Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly

Shinkov, Alexander; Borissovа, Anna-Maria; Dakovska, Lilia; Vlahov, Jordan; Kassabova, Lidia; Svinarov, Dobrin; Krivoshiev, S

doi:10.1590/2359-3997000000109

Cited by 14 publications

(6 citation statements)

References 31 publications

(38 reference statements)

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“…[ 48 , 54 ]. Associations between the independent variables and 25(OH)D were expected, according to previous research in middle aged and older populations, for: age [ 49 , 54 ], household income [ 69 ], education [ 49 ], residence [ 70 , 71 ], alcoholic beverages consumption [ 53 , 72 ] physical activity [ 55 , 73 ] self-perceived health [ 54 ], supplement intake [ 55 , 74 ] and BMI [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 93%

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

et al. 2017

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BackgroundThe older population is a risk group for hypovitaminosis D. The Ultraviolet Index (UVI) can be an indicator of potential for cutaneous synthesis of vitamin D but physiological and other environmental factors also influence vitamin D synthesis and status. Knowledge about vitamin D status in Portuguese older adults is limited. This study aims to explore the association between Ultraviolet Index and serum 25-hidroxyvitamin D3 [25(OH)D] levels accounting for other potential influential factors.MethodsA cross-sectional study was conducted between December 2015 and June 2016, in 1497 Portuguese older adults (≥ 65 years) within Nutrition UP 65 project. For each participant, serum 25(OH)D was determined and the mean UVI (mUVI) in the respective residence district was calculated for the previous 30 days. Stepwise linear regression analyses were conducted for the following periods of blood collection: between December and June, December and March and April and June. Standardized regression coefficients (Sβ) and 95% confidence intervals were calculated.ResultsThe median 25(OH)D concentration was 35.9 nmol/L. The UVI was independently and positively associated with 25(OH)D in the models for December–June (Sβ = 0.244, 95% CI: 0.198; 0.291, P < 0.001) and April–June (Sβ = 0.295, 95% CI: 0.299; 0.362, P < 0.001) and independently and negatively associated in December–March period (Sβ = −0.149, 95% CI: -0.211; −0.087, P < 0.001).ConclusionsIn this sample with high vitamin D deficiency frequency, the UVI was a predictor of 25(OH)D levels but the direction of the association varied according to the blood collection period. Our results suggest that accounting for the time of year in future research regarding vitamin status and related public health recommendations may be relevant.Electronic supplementary materialThe online version of this article (10.1186/s12877-017-0644-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 93%

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

et al. 2017

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“…While lower 25-[OH]D levels in institutionalized older persons were associated with hip fractures, falls alone were hardly associated to vitamin D status [ 80 ]. Interestingly, elevated parathyroid hormone (PTH) was inversely correlated with vitamin D status and was the only predictor of hip fractures [ 81 ]. Additionally, accumulating evidence suggests vitamin D deficiency is associated with sarcopenia in elderly women [ 82 ].…”

Section: Resultsmentioning

confidence: 99%

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

2018

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Purpose of ReviewThis review broadly discusses the consequences of inadequate consumption, by deficit or excess, of selected micronutrients on the quality of life and morbidity during aging, specifically considering increases in life expectancy and the costs of care in the older persons.Recent FindingsA literature review of the periods 2012 to 2018, focusing on vitamins A, B12, and D, calcium, iron and folate, was completed as these micronutrients are found to significantly affect the aging process. Causation and application of these micronutrients to disorders related to aging are controversial and mixed. This review highlights research needs and controversial points on the role of these micronutrients.SummaryMicronutrient deficiencies are a common and avoidable contributor to decreased quality of life and healthcare costs in the older persons. Further research is needed to determine adequate intakes and innovative uses, including appropriate thresholds for improved health outcomes for this population.

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“…2023; 3(2):60-64 gility fractures in PMW affected by secondary hyperparathyroidism [11] . It has been reported that institutionalized individuals show a high prevalence of vitamin D deficiency and secondary hyperparathyroidism, leading to significantly increased hip fracture risk (more than 7 times) in this population [12] . In this context, serum 25(OH)D₃ and parathyroid hormone (PTH) measurement is a useful and cost-effective means of identifying patients at high risk of falls and fractures [13] .…”

Section: Calcifediol In Hip Fracturesmentioning

confidence: 95%

Calcifediol in patients with hip fractures

Moretti,

Tomaino,

Serlenga

et al. 2023

International Journal of Bone Fragility

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Vitamin D deficiency has a high prevalence in the elderly population. This condition can cause sarcopenia and osteoporomalacia, which are associated with an increased risk of falls and fractures, especially of the proximal femur. These fractures have devastating consequences in terms of mortality, disability, and healthcare and social costs. Considering that 60% of hip fracture patients have hypovitaminosis D, and a serum 25(OH)D₃ increase of 10 ng/ml reduces the risk of hip fracture by 20%, correction of vitamin D status is clearly essential. Among the available preparations of vitamin D, calcifediol is preferred in cases with liver disease, malabsorption, obesity, and concomitant use of corticosteroids. Calcifediol administration corrects vitamin D deficiency and suppresses parathyroid hormone within 1 week, reaching the serum 25(OH)D₃ threshold of 30 ng/ml in 2 weeks. Correction of hypovitaminosis D with calcifediol also improves muscle strength and physical performance, reducing the risk of falls. Evidence about the role of calcifediol in the management of hip fracture patients is still scarce. Compared with placebo, administration of calcifediol in combination with strengthening exercise led to increased overall survival in patients with hip fracture. The efficacy of calcifediol in rapidly normalizing vitamin D status might be particularly useful in patients at imminent risk of fracture, such as those with hip fracture who need to receive immediate treatment with anti-osteoporotic drugs. KEY WORDS: Hip fractures, vitamin D deficiency, calcifediol, osteoporosis.

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Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly

Cited by 14 publications

References 31 publications

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Calcifediol in patients with hip fractures

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