Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans

Holstein, Joerg H.; Herrmann, Markus; Splett, Christina; Herrmann, Wolfgang; Garcia, Patric; Histing, Tina; Graeber, Stefan; Ong, Mei Fang; Kurz, Karsten; Siebel, Thomas; Menger, Michael D.; Pohlemann, Tim

doi:10.3945/ajcn.2009.28116

Cited by 41 publications

(30 citation statements)

References 29 publications

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“…Evidence to support an effect of folate on bone While folate has been linked to BMD and a reduced fracture risk (54,70) , there is limited evidence to support a direct mechanistic effect of folate on bone, although one study reported a reduced trabecular thickness of bone in individuals with low folate status v. those with higher status (71) . Folate could have an indirect role on bone remodelling cells via its metabolic link (as a methyl source) to the methylation of DNA, proteins and other molecules and there is evidence, albeit somewhat inconsistent, to support a reduced methylation capacity as a pathomechanism responsible for poor bone health (57,(72)(73)(74) .…”

Section: Evidence To Support An Effect Of Homocysteine On Bonementioning

confidence: 99%

B-vitamins and bone in health and disease: the current evidence

et al. 2014

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Osteoporosis, a metabolic skeletal disease characterised by decreased bone mass and increased fracture risk, is a growing public health problem. Among the various risk factors for osteoporosis, calcium and vitamin D have well-established protective roles, but it is likely that other nutritional factors are also implicated. This review will explore the emerging evidence supporting a role for certain B-vitamins, homocysteine and the 677C→T polymorphism in the gene encoding the folate-metabolising enzyme methylenetetrahydrofolate reductase, in bone health and disease. The evidence, however, is not entirely consistent and as yet no clear mechanism has been defined to explain the potential link between B-vitamins and bone health. Coeliac disease, a common condition of malabsorption, induced by gluten ingestion in genetically susceptible individuals, is associated with an increased risk both of osteoporosis and inadequate B-vitamin status. Given the growing body of evidence linking low bone mineral density and/or increased fracture risk with low B-vitamin status and elevated homocysteine, optimal B-vitamin status may play an important protective role against osteoporosis in coeliac disease; to date, no trial has addressed this possible link.

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Section: Evidence To Support An Effect Of Homocysteine On Bonementioning

confidence: 99%

B-vitamins and bone in health and disease: the current evidence

et al. 2014

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“…Laboratory analysis was performed the morning after injury in a fasting state. Eleven bone specific parameters reflecting bone metabolism were examined: intact PTH [ 10 ], 25-hydroxy vitamin D3 (25-OH-D3) [ 11 ], beta-crosslaps (ß-CTX), pyridinoline in urine, desoxypyridinoline in urine (DPD) [ 10 , 12 ], procollagen type 1 N propeptide (PINP) [ 10 ], creatinine in urine [ 13 ], estradiol [ 10 ], homocysteine, vitamin B12 and folate [ 14 , 15 ]. Every pathologic aberration from the standard value was assessed with one point.…”

Section: Methodsmentioning

confidence: 99%

Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)

Kolios

Takur

Moghaddam

et al. 2011

BMC Musculoskelet Disord

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BackgroundOsteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD.MethodsIn our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures.Results76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly.ConclusionsAnamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.

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“…Holstein et al 14 concluded that only markers of bone formation (osteocalcin) were increased in individuals who had higher serum levels of B-complex vitamins, including B12. However, in the same study, no significant differences were found in the trabecular thickness of individuals with high and low serum levels of vitamin B12, thus questioning the true role of vitamin B12 in the turnover of bone biomarkers.…”

Section: Interventions With %Cho <20% and >40%mentioning

confidence: 99%

Vitamin B12, bone mineral density and fracture risk in adults: A systematic review

Macêdo

Carvalho

Cavalcanti

et al. 2017

Rev. Assoc. Med. Bras.

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Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans

Abstract: The results of the present study indicate that low serum folate and vitamin B-6 concentrations, but not low serum vitamin B-12 concentrations, are associated with an altered morphology of human bone.

Cited by 41 publications

References 29 publications

B-vitamins and bone in health and disease: the current evidence

B-vitamins and bone in health and disease: the current evidence

Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)

Vitamin B12, bone mineral density and fracture risk in adults: A systematic review

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