed, Luai A.; Forsmo, Siri; Gjesdal, Clara Gram; Grimnes, Guri; Samuelsen, Sven Ove; Schei, Berit; Blomhoff, Rune; Tell, Grethe S.; Meyer, Haakon E

doi:10.1210/jc.2013-1468

Cited by 72 publications

(70 citation statements)

References 37 publications

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“…Vitamin D deficiency is known to be related with increased risk of fracture (Holvik et al, 2013) and positively associated with low BMD (Sadat-Ali et al, 2011). However, we have found a significant negative association between 25-OH D levels and total proximal femur BMD, but not between lumbar spine BMD and 25-OH D. The mechanism of this phenomenon might be explained by higher weight of diabetic patients, which causes the greater skeletal mechanical loading resulting in an increase in total proximal femur BMD.…”

Section: )contrasting

confidence: 63%

High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes Mellitus

et al. 2016

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Abstract:The link between vitamin D and type 2 diabetes mellitus (T2DM) is intensively studied. This study aims to define the serum concentration of 25-hydroxyvitamin D (25-OH D) and to investigate the relationship between 25-OH D status, glycated hemoglobin (HbA1c) and body composition in postmenopausal women with T2DM and in non-diabetic controls. In this crosssectional study, 75 women with T2DM and 32 control subjects were selected. Serum 25-OH D, intact parathyroid hormone (PTH), calcium, fasting glucose and HbA1c, were measured. The mean 25-OH D level was 21.4 ± 11.4 ng/ml (range 4.1-50.7 ng/ml) in diabetic women and 30.3 ± 9.4 ng/ml (range 10.8-54.2 ng/ml) in control group (p<0.001). The prevalence of hypovitaminosis D (< 30 ng/ml) was higher in vitamin D 3 non-supplemented T2DM women (89% vs. 63% controls); the difference diminished in vitamin D 3 (500-1000 IU per day) supplemented subgroups (45% diabetics vs. 42% controls). In T2DM women, 25-OH D levels were not associated to HbA1c, duration of diabetes, fasting glucose and PTH levels, however, 25-OH D levels negatively associated with body mass index (p=0.011), total body fat mass (p=0.005) and total body lean mass (p=0.004). 6)Prague Medical Report / Vol. 117 (2016) No. 1, p. 5-17 of hypovitaminosis D is higher in non-supplemented postmenopausal women with T2DM than in non-diabetic controls (89% vs. 63%). Obesity is a risk factor for vitamin D insufficiency in T2DM postmenopausal women. Further studies evaluating relationships between fat, muscle, bone and vitamin D metabolism in T2DM patients are warranted.

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Section: )contrasting

confidence: 63%

High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes Mellitus

et al. 2016

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“…Similarly to the results of other authors, 25-hydroxyvitamin D was lower in the subjects reporting hip fractures (14). On the other hand, the unadjusted odds ratio for a hip fracture was not significantly increased for any of the two factors (low vitamin D or nursing home residency) as predictors.…”

Section: Discussionsupporting

confidence: 85%

“…Factors that determine the latter are malnutrition, decreased mobility and sun exposure, as well as the physiologic changes in vitamin D synthesis with ageing. Low vitamin D levels have been associated with increased hip fractures with institutionalized subjects being the most affected (14). Moreover, the authors of a recent analysis reached the conclusion that the institutionalized elderly are the group most likely to benefit from systemic vitamin D supplementation (15).…”

Section: Introductionmentioning

confidence: 99%

Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly

Shinkov

Borissovа

Dakovska

et al. 2016

Arch. Endocrinol. Metab.

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Objective: To compare the prevalence of vitamin D deficiency and fracture history in nursing home residents and community-dwelling elderly subjects and to explore the association of vitamin D levels with various characteristics. Materials and methods: Sixty-six nursing home residents and 139 community-dwelling elderly subjects participated. Marital status, medical history, medication including vitamin D supplements, smoking, past fractures were assessed. Weight and height were measured and body mass index calculated. Serum 25-hydroxyvitamin D (25-OHD), PTH, Ca, phosphate, creatinine and eGFR were determined. Results: In the nursing home residents 25-OHD was lower

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“…10 In the National Health and Nutrition Examination Survey, bone mineral density increased about 5% when serum 25(OH)D increased from 20-80 nmol l 11 Vitamin D deficiency was associated with hip fractures and other fractures in several epidemiological studies. [1][2][3] Vitamin D deficiency may cause falls, as shown in epidemiological studies. 12 Probably muscle weakness and postural instability are involved.…”

Section: Rationalementioning

confidence: 94%

“…[1][2][3] This association could be coincidental, as older persons get frail, and frail older persons are at high risk of fracture and vitamin D deficiency because they are less active and do not come outside in the sunshine. 1 However, in one of the studies, adjustment for physical activity levels did not change the results.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D supplements with or without calcium to prevent fractures

2014

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Vitamin D deficiency is associated with fractures. This relationship is biologically plausible. The results of 19 randomized clinical trials with vitamin D with or without calcium show varying results: a decreased fracture incidence in 7, neutral in 10 trials, whereas 2 trials with a high dose of vitamin D once per year showed an increased fracture incidence. In three out of four well-powered trials that used recommended doses of vitamin D 700-1000 IU per day, vitamin D supplementation did not significantly influence fracture risk. In one of these trials, a statistically significant fracture reduction was observed in nursing home residents having severe vitamin D deficiency, low calcium intake and good compliance. Thirteen meta-analyses were done, and 11 of these showed a significantly decreased fracture incidence in the supplemented groups. Vitamin D alone was not effective, studies combining vitamin D and calcium showed inconsistent results. Analyses for vertebral fractures were negative in all cases. In conclusion, a vitamin D supplement of 800 IU per day in combination with calcium may decrease the incidence of non-vertebral fractures, especially in persons in the older age groups having low-baseline vitamin D status and low calcium intake and showing good compliance.

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Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study

Cited by 72 publications

References 37 publications

High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes Mellitus

High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes Mellitus

Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly

Vitamin D supplements with or without calcium to prevent fractures

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