Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants

Moreno‐Solís, Gloria; Fernández‐Gutiérrez, Fernando; Torres-Borrego, J.; Torcello-Gáspar, Ricardo; Moreno, José Luis Gómez-Chaparro; Navero, J.L. Pérez

doi:10.1007/s00431-014-2405-4

Cited by 18 publications

(21 citation statements)

References 48 publications

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“…Recent studies 8,9 found low serum 25-hydroxyvitamin D levels in children with bronchiolitis. Other researchers 10,19 have shown that cord blood levels of 25-hydroxyvitamin D have a strong inverse association with ARIs during the first 3 months of life and with ARIs due to RSV during the first year of life.…”

Section: Discussionmentioning

confidence: 98%

“…Also, serum vitamin D levels decrease in children with bronchiolitis, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis. 6,8,9 Belderbos et al 10 performed a prospective birth cohort study and reported that children who are vitamin D deficient at birth have a sixfold risk of developing RSV bronchiolitis in the first year of life. Previous data suggest that action to change the vitamin D status of mothers during pregnancy and/or vitamin D supplementation of infants could reduce the risk of RSV-associated bronchiolitis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study

Saad

AzizNafisa

Elhoufey

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study

Saad

AzizNafisa

Elhoufey

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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“…In particular, VD plays a prominent role in boosting innate immunity, regulating adaptive immunity, and strengthening airway mucosal responses. Previous epidemiological studies show consistent independent associations between lower circulating levels of 25‐hydroxyvitamin D (25(OH)D) during childhood and an increased risk of upper and lower RTIs, including tuberculosis, pneumonia, asthma exacerbations, and bronchiolitis . Moreover, data from a recent individual‐patient‐data meta‐analysis of clinical studies show that VD supplementation protects against acute respiratory infections .…”

Section: Introductionmentioning

confidence: 88%

“…Previous epidemiological studies show consistent independent associations between lower circulating levels of 25-hydroxyvitamin D (25(OH)D) during childhood and an increased risk of upper and lower RTIs, 8 including tuberculosis, 9 pneumonia, 10 asthma exacerbations, 11 and bronchiolitis. 12,13 Moreover, data from a recent individual-patient-data meta-analysis of clinical studies show that VD supplementation protects against acute respiratory infections. 14 Variations in regional solar radiation (SR), a proxy of a population's VD status, have been associated with seasonal and latitudinal changes in the incidence and severity of respiratory infections such as influenza and tuberculosis, 15,16 but the associations of SR with infant bronchiolitis incidence and severity have not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Solar radiation, air pollution, and bronchiolitis hospitalizations in Chile: An ecological study

Terrazas

Castro-Rodriguez

Camargo

et al. 2019

Pediatric Pulmonology

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Objective To evaluate trends and geographic distribution of infant bronchiolitis hospitalizations in Chile, a country with large variation in solar radiation (SR) and high rates of urban air pollution. Methods We performed a nationwide ecological study of bronchiolitis hospitalizations from 2001 to 2014. We investigated the associations of regional SR (a proxy of vitamin D status) and regional fine particulate matter (PM2.5) air pollution with bronchiolitis hospitalizations. We also evaluated the role of sociodemographic factors, including regional poverty, education, indigenous population, and rurality rates. Results During the study period, 119 479 infants were hospitalized for bronchiolitis in Chile; 59% were boys. The mean bronchiolitis hospitalization rate increased from 29 to 41 per 1000 infants per year (P = .02). There was an inverse correlation between regional SR and incidence of hospital admissions for bronchiolitis (r = −0.52, P = .049), accounting for 27% of these hospitalizations. There was also a significant direct correlation between regional ambient PM2.5 and bronchiolitis hospitalizations (R = 0.68, P = .006), accounting for 42% of the variation in admission rate. High firewood and/or coal residential use for heating, high regional poverty, lower years of education, and high rurality rates were also significantly correlated with bronchiolitis hospitalization rates. None of the environmental or sociodemographic factors evaluated were correlated with regional case fatality rates or length of stay at the hospital. Conclusions This ecological study revealed significant associations between regional SR, air pollution, and sociodemographic factors with infant bronchiolitis hospitalizations in Chile, suggesting that these factors play a major role in the incidence and severity of respiratory infections in early childhood.

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“…Son yıllarda yapılan çalışmalarda RSV'ye bağlı gelişen akut bronşiyolitte, immünitenin gelişiminde de rolü olan D vitamini eksikliğinin önemli olduğu bildirilmiştir (11,14). Literatürde çocuklardaki ASYE ile D vitamini arasındaki ilişkiyi araştıran çeşitli çalışmalar bulunmaktadır (11,(15)(16)(17). Ancak ülkemizde bu konudaki çalışmalar az sayıdadır (15,16).…”

Section: Discussionunclassified

Akut Bronşiyolit Enfeksiyonu Olan Çocuklarda Viral Etkenler ile D Vitamin Düzeyinin Karşılaştırılması

Yalaki¹,

Taşar²,

Öney³

et al. 2019

J Pediatr Inf

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Akut bronşiyolite neden olan viral etkenler ile D vitamini düzeyi ve prognostik ilişkinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmada Ankara Eğitim ve Araştırma Hastanesi Çocuk Servisi ve Yoğun Bakımında akut bronşiyolit tanısı ile yatırılan hastaların dosyaları geriye dönük olarak incelendi. Hastalar klinik değerlendirilmesine göre hafif-orta ve ağır olarak sınıflandırıldı. Serum 25 (OH) D vitamin düzeyi < 20 ng/mL olan değerler D vitamini eksikliği, 20-30 ng/ mL arasındaki değerler D vitamini yetersizliği > 30 ng/mL olan değerler ise normal olarak değerlendirildi. Bulgular: D vitamini düzeylerine bakılan 130 hastanın yaş ortancası 8 ay (1-108) ve %60.8'i erkek idi; hastaların %69.2'sinin Türkiye Cumhuriyeti vatandaşı, %30.8'inin mülteci olduğu saptandı. Hastaların %28.5'i hafif, %30'u orta, %415'i ağır şiddet skoruna sahipti. Hastaların %56.9'una yüksek akımlı oksijen tedavisi uygulandı ve %50.8'ine oseltamivir tedavisi verildi. Hastaların %26.9'u yoğun bakımda, %3.8'i mekanik ventilatörde izlendi. Nazofarengeal sürüntü örneklerinden %55.3'ünde respiratuar sinsityal virüs (RSV) saptandı. Hastaların %36.9'unda D vitamini yetersizliği, %33.8'inde D vitamini eksikliği saptandı. Erkeklerde, Türkiye Cumhuriyeti vatandaşı olanlarda ve profilaktik D vitamini kullanmış olan hastalarda 25 (OH) D vitamini düzeyi diğer gruba göre istatistiksel olarak daha yüksek saptandı (p< 0.05). RSV enfeksiyonu olanların 25 (OH) D vitamin düzeyi 21.9 ng/mL, diğer viral sürüntü örneklerinde ise 24.2 ng/ mL olarak saptandı (p= 0.058). Yüksek akımlı oksijen tedavisi uygulanan hastaların %70.3'ünde ve oseltamivir tedavisi alan hastaların %71.2'sinde D vitamin düzeyleri normalin altında idi.

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Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants

Abstract: The prevalence of hypovitaminosis D is high in Spanish infants with bronchiolitis. The severity of acute bronchiolitis increases with a decline in serum 25 (OH) D level.

Cited by 18 publications

References 48 publications

Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study

Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study

Solar radiation, air pollution, and bronchiolitis hospitalizations in Chile: An ecological study

Akut Bronşiyolit Enfeksiyonu Olan Çocuklarda Viral Etkenler ile D Vitamin Düzeyinin Karşılaştırılması

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